G14 - GPR141 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 M 45 12x48 G.H5 V 355 G.H5.26
Polar TM6 Q 219 6x29 G.H5 L 345 G.H5.16
Hydrophobic TM6 Q 219 6x29 G.H5 L 345 G.H5.16
Van-der-waals TM6 Q 219 6x29 G.H5 L 345 G.H5.16
Polar TM7 G 286 7x56 G.H5 N 353 G.H5.24
Hydrophobic TM7 G 286 7x56 G.H5 N 353 G.H5.24
Van-der-waals TM7 G 286 7x56 G.H5 N 353 G.H5.24
Hydrophobic TM1 L 41 1x57 G.H5 L 354 G.H5.25
Van-der-waals TM1 L 41 1x57 G.H5 L 354 G.H5.25
Hydrophobic ICL2 D 122 34x52 G.H5 F 352 G.H5.23
Van-der-waals ICL2 D 122 34x52 G.H5 F 352 G.H5.23
Polar H8 H 289 8x48 G.H5 Q 346 G.H5.17
Hydrophobic H8 H 289 8x48 G.H5 Q 346 G.H5.17
Van-der-waals H8 H 289 8x48 G.H5 Q 346 G.H5.17
Polar TM3 R 113 3x50 G.H5 V 355 G.H5.26
Hydrophobic TM3 R 113 3x50 G.H5 V 355 G.H5.26
Van-der-waals TM3 R 113 3x50 G.H5 V 355 G.H5.26
Polar TM3 R 113 3x50 G.H5 F 352 G.H5.23
Polar ICL2 C 120 34x50 G.hns1 A 32 G.hns1.01
Hydrophobic ICL2 C 120 34x50 G.hns1 A 32 G.hns1.01
Van-der-waals ICL2 C 120 34x50 G.hns1 A 32 G.hns1.01
Polar TM5 K 210 5x64 G.s2s3 N 194 G.s2s3.02
Van-der-waals TM5 K 210 5x64 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM6 W 222 6x32 G.H5 L 349 G.H5.20
Van-der-waals TM6 W 222 6x32 G.H5 L 349 G.H5.20
Hydrophobic H8 K 292 8x51 G.H5 L 349 G.H5.20
Van-der-waals H8 K 292 8x51 G.H5 L 349 G.H5.20
Polar ICL3 H 218 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL3 H 218 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL3 H 218 - G.s2s3 N 194 G.s2s3.02
Ionic ICL2 K 123 34x53 G.H5 E 351 G.H5.22
Polar ICL2 K 123 34x53 G.H5 E 351 G.H5.22
Van-der-waals ICL2 K 123 34x53 G.H5 E 351 G.H5.22
Van-der-waals TM6 E 220 6x30 G.hns1 A 32 G.hns1.01
Hydrophobic TM7 F 283 7x53 G.H5 L 354 G.H5.25
Van-der-waals TM7 F 283 7x53 G.H5 L 354 G.H5.25
Polar ICL2 D 122 34x52 G.S1 E 35 G.S1.01
Polar TM6 Q 219 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM6 Q 219 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 Q 219 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM5 K 210 5x64 G.hns1 R 33 G.hns1.02
Van-der-waals TM5 K 210 5x64 G.hns1 R 33 G.hns1.02
Polar ICL3 S 217 - G.s2s3 E 193 G.s2s3.01
Hydrophobic ICL3 S 217 - G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL3 S 217 - G.s2s3 E 193 G.s2s3.01
Polar ICL2 C 120 34x50 G.HN K 30 G.HN.52
Hydrophobic ICL2 C 120 34x50 G.HN K 30 G.HN.52
Van-der-waals ICL2 C 120 34x50 G.HN K 30 G.HN.52
Polar TM6 E 220 6x30 G.hns1 R 34 G.hns1.03
Hydrophobic TM6 E 220 6x30 G.hns1 R 34 G.hns1.03
Van-der-waals TM6 E 220 6x30 G.hns1 R 34 G.hns1.03
Hydrophobic TM6 E 220 6x30 G.hns1 R 33 G.hns1.02
Van-der-waals TM6 E 220 6x30 G.hns1 R 33 G.hns1.02
Hydrophobic TM3 F 117 3x54 G.hns1 A 32 G.hns1.01
Van-der-waals TM3 F 117 3x54 G.hns1 A 32 G.hns1.01
Hydrophobic TM6 Q 219 6x29 G.S3 I 195 G.S3.01
Van-der-waals TM6 Q 219 6x29 G.S3 I 195 G.S3.01
Hydrophobic TM2 T 51 2x39 G.H5 V 355 G.H5.26
Van-der-waals TM2 T 51 2x39 G.H5 V 355 G.H5.26
Polar TM6 A 223 6x33 G.H5 N 353 G.H5.24
Hydrophobic TM3 I 109 3x46 G.H5 V 355 G.H5.26
Van-der-waals TM3 I 109 3x46 G.H5 V 355 G.H5.26
Polar ICL2 C 120 34x50 G.HN D 31 G.HN.53
Hydrophobic ICL2 C 120 34x50 G.HN D 31 G.HN.53
Van-der-waals ICL2 C 120 34x50 G.HN D 31 G.HN.53
Hydrophobic H8 K 292 8x51 G.H5 N 353 G.H5.24
Van-der-waals H8 K 292 8x51 G.H5 N 353 G.H5.24
Polar ICL4 G 287 - G.H5 R 350 G.H5.21
Hydrophobic ICL4 G 287 - G.H5 R 350 G.H5.21
Van-der-waals ICL4 G 287 - G.H5 R 350 G.H5.21
Hydrophobic TM7 F 283 7x53 G.H5 V 355 G.H5.26
Van-der-waals TM7 F 283 7x53 G.H5 V 355 G.H5.26
Hydrophobic TM6 A 223 6x33 G.hns1 R 34 G.hns1.03
Van-der-waals TM6 A 223 6x33 G.hns1 R 34 G.hns1.03
Hydrophobic TM1 I 38 1x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 223 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 C 120 34x50 G.HN K 29 G.HN.51
Van-der-waals ICL2 C 120 34x50 G.HN K 29 G.HN.51
Hydrophobic TM2 T 52 2x40 G.H5 V 355 G.H5.26
Polar TM6 K 226 6x36 G.H5 N 353 G.H5.24
Hydrophobic TM6 K 226 6x36 G.H5 N 353 G.H5.24
Van-der-waals TM6 K 226 6x36 G.H5 N 353 G.H5.24
Hydrophobic TM3 I 116 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM5 L 211 5x65 G.s2s3 N 194 G.s2s3.02
Van-der-waals TM5 L 211 5x65 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL4 G 287 - G.H5 N 353 G.H5.24
Polar ICL3 H 218 - G.s2s3 E 193 G.s2s3.01
Hydrophobic ICL3 H 218 - G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL3 H 218 - G.s2s3 E 193 G.s2s3.01
Hydrophobic TM2 V 55 2x43 G.H5 V 355 G.H5.26
Hydrophobic ICL1 M 45 12x48 G.H5 L 354 G.H5.25
Van-der-waals ICL1 M 45 12x48 G.H5 L 354 G.H5.25