GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM2 | V | 68 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | V | 68 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | L | 371 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | L | 371 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | L | 371 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | G | 374 | - | G.H2 | R | 205 | G.H2.01 |
Van-der-waals | C-term | G | 374 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | L | 368 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL2 | G | 150 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 151 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL1 | P | 65 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL1 | P | 65 | - | G.H5 | C | 351 | G.H5.23 |
Ionic | C-term | D | 376 | - | G.H2 | K | 209 | G.H2.05 |
Polar | C-term | D | 376 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | D | 376 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | V | 144 | 3x53 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | L | 371 | - | G.H2 | K | 209 | G.H2.05 |
Polar | C-term | S | 372 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | S | 372 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | S | 372 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | A | 367 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | A | 367 | - | G.H2 | I | 212 | G.H2.08 |
Polar | C-term | A | 377 | - | G.H2 | S | 206 | G.H2.02 |
Hydrophobic | C-term | A | 377 | - | G.s4h3 | E | 236 | G.s4h3.10 |
Polar | TM6 | N | 234 | 6x21 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | N | 234 | 6x21 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | N | 234 | 6x21 | G.H5 | D | 341 | G.H5.13 |
Ionic | TM6 | E | 235 | 6x22 | G.S6 | H | 322 | G.S6.04 |
Polar | TM3 | S | 148 | 3x57 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | TM3 | S | 148 | 3x57 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | A | 367 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | E | 346 | G.H5.18 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | E | 346 | G.H5.18 |
Polar | TM3 | Y | 137 | 3x46 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | Y | 137 | 3x46 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | Y | 137 | 3x46 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | Y | 231 | - | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL3 | Y | 231 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | Y | 231 | - | G.H5 | K | 345 | G.H5.17 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM2 | V | 68 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | V | 68 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | V | 68 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | R | 245 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 245 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | R | 245 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | R | 245 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | M | 370 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | M | 370 | - | G.H3 | H | 256 | G.H3.15 |
Ionic | C-term | E | 366 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | E | 366 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | E | 366 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 144 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | E | 235 | 6x22 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | C-term | W | 329 | - | G.h4s6 | L | 312 | G.h4s6.03 |
Van-der-waals | C-term | W | 329 | - | G.h4s6 | L | 312 | G.h4s6.03 |
Polar | TM3 | S | 148 | 3x57 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | TM3 | S | 148 | 3x57 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.S3 | L | 194 | G.S3.01 |
Ionic | C-term | R | 324 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM6 | V | 241 | 6x28 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | V | 241 | 6x28 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 371 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | L | 371 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | I | 242 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | ICL2 | L | 151 | - | G.HN | E | 28 | G.HN.52 |
Polar | TM6 | E | 235 | 6x22 | G.S6 | S | 321 | G.S6.03 |
Ionic | TM6 | R | 237 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 237 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 237 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 237 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | A | 367 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM6 | N | 234 | 6x21 | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | TM6 | N | 234 | 6x21 | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | TM6 | E | 235 | 6x22 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM6 | E | 235 | 6x22 | G.S6 | Y | 320 | G.S6.02 |
Polar | C-term | T | 363 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | T | 363 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | C-term | L | 371 | - | G.H2 | I | 212 | G.H2.08 |