GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 73.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Polar | N-term | K | 11 | - | G.hfs2 | T | 178 | G.hfs2.06 |
Polar | N-term | W | 66 | - | H.HA | R | 82 | H.HA.24 |
Hydrophobic | TM4 | S | 271 | 4x39 | G.HN | K | 20 | G.HN.48 |
Polar | TM6 | K | 354 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | K | 354 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | K | 354 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | S | 418 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | N-term | W | 66 | - | G.s4h3 | V | 231 | G.s4h3.09 |
Hydrophobic | N-term | L | 19 | - | G.H2 | K | 206 | G.H2.06 |
Van-der-waals | N-term | L | 19 | - | G.H2 | K | 206 | G.H2.06 |
Hydrophobic | TM5 | L | 340 | 5x65 | G.H5 | L | 344 | G.H5.20 |
Polar | TM6 | R | 351 | 6x29 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | TM6 | R | 351 | 6x29 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | N-term | Y | 31 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Van-der-waals | N-term | Y | 31 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Polar | TM6 | S | 355 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | S | 355 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | S | 355 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Polar | ICL2 | R | 267 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Polar | ICL3 | R | 343 | - | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | ICL3 | R | 343 | - | G.H5 | T | 336 | G.H5.12 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | N-term | I | 70 | - | H.HA | T | 85 | H.HA.27 |
Van-der-waals | N-term | I | 70 | - | H.HA | T | 85 | H.HA.27 |
Hydrophobic | TM6 | S | 355 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | N-term | E | 9 | - | G.S2 | I | 181 | G.S2.02 |
Van-der-waals | N-term | E | 9 | - | G.S2 | I | 181 | G.S2.02 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | N-term | I | 70 | - | H.HA | A | 83 | H.HA.25 |
Van-der-waals | N-term | T | 23 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | N-term | I | 22 | - | G.H2 | W | 207 | G.H2.07 |
Van-der-waals | N-term | I | 22 | - | G.H2 | W | 207 | G.H2.07 |
Ionic | TM2 | R | 190 | 2x37 | G.H5 | E | 342 | G.H5.18 |
Polar | TM2 | R | 190 | 2x37 | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | TM2 | R | 190 | 2x37 | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | TM6 | R | 351 | 6x29 | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | TM6 | I | 358 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | I | 358 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Hydrophobic | N-term | L | 68 | - | H.HA | A | 83 | H.HA.25 |
Van-der-waals | N-term | L | 68 | - | H.HA | A | 83 | H.HA.25 |
Hydrophobic | N-term | L | 19 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | N-term | L | 19 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | N-term | I | 22 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | N-term | I | 22 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | N-term | R | 69 | - | H.HA | T | 86 | H.HA.28 |
Ionic | TM2 | R | 190 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Polar | TM2 | R | 190 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | R | 190 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM3 | R | 256 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Polar | N-term | R | 71 | - | G.s4h3 | D | 234 | G.s4h3.12 |
Van-der-waals | N-term | R | 71 | - | G.s4h3 | D | 234 | G.s4h3.12 |
Polar | N-term | L | 26 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | N-term | L | 26 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | N-term | L | 26 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | N-term | L | 26 | - | G.H3 | I | 249 | G.H3.12 |
Van-der-waals | N-term | L | 26 | - | G.H3 | I | 249 | G.H3.12 |
Hydrophobic | N-term | L | 26 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | N-term | L | 26 | - | G.H3 | H | 252 | G.H3.15 |
Polar | TM2 | S | 192 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | S | 192 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | S | 192 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | N-term | V | 25 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | N-term | V | 25 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | N-term | L | 19 | - | G.H2 | H | 209 | G.H2.09 |
Van-der-waals | N-term | L | 19 | - | G.H2 | H | 209 | G.H2.09 |
Hydrophobic | TM6 | R | 351 | 6x29 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | R | 351 | 6x29 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | N-term | W | 14 | - | G.S2 | I | 180 | G.S2.01 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | N-term | L | 19 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | N-term | L | 68 | - | H.HA | R | 82 | H.HA.24 |
Van-der-waals | N-term | L | 68 | - | H.HA | R | 82 | H.HA.24 |
Polar | N-term | W | 14 | - | G.H2 | H | 209 | G.H2.09 |
Aromatic | N-term | W | 14 | - | G.H2 | H | 209 | G.H2.09 |
Hydrophobic | N-term | W | 14 | - | G.H2 | H | 209 | G.H2.09 |
Van-der-waals | N-term | W | 14 | - | G.H2 | H | 209 | G.H2.09 |
Polar | N-term | V | 15 | - | G.H2 | H | 209 | G.H2.09 |
Hydrophobic | ICL3 | R | 343 | - | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM6 | L | 348 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | N-term | V | 39 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM5 | L | 340 | 5x65 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM6 | L | 359 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | N-term | L | 68 | - | H.HA | T | 86 | H.HA.28 |
Van-der-waals | N-term | L | 68 | - | H.HA | T | 86 | H.HA.28 |
Hydrophobic | TM6 | R | 351 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | R | 351 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | N-term | L | 6 | - | H.HA | E | 61 | H.HA.03 |
Hydrophobic | N-term | W | 14 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | N-term | W | 14 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | N-term | I | 70 | - | H.HA | L | 87 | H.HA.29 |
Van-der-waals | N-term | I | 70 | - | H.HA | L | 87 | H.HA.29 |
Polar | TM3 | A | 259 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 259 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | A | 259 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | A | 268 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | A | 268 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Polar | TM3 | R | 256 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 256 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 256 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | N-term | L | 6 | - | H.HA | E | 64 | H.HA.06 |
Van-der-waals | N-term | L | 6 | - | H.HA | E | 64 | H.HA.06 |
Hydrophobic | N-term | I | 22 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Ionic | ICL3 | R | 343 | - | G.H5 | D | 337 | G.H5.13 |
Polar | ICL3 | R | 343 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | N-term | I | 22 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | N-term | I | 22 | - | G.H2 | R | 204 | G.H2.04 |
Ionic | N-term | R | 69 | - | G.s4h3 | D | 234 | G.s4h3.12 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | L | 260 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | N-term | I | 22 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | N-term | I | 70 | - | H.HA | T | 86 | H.HA.28 |
Van-der-waals | N-term | I | 70 | - | H.HA | T | 86 | H.HA.28 |