Gi2 - GPR151 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.8
PAE mean: 22.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term F 389 - H.HA S 75 H.HA.13
Van-der-waals C-term F 389 - H.HA S 75 H.HA.13
Hydrophobic TM6 S 245 6x30 G.H5 L 354 G.H5.25
Hydrophobic C-term W 407 - G.h2s4 F 216 G.h2s4.01
Ionic C-term D 385 - G.H1 K 51 G.H1.06
Polar C-term D 385 - G.H1 K 51 G.H1.06
Hydrophobic C-term D 385 - G.H1 K 51 G.H1.06
Van-der-waals C-term D 385 - G.H1 K 51 G.H1.06
Polar TM6 R 240 6x25 G.H5 N 348 G.H5.19
Hydrophobic TM6 R 240 6x25 G.H5 N 348 G.H5.19
Van-der-waals TM6 R 240 6x25 G.H5 N 348 G.H5.19
Polar TM2 H 74 2x40 G.H5 L 354 G.H5.25
Hydrophobic TM2 H 74 2x40 G.H5 L 354 G.H5.25
Van-der-waals TM2 H 74 2x40 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 248 6x33 G.H5 F 355 G.H5.26
Polar TM5 Y 226 5x62 G.HN R 24 G.HN.48
Van-der-waals TM5 Y 226 5x62 G.HN R 24 G.HN.48
Polar C-term D 385 - H.HA Y 69 H.HA.07
Hydrophobic C-term D 385 - H.HA Y 69 H.HA.07
Van-der-waals C-term D 385 - H.HA Y 69 H.HA.07
Van-der-waals C-term I 380 - H.HA Q 68 H.HA.06
Hydrophobic TM6 V 248 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 248 6x33 G.H5 L 354 G.H5.25
Hydrophobic C-term Q 388 - G.hfs2 T 182 G.hfs2.05
Ionic C-term E 408 - G.H2 R 209 G.H2.04
Hydrophobic TM6 L 239 6x24 G.HN G 27 G.HN.51
Van-der-waals TM6 L 239 6x24 G.HN G 27 G.HN.51
Hydrophobic TM3 Y 139 3x53 G.H5 L 354 G.H5.25
Hydrophobic TM6 M 251 6x36 G.H5 F 355 G.H5.26
Hydrophobic C-term P 406 - G.H2 R 206 G.H2.01
Polar C-term L 383 - H.HA Q 68 H.HA.06
Hydrophobic C-term L 383 - H.HA Q 68 H.HA.06
Van-der-waals C-term L 383 - H.HA Q 68 H.HA.06
Hydrophobic TM5 K 230 5x66 G.HN R 24 G.HN.48
Van-der-waals TM5 K 230 5x66 G.HN R 24 G.HN.48
Polar C-term R 393 - H.HA S 75 H.HA.13
Hydrophobic C-term R 393 - H.HA S 75 H.HA.13
Van-der-waals C-term R 393 - H.HA S 75 H.HA.13
Polar TM6 N 241 6x26 G.H5 C 352 G.H5.23
Hydrophobic TM6 N 241 6x26 G.H5 C 352 G.H5.23
Van-der-waals TM6 N 241 6x26 G.H5 C 352 G.H5.23
Hydrophobic TM6 I 243 6x28 G.hns1 A 31 G.hns1.02
Van-der-waals TM6 I 243 6x28 G.hns1 A 31 G.hns1.02
Hydrophobic C-term W 390 - H.HA A 71 H.HA.09
Van-der-waals C-term W 390 - H.HA A 71 H.HA.09
Polar C-term P 381 - H.HA Q 68 H.HA.06
Van-der-waals C-term P 381 - H.HA Q 68 H.HA.06
Ionic TM6 K 246 6x31 G.HN E 28 G.HN.52
Polar TM6 K 246 6x31 G.HN E 28 G.HN.52
Van-der-waals TM6 K 246 6x31 G.HN E 28 G.HN.52
Hydrophobic TM6 R 240 6x25 G.H5 L 349 G.H5.20
Van-der-waals TM6 R 240 6x25 G.H5 L 349 G.H5.20
Hydrophobic C-term W 390 - H.hbhc Q 117 H.hbhc.11
Hydrophobic C-term W 407 - G.H3 I 254 G.H3.12
Van-der-waals C-term W 407 - G.H3 I 254 G.H3.12
Ionic C-term R 393 - H.hbhc E 115 H.hbhc.03
Polar C-term R 393 - H.hbhc E 115 H.hbhc.03
