Gi3 - GPR151 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.7
PAE mean: 25.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term V 386 - H.HA V 72 H.HA.10
Hydrophobic C-term P 404 - G.H2 S 206 G.H2.02
Van-der-waals C-term P 404 - G.H2 S 206 G.H2.02
Ionic TM6 R 240 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 240 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 240 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 240 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 248 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 V 248 6x33 G.H5 Y 354 G.H5.26
Hydrophobic C-term L 383 - H.HA E 65 H.HA.03
Hydrophobic ICL2 A 144 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 S 148 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 S 148 34x55 G.HN E 28 G.HN.52
Hydrophobic C-term W 407 - G.H2 R 208 G.H2.04
Van-der-waals C-term W 407 - G.H2 R 208 G.H2.04
Hydrophobic TM3 V 135 3x49 G.H5 L 353 G.H5.25
Van-der-waals TM3 V 135 3x49 G.H5 L 353 G.H5.25
Polar TM3 Y 139 3x53 G.H5 K 345 G.H5.17
Van-der-waals TM3 Y 139 3x53 G.H5 K 345 G.H5.17
Hydrophobic C-term V 386 - H.HA Q 68 H.HA.06
Hydrophobic C-term F 389 - H.HA S 75 H.HA.13
Van-der-waals C-term F 389 - H.HA S 75 H.HA.13
Hydrophobic C-term Q 388 - G.hfs2 T 181 G.hfs2.05
Van-der-waals C-term Q 388 - G.hfs2 T 181 G.hfs2.05
Polar C-term Q 388 - G.hfs2 T 182 G.hfs2.06
Hydrophobic C-term Q 388 - G.hfs2 T 182 G.hfs2.06
Van-der-waals C-term Q 388 - G.hfs2 T 182 G.hfs2.06
Ionic C-term E 392 - G.hfs2 K 180 G.hfs2.04
Hydrophobic C-term E 392 - G.hfs2 K 180 G.hfs2.04
Van-der-waals C-term E 392 - G.hfs2 K 180 G.hfs2.04
Hydrophobic C-term D 403 - G.H2 R 205 G.H2.01
Van-der-waals C-term D 403 - G.H2 R 205 G.H2.01
Ionic C-term D 385 - G.H1 K 51 G.H1.06
Polar C-term D 385 - G.H1 K 51 G.H1.06
Hydrophobic C-term D 385 - G.H1 K 51 G.H1.06
Van-der-waals C-term D 385 - G.H1 K 51 G.H1.06
Polar C-term L 383 - H.HA Q 68 H.HA.06
Hydrophobic C-term L 383 - H.HA Q 68 H.HA.06
Van-der-waals C-term L 383 - H.HA Q 68 H.HA.06
Polar TM6 R 244 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 R 244 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 244 6x29 G.H5 K 345 G.H5.17
Hydrophobic H8 E 315 8x52 G.h4s6 T 316 G.h4s6.10
Van-der-waals H8 E 315 8x52 G.h4s6 T 316 G.h4s6.10
Hydrophobic C-term W 407 - G.H3 N 256 G.H3.15
Van-der-waals C-term W 407 - G.H3 N 256 G.H3.15
Hydrophobic ICL2 A 144 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 A 144 34x51 G.S3 L 194 G.S3.01
Polar TM6 R 240 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM6 R 240 6x25 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 240 6x25 G.H5 K 345 G.H5.17
Hydrophobic C-term I 382 - H.HA Q 68 H.HA.06
Polar TM4 H 150 4x38 G.HN R 24 G.HN.48
Aromatic TM4 H 150 4x38 G.HN R 24 G.HN.48
Hydrophobic TM4 H 150 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 H 150 4x38 G.HN R 24 G.HN.48
Hydrophobic ICL1 P 70 - G.H5 C 351 G.H5.23
Van-der-waals ICL1 P 70 - G.H5 C 351 G.H5.23
Polar ICL1 K 69 - G.HN G 27 G.HN.51
Hydrophobic TM3 Y 139 3x53 G.H5 L 353 G.H5.25
Polar C-term E 408 - G.H3 S 252 G.H3.11
Hydrophobic C-term E 408 - G.H3 S 252 G.H3.11
Van-der-waals C-term E 408 - G.H3 S 252 G.H3.11
Polar TM2 S 71 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 71 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 71 2x37 G.H5 C 351 G.H5.23
Hydrophobic ICL3 T 236 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 T 236 - G.H5 F 334 G.H5.06
Van-der-waals H8 E 315 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 P 143 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 143 34x50 G.H5 I 344 G.H5.16
Hydrophobic C-term L 383 - H.HA Y 69 H.HA.07
Van-der-waals C-term L 383 - H.HA Y 69 H.HA.07
Hydrophobic C-term F 389 - G.hfs2 V 179 G.hfs2.03
Hydrophobic C-term L 383 - G.h1ha Y 61 G.h1ha.04
Hydrophobic C-term F 389 - H.HA V 72 H.HA.10
Hydrophobic C-term W 407 - G.h2s4 F 215 G.h2s4.01
Hydrophobic TM2 M 72 2x38 G.H5 L 353 G.H5.25
Hydrophobic TM2 I 73 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 I 73 2x39 G.H5 L 353 G.H5.25
Polar TM6 N 238 6x23 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 238 6x23 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 238 6x23 G.H5 D 341 G.H5.13
Hydrophobic C-term P 404 - G.H2 K 209 G.H2.05
