GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL1 | K | 78 | - | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | ICL1 | K | 78 | - | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | V | 151 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL3 | A | 275 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Hydrophobic | ICL3 | A | 275 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Van-der-waals | ICL3 | A | 275 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL1 | W | 74 | - | G.h3s5 | R | 270 | G.h3s5.01 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM6 | Q | 292 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | Q | 292 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL1 | W | 74 | - | G.H3 | L | 269 | G.H3.18 |
Hydrophobic | ICL1 | W | 74 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | ICL1 | W | 74 | - | G.H3 | R | 267 | G.H3.16 |
Polar | TM3 | E | 146 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | E | 146 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | E | 146 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL3 | R | 279 | - | G.H5 | R | 360 | G.H5.05 |
Van-der-waals | ICL3 | R | 279 | - | G.H5 | R | 360 | G.H5.05 |
Ionic | ICL1 | R | 79 | - | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | P | 277 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Van-der-waals | ICL3 | P | 277 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL1 | W | 74 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | ICL1 | W | 74 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM6 | S | 284 | 6x24 | G.H5 | R | 372 | G.H5.17 |
Polar | C-term | Y | 403 | - | H.HA | T | 99 | H.HA.28 |
Van-der-waals | C-term | Y | 403 | - | H.HA | T | 99 | H.HA.28 |
Polar | ICL1 | K | 78 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL1 | K | 78 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL1 | K | 78 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL1 | R | 79 | - | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | ICL1 | R | 79 | - | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | ICL1 | W | 74 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Van-der-waals | ICL1 | W | 74 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Polar | H8 | Q | 356 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | Q | 356 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | Q | 356 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | R | 147 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Polar | ICL2 | P | 154 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | H | 374 | G.H5.19 |
Polar | ICL3 | P | 277 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Hydrophobic | ICL3 | P | 277 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Van-der-waals | ICL3 | P | 277 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM6 | K | 290 | 6x30 | G.H5 | Q | 371 | G.H5.16 |
Ionic | H8 | D | 359 | 8x50 | G.H5 | K | 376 | G.H5.21 |
Polar | H8 | D | 359 | 8x50 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | H8 | D | 359 | 8x50 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | H8 | D | 359 | 8x50 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM2 | L | 86 | 2x43 | G.H5 | E | 379 | G.H5.24 |
Polar | TM7 | Y | 352 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM7 | Y | 352 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | Y | 352 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL3 | P | 277 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | P | 277 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | P | 277 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | TM6 | K | 290 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | A | 285 | 6x25 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | W | 273 | 5x79 | G.hgh4 | P | 313 | G.hgh4.16 |
Polar | TM6 | S | 293 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | S | 293 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | S | 293 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | Y | 403 | - | H.hahb | I | 101 | H.hahb.01 |