Gs - GPR148 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 155 34x52 G.S3 V 217 G.S3.01
Polar TM2 Q 82 2x36 G.HN K 34 G.HN.51
Van-der-waals TM2 Q 82 2x36 G.HN K 34 G.HN.51
Hydrophobic ICL2 L 157 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 157 34x54 G.S1 H 41 G.S1.02
Hydrophobic H8 Y 324 8x54 G.H5 E 392 G.H5.24
Aromatic ICL2 Y 156 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 156 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 156 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 157 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 157 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 S 158 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 S 158 34x55 G.hns1 A 39 G.hns1.03
Polar ICL2 L 157 34x54 G.HN Q 35 G.HN.52
Van-der-waals ICL2 L 157 34x54 G.HN Q 35 G.HN.52
Hydrophobic TM3 V 150 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 153 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 153 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM6 T 262 6x33 G.H5 L 393 G.H5.25
Polar TM6 T 262 6x33 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 149 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 I 251 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 I 251 - G.H5 L 388 G.H5.20
Hydrophobic TM6 R 258 6x29 G.H5 L 393 G.H5.25
Polar TM2 H 85 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM2 H 85 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 H 85 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 263 6x34 G.H5 L 393 G.H5.25
Polar ICL2 L 154 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 154 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 154 34x51 G.S1 H 41 G.S1.02
Polar ICL2 S 158 34x55 G.HN Q 35 G.HN.52
Van-der-waals ICL2 S 158 34x55 G.HN Q 35 G.HN.52
Hydrophobic ICL2 L 157 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL3 I 242 - G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 154 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 154 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 154 34x51 G.H5 C 379 G.H5.11
Polar TM3 A 149 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 H 387 G.H5.19
Polar TM3 H 145 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 H 145 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 145 3x49 G.H5 Y 391 G.H5.23
Ionic ICL3 E 245 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 I 251 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 I 251 - G.H5 L 394 G.H5.26
Ionic TM6 R 258 6x29 G.H5 E 392 G.H5.24
Polar TM6 R 258 6x29 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 258 6x29 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 258 6x29 G.H5 E 392 G.H5.24
Polar ICL2 Y 156 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 156 34x53 G.H5 Y 391 G.H5.23
Polar TM6 T 262 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 262 6x33 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 262 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM3 T 146 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 157 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 V 150 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 Q 384 G.H5.16
Polar TM6 A 259 6x30 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 259 6x30 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 259 6x30 G.H5 L 393 G.H5.25
Polar ICL2 R 155 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 155 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 155 34x52 G.s2s3 D 215 G.s2s3.01
Polar H8 R 323 8x53 G.H5 E 392 G.H5.24
Hydrophobic H8 R 323 8x53 G.H5 E 392 G.H5.24
Van-der-waals H8 R 323 8x53 G.H5 E 392 G.H5.24
Hydrophobic TM3 T 146 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 154 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 154 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 P 153 34x50 G.H5 I 383 G.H5.15
Polar TM6 R 258 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 258 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 258 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM2 H 85 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 85 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 154 34x51 G.H5 R 380 G.H5.12
Polar H8 R 325 8x55 G.H5 E 392 G.H5.24
Van-der-waals H8 R 325 8x55 G.H5 E 392 G.H5.24
Polar ICL3 S 249 - G.H5 R 385 G.H5.17
Polar ICL3 E 245 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 E 245 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 E 245 - G.H5 Q 384 G.H5.16
Polar TM4 S 161 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 S 161 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 S 161 4x38 G.HN Q 35 G.HN.52
Polar TM3 V 150 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 150 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 157 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 154 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 154 34x51 G.H5 I 383 G.H5.15
Polar ICL2 M 160 34x57 G.HN Q 35 G.HN.52
Ionic TM2 E 83 2x37 G.hns1 R 38 G.hns1.02
Polar TM2 E 83 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 E 83 2x37 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 E 83 2x37 G.hns1 R 38 G.hns1.02