Hydrophobic C-term R 393 - H.hbhc E 115 H.hbhc.03
Van-der-waals C-term R 393 - H.hbhc E 115 H.hbhc.03
Polar C-term Q 388 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term Q 388 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term Q 388 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term D 403 - G.H2 R 206 G.H2.01
Van-der-waals C-term D 403 - G.H2 R 206 G.H2.01
Hydrophobic C-term W 407 - G.H3 S 253 G.H3.11
Van-der-waals C-term W 407 - G.H3 S 253 G.H3.11
Ionic C-term E 410 - G.H2 K 210 G.H2.05
Hydrophobic C-term I 382 - H.HA Q 68 H.HA.06
Van-der-waals C-term I 382 - H.HA Q 68 H.HA.06
Hydrophobic TM2 I 73 2x39 G.H5 L 354 G.H5.25
Van-der-waals TM2 I 73 2x39 G.H5 L 354 G.H5.25
Hydrophobic C-term W 407 - G.H3 N 257 G.H3.15
Van-der-waals C-term W 407 - G.H3 N 257 G.H3.15
Hydrophobic H8 S 310 8x47 G.H5 F 355 G.H5.26
Van-der-waals H8 S 310 8x47 G.H5 F 355 G.H5.26
Hydrophobic C-term W 407 - G.H2 R 209 G.H2.04
Van-der-waals C-term W 407 - G.H2 R 209 G.H2.04
Polar TM2 I 73 2x39 G.H5 G 353 G.H5.24
Hydrophobic TM2 I 73 2x39 G.H5 G 353 G.H5.24
Hydrophobic ICL3 Q 237 - G.h2s4 G 218 G.h2s4.03
Van-der-waals ICL3 Q 237 - G.h2s4 G 218 G.h2s4.03
Polar C-term P 351 - G.H3 K 258 G.H3.16
Hydrophobic TM6 R 244 6x29 G.H5 L 354 G.H5.25
Polar TM3 Y 139 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 Y 139 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 Y 139 3x53 G.H5 C 352 G.H5.23
Hydrophobic C-term W 407 - G.H2 W 212 G.H2.07
Van-der-waals C-term W 407 - G.H2 W 212 G.H2.07
Hydrophobic H8 E 312 8x49 G.H5 F 355 G.H5.26
Van-der-waals H8 E 312 8x49 G.H5 F 355 G.H5.26
Hydrophobic C-term F 389 - H.HA V 72 H.HA.10
Hydrophobic C-term W 390 - H.hbhc G 118 H.hbhc.12
Hydrophobic C-term D 385 - G.hfs2 V 180 G.hfs2.03
Van-der-waals C-term D 385 - G.hfs2 V 180 G.hfs2.03
Hydrophobic TM6 L 239 6x24 G.hns1 A 31 G.hns1.02
Van-der-waals TM6 L 239 6x24 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 I 243 6x28 G.hns1 R 32 G.hns1.03
Van-der-waals TM6 I 243 6x28 G.hns1 R 32 G.hns1.03
Hydrophobic C-term L 383 - H.HA Y 69 H.HA.07
Van-der-waals C-term L 383 - H.HA Y 69 H.HA.07
Hydrophobic C-term V 386 - H.HA Y 69 H.HA.07
Van-der-waals C-term V 386 - H.HA Y 69 H.HA.07
Hydrophobic C-term L 383 - H.HA E 65 H.HA.03
Hydrophobic TM6 L 239 6x24 G.hns1 A 30 G.hns1.01
Van-der-waals TM6 L 239 6x24 G.hns1 A 30 G.hns1.01
Polar C-term D 403 - G.H2 S 207 G.H2.02
Hydrophobic C-term D 403 - G.H2 S 207 G.H2.02
Van-der-waals C-term D 403 - G.H2 S 207 G.H2.02
Polar TM3 Y 139 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM3 Y 139 3x53 G.H5 D 351 G.H5.22
Polar ICL2 Q 146 34x53 G.H5 D 351 G.H5.22
Van-der-waals ICL2 Q 146 34x53 G.H5 D 351 G.H5.22
Polar TM6 R 240 6x25 G.H5 I 344 G.H5.15
