G12 - GPR139 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM7 Y 285 7x53 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 130 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 134 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 134 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL1 L 54 12x48 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 133 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM2 Y 63 2x40 G.H5 M 379 G.H5.24
Van-der-waals TM2 Y 63 2x40 G.H5 M 379 G.H5.24
Polar TM3 R 126 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term I 335 - G.H2 F 239 G.H2.08
Van-der-waals C-term I 335 - G.H2 F 239 G.H2.08
Polar ICL2 H 137 34x54 G.H5 N 374 G.H5.19
Polar TM3 A 129 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 374 G.H5.19
Hydrophobic C-term Q 341 - G.H2 R 232 G.H2.01
Van-der-waals C-term Q 341 - G.H2 R 232 G.H2.01
Hydrophobic C-term F 319 - G.S1 K 59 G.S1.03
Hydrophobic C-term L 338 - G.H3 T 279 G.H3.11
Hydrophobic C-term F 319 - G.h2s4 I 245 G.h2s4.04
Van-der-waals C-term F 319 - G.h2s4 I 245 G.h2s4.04
Hydrophobic ICL2 L 134 34x51 G.H5 K 367 G.H5.12
Hydrophobic C-term F 319 - G.h2s4 G 244 G.h2s4.03
Van-der-waals C-term F 319 - G.h2s4 G 244 G.h2s4.03
Polar H8 K 290 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 290 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM2 Y 63 2x40 G.H5 D 377 G.H5.22
Van-der-waals TM2 Y 63 2x40 G.H5 D 377 G.H5.22
Hydrophobic C-term L 338 - G.h2s4 F 242 G.h2s4.01
Hydrophobic TM6 L 230 6x37 G.H5 L 380 G.H5.25
Hydrophobic C-term L 338 - G.H2 W 238 G.H2.07
Van-der-waals C-term L 338 - G.H2 W 238 G.H2.07
Hydrophobic ICL3 L 218 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 L 218 - G.h4s6 P 345 G.h4s6.20
Hydrophobic H8 S 289 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 289 8x47 G.H5 M 379 G.H5.24
Polar C-term M 337 - G.H3 T 279 G.H3.11
Hydrophobic C-term M 337 - G.H3 T 279 G.H3.11
Van-der-waals C-term M 337 - G.H3 T 279 G.H3.11
Polar ICL3 R 219 - G.H5 T 369 G.H5.14
Polar TM2 S 62 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 62 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 62 2x39 G.H5 D 377 G.H5.22
Hydrophobic C-term V 339 - G.H2 Q 236 G.H2.05
Van-der-waals C-term V 339 - G.H2 Q 236 G.H2.05
Ionic ICL3 R 219 - G.H5 D 368 G.H5.13
Polar ICL3 R 219 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 219 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 219 - G.H5 D 368 G.H5.13
Hydrophobic C-term I 321 - G.hns1 V 54 G.hns1.01
Hydrophobic TM6 T 226 6x33 G.H5 L 375 G.H5.20
Polar H8 S 289 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 289 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 289 8x47 G.H5 Q 381 G.H5.26
Polar C-term Q 341 - G.H3 E 272 G.H3.04
Hydrophobic C-term C 334 - G.H3 L 285 G.H3.17
Van-der-waals C-term C 334 - G.H3 L 285 G.H3.17
Hydrophobic TM3 R 126 3x50 G.H5 L 380 G.H5.25
Polar ICL2 P 133 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 133 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM2 S 62 2x39 G.H5 I 378 G.H5.23
Polar TM6 S 222 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 134 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 134 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 L 210 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term V 339 - G.H2 R 235 G.H2.04
Polar C-term C 334 - G.H3 N 283 G.H3.15
Hydrophobic C-term C 334 - G.H3 N 283 G.H3.15
Van-der-waals C-term C 334 - G.H3 N 283 G.H3.15
Hydrophobic TM6 K 225 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 225 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM3 A 129 3x53 G.H5 I 378 G.H5.23
Hydrophobic C-term F 319 - G.hns1 V 54 G.hns1.01
Van-der-waals C-term F 319 - G.hns1 V 54 G.hns1.01
Hydrophobic TM3 V 130 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 130 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 H 137 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 G 220 6x27 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 G 220 6x27 G.h4s6 P 345 G.h4s6.20
Hydrophobic H8 F 292 8x50 G.H5 M 379 G.H5.24
Hydrophobic TM5 K 213 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 213 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 Y 221 6x28 G.h4s6 K 344 G.h4s6.19
Hydrophobic C-term F 319 - G.h2s4 T 246 G.h2s4.05
Aromatic ICL3 R 219 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 R 219 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 R 219 - G.S6 F 347 G.S6.02
Hydrophobic TM6 I 229 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 I 229 6x36 G.H5 L 380 G.H5.25
Hydrophobic C-term L 338 - G.H3 I 276 G.H3.08
Van-der-waals TM4 P 142 4x39 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 133 34x50 G.H5 K 367 G.H5.12
Polar ICL3 F 216 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 F 216 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 F 216 - G.H5 D 368 G.H5.13
Polar C-term H 317 - G.H3 L 285 G.H3.17
Hydrophobic C-term H 317 - G.H3 L 285 G.H3.17
Polar ICL1 Q 59 12x53 G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 Q 59 12x53 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 Q 59 12x53 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 F 216 - G.H5 L 375 G.H5.20
Polar TM6 T 226 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 226 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 226 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 Y 221 6x28 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 221 6x28 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 Y 136 34x53 G.H5 I 378 G.H5.23
Hydrophobic ICL3 F 216 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 F 216 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 R 219 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 R 219 - G.h4s6 P 345 G.h4s6.20
Polar ICL3 R 219 - G.H5 A 365 G.H5.10
Hydrophobic ICL3 R 219 - G.H5 A 365 G.H5.10
Van-der-waals ICL3 R 219 - G.H5 A 365 G.H5.10
Hydrophobic ICL2 L 134 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 134 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM2 L 66 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 66 2x43 G.H5 M 379 G.H5.24
Hydrophobic C-term L 338 - G.H3 I 280 G.H3.12
Hydrophobic ICL2 H 137 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 137 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 130 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 130 3x54 G.H5 L 371 G.H5.16
Ionic TM2 K 60 2x37 G.H5 D 377 G.H5.22
Polar TM2 K 60 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 Y 136 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 133 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 210 5x65 G.H5 L 371 G.H5.16
Polar TM4 Y 141 4x38 G.HN R 52 G.HN.52
Aromatic TM4 Y 141 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 Y 141 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 Y 141 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL3 F 216 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 F 216 - G.H5 L 371 G.H5.16
Ionic H8 R 291 8x49 G.H5 D 377 G.H5.22
Polar H8 R 291 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 R 291 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 R 291 8x49 G.H5 D 377 G.H5.22
Polar ICL2 T 138 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 138 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 138 34x55 G.hns1 R 56 G.hns1.03