Gi2 - GPR139 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL3 R 219 - G.H5 D 342 G.H5.13
Polar ICL3 R 219 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 219 - G.H5 D 342 G.H5.13
Hydrophobic H8 S 289 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 226 6x33 G.H5 L 349 G.H5.20
Van-der-waals C-term M 337 - G.h1ha Y 61 G.h1ha.04
Polar ICL2 Y 136 34x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 Y 136 34x53 G.H5 C 352 G.H5.23
Polar TM3 A 129 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 348 G.H5.19
Ionic TM2 K 60 2x37 G.H5 D 351 G.H5.22
Polar TM2 K 60 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 S 62 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM6 Y 221 6x28 G.H5 L 349 G.H5.20
Polar TM4 A 143 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 A 143 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 A 143 4x40 G.HN E 28 G.HN.52
Aromatic TM4 Y 141 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 129 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 A 129 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM4 R 146 4x43 G.HN R 24 G.HN.48
Van-der-waals TM4 R 146 4x43 G.HN R 24 G.HN.48
Hydrophobic C-term M 337 - G.H1 K 51 G.H1.06
Hydrophobic ICL2 P 133 34x50 G.H5 I 344 G.H5.15
Aromatic TM6 Y 221 6x28 G.H5 F 355 G.H5.26
Hydrophobic TM6 Y 221 6x28 G.H5 F 355 G.H5.26
Van-der-waals TM6 Y 221 6x28 G.H5 F 355 G.H5.26
Hydrophobic ICL2 L 134 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 134 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM3 R 126 3x50 G.H5 L 354 G.H5.25
Hydrophobic C-term M 337 - G.H1 V 50 G.H1.05
Polar TM6 K 225 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 225 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 225 6x32 G.H5 F 355 G.H5.26
Hydrophobic ICL2 L 134 34x51 G.H5 F 337 G.H5.08
Polar ICL2 P 133 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 134 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 134 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM4 A 143 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 A 143 4x40 G.HN R 24 G.HN.48
Hydrophobic ICL3 F 216 - G.H5 D 342 G.H5.13
Hydrophobic TM5 K 213 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 K 213 5x68 G.H5 I 345 G.H5.16
Polar ICL2 H 137 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 137 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 137 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 134 34x51 G.H5 T 341 G.H5.12
Ionic TM5 K 213 5x68 G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 219 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 219 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 F 216 - G.H5 I 345 G.H5.16
Hydrophobic C-term V 339 - G.hfs2 V 180 G.hfs2.03
Ionic H8 R 291 8x49 G.H5 D 351 G.H5.22
Polar H8 R 291 8x49 G.H5 D 351 G.H5.22
Van-der-waals H8 R 291 8x49 G.H5 D 351 G.H5.22
Hydrophobic C-term I 335 - G.H1 K 54 G.H1.09
Hydrophobic ICL2 P 133 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 133 34x50 G.H5 I 345 G.H5.16
Polar ICL2 H 137 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 137 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 210 5x65 G.H5 I 345 G.H5.16
Polar ICL3 R 219 - G.H5 D 338 G.H5.09
Hydrophobic ICL2 L 134 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 L 134 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 Y 136 34x53 G.H5 N 348 G.H5.19
Ionic ICL2 K 135 34x52 G.s2s3 D 194 G.s2s3.02
Polar ICL2 K 135 34x52 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 K 135 34x52 G.s2s3 D 194 G.s2s3.02
Van-der-waals TM5 K 213 5x68 G.H5 T 341 G.H5.12
Polar C-term Q 341 - G.hfs2 T 183 G.hfs2.06
Polar ICL2 H 137 34x54 G.H5 N 348 G.H5.19
Hydrophobic TM6 I 229 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 229 6x36 G.H5 L 354 G.H5.25
Polar TM2 S 62 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 S 62 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 S 62 2x39 G.H5 D 351 G.H5.22
Polar TM6 T 226 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 226 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 226 6x33 G.H5 L 354 G.H5.25
Hydrophobic C-term I 321 - G.H2 H 214 G.H2.09
Van-der-waals C-term I 321 - G.H2 H 214 G.H2.09
Polar TM3 R 126 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL3 F 216 - G.H5 L 349 G.H5.20
Polar TM6 Y 221 6x28 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 Y 221 6x28 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Y 221 6x28 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 219 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 219 - G.S6 Y 321 G.S6.02
Polar C-term Y 340 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term Y 340 - G.hfs2 T 183 G.hfs2.06
Hydrophobic TM6 L 230 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL3 R 219 - G.H5 A 339 G.H5.10
Van-der-waals ICL3 R 219 - G.H5 A 339 G.H5.10
Polar ICL3 R 219 - G.S6 H 323 G.S6.04
Hydrophobic ICL3 R 219 - G.S6 H 323 G.S6.04
Van-der-waals ICL3 R 219 - G.S6 H 323 G.S6.04
Hydrophobic C-term I 335 - G.h1ha E 58 G.h1ha.01
Van-der-waals C-term I 335 - G.h1ha E 58 G.h1ha.01
Hydrophobic ICL2 P 133 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM3 V 130 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 130 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM4 Y 141 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 Y 141 4x38 G.HN E 28 G.HN.52
Polar TM6 Y 221 6x28 G.H5 L 354 G.H5.25
Polar ICL2 T 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 138 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 F 216 - G.H5 K 346 G.H5.17
Hydrophobic TM6 Y 221 6x28 G.H5 K 346 G.H5.17
Hydrophobic C-term I 335 - G.S2 T 188 G.S2.04
Polar TM4 P 142 4x39 G.HN R 24 G.HN.48
Polar TM6 G 220 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 G 220 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 G 220 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 L 210 5x65 G.H5 L 349 G.H5.20