S-arrestin - GPR143 complex model

GPCR CLASS (FAMILY)

Unclassified

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2024-10-31

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR143 65.3
S-arrestin 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 T 62 - s8s9 S 143 N.s8s9.07
Hydrophobic ICL1 T 62 - s8s9 S 143 N.s8s9.07
Van-der-waals ICL1 T 62 - s8s9 S 143 N.s8s9.07
Ionic TM6 E 235 6x26 S6 R 85 N.S6.03
Polar TM6 E 235 6x26 S6 R 85 N.S6.03
Hydrophobic TM6 E 235 6x26 S6 R 85 N.S6.03
Van-der-waals TM6 E 235 6x26 S6 R 85 N.S6.03
Polar ICL2 S 148 - s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 S 148 - s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 S 148 - s15s16 S 256 C.s15s16.05
Polar TM6 E 235 6x26 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 E 235 6x26 s15s16 Y 254 C.s15s16.03
Polar ICL1 S 63 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL1 S 63 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 S 63 - s8s9 Q 141 N.s8s9.05
Ionic TM6 R 237 6x28 s9s10 E 165 N.s9s10.07
Polar TM6 R 237 6x28 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 237 6x28 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 237 6x28 s9s10 E 165 N.s9s10.07
Polar ICL1 T 62 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 T 62 - s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 M 238 6x29 S6 F 83 N.S6.01
Van-der-waals TM6 M 238 6x29 S6 F 83 N.S6.01
Polar ICL2 R 147 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 R 147 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 R 147 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 S 148 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 S 148 - s15s16 S 255 C.s15s16.04
Polar ICL1 S 63 - s8s9 G 144 N.s8s9.08
Hydrophobic TM2 S 67 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 S 67 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 R 147 - s15s16 S 255 C.s15s16.04
Polar ICL2 S 148 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 145 3x54 s15s16 Y 254 C.s15s16.03
Polar ICL2 S 148 - S16 D 257 C.S16.01
Hydrophobic ICL2 S 148 - S16 D 257 C.S16.01
Van-der-waals ICL2 S 148 - S16 D 257 C.S16.01
Hydrophobic TM3 V 144 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 V 144 3x53 S6 F 83 N.S6.01
Hydrophobic TM2 P 65 2x37 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 P 65 2x37 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 L 151 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 L 151 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL3 Y 231 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 Y 231 - s15s16 Y 254 C.s15s16.03
Polar TM6 R 245 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 R 245 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 R 245 6x36 s5s6 V 78 N.s5s6.07
Polar TM6 R 245 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 R 245 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 R 245 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 V 144 3x53 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 V 144 3x53 s15s16 Y 254 C.s15s16.03
Polar TM6 N 234 6x25 S6 D 86 N.S6.04
Hydrophobic TM2 P 65 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 P 65 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 L 71 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 V 144 3x53 S5 Y 71 N.S5.12
Polar ICL1 S 63 - s8s9 P 140 N.s8s9.04
Van-der-waals ICL1 S 63 - s8s9 P 140 N.s8s9.04
Hydrophobic TM2 L 71 2x43 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 R 245 6x36 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 R 245 6x36 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 I 145 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 145 3x54 S6 F 83 N.S6.01
Hydrophobic C-term W 329 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term W 329 - s1s2 R 22 N.s1s2.02
Hydrophobic ICL2 G 150 - S16 D 257 C.S16.01
Hydrophobic TM6 M 238 6x29 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 M 238 6x29 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 Y 311 7x54 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 311 7x54 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 Y 137 3x46 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 Y 137 3x46 s5s6 I 79 N.s5s6.08
Polar ICL1 S 63 - s8s9 D 142 N.s8s9.06
Hydrophobic TM6 M 238 6x29 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 M 238 6x29 s5s6 L 81 N.s5s6.10
Polar ICL1 S 63 - s8s9 S 143 N.s8s9.07
Van-der-waals ICL1 S 63 - s8s9 S 143 N.s8s9.07
Hydrophobic TM6 M 238 6x29 S6 R 85 N.S6.03
Hydrophobic TM6 V 241 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 V 241 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM2 V 68 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 V 68 2x40 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 P 65 2x37 s8s9 G 144 N.s8s9.08
Hydrophobic TM6 I 242 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 I 242 6x33 s5s6 L 81 N.s5s6.10
Ionic TM6 R 245 6x36 s5s6 D 77 N.s5s6.06
Polar TM6 R 245 6x36 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 R 245 6x36 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 R 245 6x36 s5s6 D 77 N.s5s6.06
Polar ICL1 S 63 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 S 63 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 L 151 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 151 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 T 232 - S6 R 85 N.S6.03
Hydrophobic C-term I 327 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term I 327 - s1s2 R 22 N.s1s2.02
Hydrophobic ICL2 G 150 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 G 150 - s8s9 K 145 N.s8s9.09
Ionic TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 M 238 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 M 238 6x29 S6 R 84 N.S6.02