G12 - GPR148 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 H 162 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 H 162 4x39 G.HN R 52 G.HN.52
Hydrophobic TM3 V 150 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 S 249 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 E 245 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 I 251 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 I 251 - G.H5 L 375 G.H5.20
Polar TM6 R 258 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 258 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 258 6x29 G.H5 Q 381 G.H5.26
Polar TM2 Q 82 2x36 G.HN R 52 G.HN.52
Hydrophobic TM2 Q 82 2x36 G.HN R 52 G.HN.52
Van-der-waals TM2 Q 82 2x36 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 157 34x54 G.S1 V 58 G.S1.02
Hydrophobic ICL2 L 154 34x51 G.S1 V 58 G.S1.02
Polar ICL3 S 249 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 S 249 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 153 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 154 34x51 G.S3 F 223 G.S3.03
Hydrophobic ICL2 L 154 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 154 34x51 G.S3 I 221 G.S3.01
Polar H8 R 323 8x53 G.H5 M 379 G.H5.24
Hydrophobic H8 R 323 8x53 G.H5 M 379 G.H5.24
Van-der-waals H8 R 323 8x53 G.H5 M 379 G.H5.24
Hydrophobic TM3 A 149 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 T 146 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 157 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 157 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 A 246 - G.H5 L 375 G.H5.20
Hydrophobic TM3 V 150 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM4 S 161 4x38 G.HN R 52 G.HN.52
Hydrophobic TM6 G 255 6x26 G.H5 L 380 G.H5.25
Van-der-waals TM6 G 255 6x26 G.H5 L 380 G.H5.25
Polar ICL2 S 158 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 158 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 158 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 I 251 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 I 251 - G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 259 6x30 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 259 6x30 G.H5 L 380 G.H5.25
Hydrophobic TM2 Q 82 2x36 G.HN A 48 G.HN.48
Polar TM4 S 161 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 S 161 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 S 161 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 157 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 157 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 154 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 154 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 154 34x51 G.H5 V 366 G.H5.11
Van-der-waals TM6 R 258 6x29 G.H5 M 379 G.H5.24
Ionic TM2 E 83 2x37 G.hns1 R 55 G.hns1.02
Polar TM2 E 83 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 E 83 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 E 83 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 154 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 Y 156 34x53 G.H5 I 378 G.H5.23
Ionic ICL3 E 245 - G.H5 K 367 G.H5.12
Polar ICL3 E 245 - G.H5 K 367 G.H5.12
Van-der-waals ICL3 E 245 - G.H5 K 367 G.H5.12
Polar TM6 R 258 6x29 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 258 6x29 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 258 6x29 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 154 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 154 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL3 I 242 - G.H5 M 379 G.H5.24
Van-der-waals ICL3 I 242 - G.H5 M 379 G.H5.24
Hydrophobic TM6 L 263 6x34 G.H5 M 379 G.H5.24
Polar TM3 A 149 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 L 157 34x54 G.hns1 R 55 G.hns1.02
Polar TM6 A 259 6x30 G.H5 M 379 G.H5.24
Hydrophobic TM6 A 259 6x30 G.H5 M 379 G.H5.24
Polar H8 R 323 8x53 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 323 8x53 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 323 8x53 G.H5 Q 381 G.H5.26
Polar TM2 Y 86 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 Y 86 2x40 G.H5 Q 381 G.H5.26
Polar ICL2 F 159 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 H 145 3x49 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 153 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 K 367 G.H5.12
Polar TM6 T 262 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 262 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 262 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 Y 156 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 T 146 3x50 G.H5 M 379 G.H5.24
Polar H8 R 323 8x53 G.H5 L 380 G.H5.25
Van-der-waals H8 R 323 8x53 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 150 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 375 G.H5.20