GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 73.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 260 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Ionic | N-term | E | 9 | - | G.H1 | K | 54 | G.H1.09 |
Polar | N-term | E | 9 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | N-term | E | 9 | - | G.H1 | K | 54 | G.H1.09 |
Polar | N-term | Q | 43 | - | G.hgh4 | E | 290 | G.hgh4.04 |
Hydrophobic | N-term | Q | 43 | - | G.hgh4 | E | 290 | G.hgh4.04 |
Van-der-waals | N-term | Q | 43 | - | G.hgh4 | E | 290 | G.hgh4.04 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | N-term | Y | 31 | - | G.s4h3 | T | 241 | G.s4h3.14 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.S2 | F | 192 | G.S2.08 |
Polar | TM6 | Q | 349 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | Q | 349 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 349 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | K | 354 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL3 | R | 343 | - | G.H5 | D | 338 | G.H5.09 |
Polar | ICL3 | R | 343 | - | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | D | 338 | G.H5.09 |
Polar | ICL2 | R | 267 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | L | 260 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM6 | S | 355 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | R | 267 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | N-term | L | 26 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | TM5 | L | 340 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Ionic | TM6 | R | 351 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | R | 351 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | N-term | W | 14 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | N-term | W | 14 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | N-term | W | 14 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | TM6 | I | 358 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | I | 358 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | N-term | W | 14 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | N-term | P | 7 | - | G.h1ha | S | 58 | G.h1ha.01 |
Hydrophobic | N-term | V | 25 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | N-term | V | 25 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | N-term | T | 23 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | TM6 | L | 359 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Polar | TM2 | Y | 193 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | Y | 193 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | ICL1 | T | 188 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL1 | T | 188 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | N-term | L | 26 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM3 | A | 259 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 259 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | S | 192 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | N-term | L | 19 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | N-term | L | 19 | - | G.H2 | K | 210 | G.H2.05 |
Polar | ICL2 | A | 268 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | A | 268 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | A | 268 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM6 | R | 351 | 6x29 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | TM6 | R | 351 | 6x29 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL2 | A | 268 | 34x55 | G.S3 | L | 195 | G.S3.01 |
Polar | N-term | K | 11 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Polar | N-term | V | 25 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | N-term | V | 25 | - | G.H3 | S | 253 | G.H3.11 |
Polar | N-term | V | 15 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | N-term | V | 15 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | N-term | V | 15 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM2 | R | 190 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Aromatic | TM2 | R | 190 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 190 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 190 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Polar | N-term | E | 9 | - | G.S2 | N | 188 | G.S2.04 |
Hydrophobic | N-term | E | 9 | - | G.S2 | N | 188 | G.S2.04 |
Van-der-waals | N-term | E | 9 | - | G.S2 | N | 188 | G.S2.04 |
Hydrophobic | TM5 | L | 340 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | N-term | W | 14 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | N-term | W | 14 | - | G.H2 | K | 210 | G.H2.05 |
Polar | ICL2 | R | 267 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | N-term | L | 19 | - | G.H2 | I | 213 | G.H2.08 |
Polar | N-term | Q | 10 | - | G.S2 | K | 189 | G.S2.05 |
Van-der-waals | N-term | Q | 10 | - | G.S2 | K | 189 | G.S2.05 |
Hydrophobic | TM3 | R | 256 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | A | 259 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 259 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 259 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | N-term | W | 14 | - | G.H2 | H | 214 | G.H2.09 |
Aromatic | N-term | W | 14 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | N-term | W | 14 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | N-term | W | 14 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | L | 348 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | N-term | K | 11 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | N-term | M | 4 | - | G.h1ha | G | 59 | G.h1ha.02 |
Hydrophobic | TM4 | S | 271 | 4x39 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | N-term | L | 26 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | N-term | L | 26 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Polar | N-term | Q | 10 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | N-term | Q | 10 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | N-term | I | 22 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | N-term | I | 22 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | N-term | M | 8 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | N-term | E | 9 | - | G.S2 | V | 186 | G.S2.02 |
Polar | N-term | Y | 31 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | N-term | Y | 31 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.S1 | I | 34 | G.S1.02 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.S1 | I | 34 | G.S1.02 |
Polar | TM6 | R | 351 | 6x29 | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | TM6 | R | 351 | 6x29 | G.h4s6 | T | 317 | G.h4s6.10 |
Polar | N-term | Y | 31 | - | G.H3 | R | 249 | G.H3.07 |
Aromatic | N-term | Y | 31 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | N-term | Y | 31 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | N-term | Y | 31 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | R | 256 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 256 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 256 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Ionic | ICL3 | R | 343 | - | G.H5 | D | 342 | G.H5.13 |
Polar | ICL3 | R | 343 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL3 | R | 343 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | K | 354 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 354 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 354 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Polar | N-term | T | 28 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | N-term | T | 28 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | N-term | K | 11 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | N-term | K | 11 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Ionic | ICL2 | H | 265 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | N-term | Y | 31 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | N-term | Y | 31 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | N-term | Y | 31 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM2 | S | 192 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 192 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | N-term | E | 9 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | N-term | E | 9 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Polar | TM6 | S | 355 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 355 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 355 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | R | 351 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | R | 351 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | R | 351 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Polar | N-term | I | 12 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | N-term | I | 12 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | N-term | I | 12 | - | G.S2 | I | 185 | G.S2.01 |
Polar | ICL3 | R | 343 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL3 | R | 343 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | N-term | L | 26 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | N-term | L | 26 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | N-term | I | 22 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | N-term | P | 7 | - | G.S2 | K | 189 | G.S2.05 |
Van-der-waals | N-term | P | 7 | - | G.S2 | K | 189 | G.S2.05 |
Ionic | N-term | D | 35 | - | G.H3 | R | 249 | G.H3.07 |
Polar | N-term | D | 35 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | N-term | D | 35 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | N-term | D | 35 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | N-term | I | 22 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | TM6 | R | 351 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL3 | R | 343 | - | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | A | 268 | 34x55 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | A | 268 | 34x55 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL1 | R | 189 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL1 | R | 189 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL1 | R | 189 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | N-term | P | 7 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | H8 | S | 418 | 8x47 | G.H5 | G | 353 | G.H5.24 |