Hydrophobic TM6 R 240 6x25 G.H5 I 344 G.H5.15
Van-der-waals TM6 R 240 6x25 G.H5 I 344 G.H5.15
Hydrophobic C-term P 404 - G.H2 K 210 G.H2.05
Polar TM6 R 244 6x29 G.H5 K 350 G.H5.21
Hydrophobic TM6 R 244 6x29 G.H5 K 350 G.H5.21
Van-der-waals TM6 R 244 6x29 G.H5 K 350 G.H5.21
Polar ICL2 Q 146 34x53 G.h3s5 D 262 G.h3s5.02
Hydrophobic ICL2 Q 146 34x53 G.h3s5 D 262 G.h3s5.02
Van-der-waals ICL2 Q 146 34x53 G.h3s5 D 262 G.h3s5.02
Polar TM6 R 240 6x25 G.hns1 A 31 G.hns1.02
Hydrophobic C-term E 408 - G.H3 L 250 G.H3.08
Van-der-waals C-term E 408 - G.H3 L 250 G.H3.08
Polar ICL3 T 234 - G.HN L 23 G.HN.47
Hydrophobic ICL3 T 234 - G.HN L 23 G.HN.47
Van-der-waals ICL3 T 234 - G.HN L 23 G.HN.47
Polar C-term E 408 - G.H3 S 253 G.H3.11
Hydrophobic C-term E 408 - G.H3 S 253 G.H3.11
Van-der-waals C-term E 408 - G.H3 S 253 G.H3.11
Polar TM6 R 244 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 244 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 244 6x29 G.H5 F 355 G.H5.26
Aromatic TM2 H 74 2x40 G.H5 F 355 G.H5.26
Hydrophobic TM2 H 74 2x40 G.H5 F 355 G.H5.26
Van-der-waals TM2 H 74 2x40 G.H5 F 355 G.H5.26
Polar ICL3 G 233 - G.HN G 27 G.HN.51
Hydrophobic ICL3 G 233 - G.HN G 27 G.HN.51
Van-der-waals ICL3 G 233 - G.HN G 27 G.HN.51
Hydrophobic C-term F 389 - G.hfs2 V 180 G.hfs2.03
Polar TM6 R 244 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM6 R 244 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 R 244 6x29 G.H5 L 349 G.H5.20
Aromatic H8 F 313 8x50 G.H5 F 355 G.H5.26
Hydrophobic H8 F 313 8x50 G.H5 F 355 G.H5.26
Van-der-waals H8 F 313 8x50 G.H5 F 355 G.H5.26
Polar C-term Q 388 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term Q 388 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term Q 388 - G.hfs2 T 183 G.hfs2.06
Hydrophobic ICL3 T 236 - G.hns1 A 30 G.hns1.01
Hydrophobic C-term F 389 - H.HA A 71 H.HA.09
Hydrophobic ICL3 Q 237 - G.h2s4 E 217 G.h2s4.02
Van-der-waals ICL3 Q 237 - G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term P 404 - G.H2 S 207 G.H2.02
Van-der-waals C-term P 404 - G.H2 S 207 G.H2.02
Hydrophobic C-term I 380 - H.HA E 64 H.HA.02
Hydrophobic C-term L 383 - G.h1ha Y 61 G.h1ha.04
Hydrophobic C-term V 386 - H.HA Q 68 H.HA.06
Polar TM2 S 71 2x37 G.H5 L 354 G.H5.25
Hydrophobic TM2 S 71 2x37 G.H5 L 354 G.H5.25
Polar TM2 S 71 2x37 G.H5 G 353 G.H5.24
Hydrophobic TM2 S 71 2x37 G.H5 G 353 G.H5.24
Van-der-waals TM2 S 71 2x37 G.H5 G 353 G.H5.24
Hydrophobic TM6 R 244 6x29 G.H5 C 352 G.H5.23
Van-der-waals TM6 R 244 6x29 G.H5 C 352 G.H5.23
Van-der-waals TM6 N 241 6x26 G.H5 N 348 G.H5.19
Polar TM6 R 240 6x25 G.H5 I 345 G.H5.16
Hydrophobic TM6 R 240 6x25 G.H5 I 345 G.H5.16
Van-der-waals TM6 R 240 6x25 G.H5 I 345 G.H5.16
Van-der-waals ICL3 T 236 - G.S1 E 33 G.S1.01