GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 22.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 368 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL1 | P | 65 | - | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | ICL1 | P | 65 | - | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | V | 355 | G.H5.26 |
Polar | C-term | H | 383 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | C-term | H | 383 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | TM6 | E | 235 | 6x22 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | E | 235 | 6x22 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | A | 385 | - | G.S2 | Y | 188 | G.S2.04 |
Van-der-waals | C-term | A | 385 | - | G.S2 | Y | 188 | G.S2.04 |
Polar | C-term | H | 383 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | H | 383 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | C-term | A | 367 | - | G.H3 | T | 253 | G.H3.11 |
Polar | TM3 | Y | 137 | 3x46 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | Y | 137 | 3x46 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | A | 385 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | A | 385 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | I | 242 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 144 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | G | 374 | - | G.H2 | I | 213 | G.H2.08 |
Polar | C-term | E | 387 | - | G.h1ha | S | 61 | G.h1ha.02 |
Hydrophobic | C-term | E | 387 | - | G.h1ha | S | 61 | G.h1ha.02 |
Van-der-waals | C-term | E | 387 | - | G.h1ha | S | 61 | G.h1ha.02 |
Polar | C-term | A | 336 | - | G.H4 | R | 299 | G.H4.05 |
Van-der-waals | C-term | A | 336 | - | G.H4 | R | 299 | G.H4.05 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.HN | D | 28 | G.HN.50 |
Van-der-waals | TM3 | R | 147 | 3x56 | G.HN | D | 28 | G.HN.50 |
Hydrophobic | C-term | H | 383 | - | G.S2 | I | 186 | G.S2.02 |
Van-der-waals | C-term | H | 383 | - | G.S2 | I | 186 | G.S2.02 |
Polar | C-term | S | 335 | - | G.H4 | R | 299 | G.H4.05 |
Van-der-waals | C-term | S | 335 | - | G.H4 | R | 299 | G.H4.05 |
Polar | C-term | S | 372 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | TM3 | S | 148 | 3x57 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | TM3 | S | 148 | 3x57 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | C-term | L | 371 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | N | 234 | 6x21 | G.H5 | Q | 346 | G.H5.17 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Polar | TM3 | I | 145 | 3x54 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | C-term | I | 382 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | I | 382 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.HN | K | 29 | G.HN.51 |
Van-der-waals | TM3 | R | 147 | 3x56 | G.HN | K | 29 | G.HN.51 |
Hydrophobic | C-term | L | 371 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | C-term | I | 382 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | T | 384 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | R | 350 | G.H5.21 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | R | 350 | G.H5.21 |
Polar | TM3 | R | 146 | 3x55 | G.HN | K | 29 | G.HN.51 |
Hydrophobic | TM3 | R | 146 | 3x55 | G.HN | K | 29 | G.HN.51 |
Van-der-waals | TM3 | R | 146 | 3x55 | G.HN | K | 29 | G.HN.51 |
Polar | TM6 | N | 234 | 6x21 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | N | 234 | 6x21 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | N | 234 | 6x21 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | L | 345 | G.H5.16 |
Polar | C-term | S | 378 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | I | 380 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | I | 380 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | TM6 | V | 241 | 6x28 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | V | 241 | 6x28 | G.H5 | V | 355 | G.H5.26 |
Polar | C-term | L | 371 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | L | 371 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | L | 371 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | ICL1 | T | 62 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | C-term | L | 371 | - | G.H3 | I | 254 | G.H3.12 |
Polar | TM6 | R | 245 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | R | 245 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | L | 368 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | L | 368 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | TM6 | R | 245 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | M | 370 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM3 | R | 147 | 3x56 | G.HN | L | 25 | G.HN.47 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.HN | L | 25 | G.HN.47 |
Van-der-waals | TM3 | R | 147 | 3x56 | G.HN | L | 25 | G.HN.47 |
Hydrophobic | C-term | L | 371 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | L | 371 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | TM3 | A | 141 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | A | 141 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | N | 353 | G.H5.24 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.hns1 | A | 32 | G.hns1.01 |
Van-der-waals | TM3 | R | 147 | 3x56 | G.hns1 | A | 32 | G.hns1.01 |
Hydrophobic | C-term | I | 380 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | Q | 346 | G.H5.17 |
Polar | TM3 | Y | 137 | 3x46 | G.H5 | N | 353 | G.H5.24 |
Polar | C-term | G | 374 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM2 | V | 68 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | V | 68 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Polar | TM6 | R | 245 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | R | 245 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | E | 235 | 6x22 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM6 | E | 235 | 6x22 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | ICL1 | P | 65 | - | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | ICL1 | P | 65 | - | G.H5 | F | 352 | G.H5.23 |
Polar | TM3 | S | 148 | 3x57 | G.hns1 | A | 32 | G.hns1.01 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.hns1 | A | 32 | G.hns1.01 |
Van-der-waals | TM3 | S | 148 | 3x57 | G.hns1 | A | 32 | G.hns1.01 |
Hydrophobic | C-term | A | 385 | - | G.S2 | I | 186 | G.S2.02 |
Hydrophobic | ICL3 | Y | 231 | - | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | ICL3 | Y | 231 | - | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | R | 146 | 3x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | C-term | L | 371 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | I | 380 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | I | 380 | - | G.H2 | H | 214 | G.H2.09 |
Polar | TM3 | S | 148 | 3x57 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM3 | S | 148 | 3x57 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | C-term | M | 370 | - | G.H2 | R | 210 | G.H2.05 |
Van-der-waals | C-term | M | 370 | - | G.H2 | R | 210 | G.H2.05 |