Van-der-waals C-term P 404 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 Q 146 34x53 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 Q 146 34x53 G.hns1 K 32 G.hns1.03
Polar C-term Q 388 - G.hfs2 K 180 G.hfs2.04
Hydrophobic C-term Q 388 - G.hfs2 K 180 G.hfs2.04
Van-der-waals C-term Q 388 - G.hfs2 K 180 G.hfs2.04
Hydrophobic TM6 R 244 6x29 G.H5 K 349 G.H5.21
Van-der-waals TM6 R 244 6x29 G.H5 K 349 G.H5.21
Polar ICL3 Q 237 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 Q 237 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 Q 237 - G.H5 F 334 G.H5.06
Polar ICL3 Q 237 - G.H5 Q 333 G.H5.05
Polar TM2 S 71 2x37 G.H5 G 352 G.H5.24
Hydrophobic TM2 S 71 2x37 G.H5 G 352 G.H5.24
Van-der-waals TM2 S 71 2x37 G.H5 G 352 G.H5.24
Polar ICL3 Q 237 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 Q 237 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 Q 237 - G.H5 D 337 G.H5.09
Polar TM3 Y 139 3x53 G.H5 I 344 G.H5.16
Polar TM2 H 74 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 H 74 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 H 74 2x40 G.H5 G 352 G.H5.24
Polar TM6 N 241 6x26 G.H5 V 342 G.H5.14
Hydrophobic TM6 N 241 6x26 G.H5 V 342 G.H5.14
Van-der-waals TM6 N 241 6x26 G.H5 V 342 G.H5.14
Polar C-term I 405 - G.H2 K 209 G.H2.05
Hydrophobic C-term I 405 - G.H2 K 209 G.H2.05
Van-der-waals C-term I 405 - G.H2 K 209 G.H2.05
Polar TM6 R 240 6x25 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 240 6x25 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 240 6x25 G.S6 Y 320 G.S6.02
Hydrophobic C-term W 390 - H.HA V 71 H.HA.09
Van-der-waals C-term W 390 - H.HA V 71 H.HA.09
Ionic TM4 H 150 4x38 G.HN E 28 G.HN.52
Polar TM4 H 150 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 H 150 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 H 150 4x38 G.HN E 28 G.HN.52
Polar TM6 N 241 6x26 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 241 6x26 G.H5 Y 354 G.H5.26
Polar TM2 S 71 2x37 G.H5 L 353 G.H5.25
Hydrophobic TM2 S 71 2x37 G.H5 L 353 G.H5.25
Van-der-waals TM2 S 71 2x37 G.H5 L 353 G.H5.25
Polar TM6 N 241 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 N 241 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 N 241 6x26 G.H5 K 345 G.H5.17
Hydrophobic ICL3 Q 237 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 Q 237 - G.H5 A 338 G.H5.10
Hydrophobic C-term E 408 - G.H3 L 249 G.H3.08
Van-der-waals C-term E 408 - G.H3 L 249 G.H3.08
Van-der-waals C-term I 380 - H.HA Q 68 H.HA.06
Hydrophobic C-term W 407 - G.H3 S 252 G.H3.11
Van-der-waals C-term W 407 - G.H3 S 252 G.H3.11
Polar C-term D 385 - H.HA Y 69 H.HA.07
Hydrophobic C-term D 385 - H.HA Y 69 H.HA.07
Van-der-waals C-term D 385 - H.HA Y 69 H.HA.07
Hydrophobic ICL2 S 148 34x55 G.hns1 A 31 G.hns1.02
Polar TM6 R 244 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 244 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 244 6x29 G.H5 Y 354 G.H5.26
Polar C-term P 381 - H.HA Q 68 H.HA.06
Van-der-waals C-term P 381 - H.HA Q 68 H.HA.06
Ionic C-term R 393 - H.hbhc E 115 H.hbhc.03
Polar C-term R 393 - H.hbhc E 115 H.hbhc.03
Hydrophobic C-term R 393 - H.hbhc E 115 H.hbhc.03
Van-der-waals C-term R 393 - H.hbhc E 115 H.hbhc.03
Hydrophobic ICL2 A 144 34x51 G.H5 I 344 G.H5.16
Aromatic TM3 Y 139 3x53 G.H5 Y 354 G.H5.26
Hydrophobic TM3 Y 139 3x53 G.H5 Y 354 G.H5.26
Van-der-waals TM3 Y 139 3x53 G.H5 Y 354 G.H5.26
Hydrophobic C-term V 386 - H.HA Y 69 H.HA.07
Hydrophobic C-term D 385 - G.hfs2 V 179 G.hfs2.03
Van-der-waals C-term D 385 - G.hfs2 V 179 G.hfs2.03
Polar TM6 S 245 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM6 S 245 6x30 G.H5 Y 354 G.H5.26
Van-der-waals TM6 S 245 6x30 G.H5 Y 354 G.H5.26
Polar C-term D 403 - G.H2 S 206 G.H2.02
Hydrophobic C-term D 403 - G.H2 S 206 G.H2.02
Van-der-waals C-term D 403 - G.H2 S 206 G.H2.02
Van-der-waals ICL1 K 69 - G.H5 C 351 G.H5.23
Hydrophobic C-term W 407 - G.H3 I 253 G.H3.12
Van-der-waals C-term W 407 - G.H3 I 253 G.H3.12
Hydrophobic H8 E 312 8x49 G.H5 Y 354 G.H5.26
Van-der-waals H8 E 312 8x49 G.H5 Y 354 G.H5.26
Polar TM6 N 241 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 241 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 241 6x26 G.H5 D 341 G.H5.13
Polar TM6 N 238 6x23 G.H5 A 338 G.H5.10
Van-der-waals TM6 N 238 6x23 G.H5 A 338 G.H5.10
Hydrophobic C-term I 380 - H.HA D 64 H.HA.02
Van-der-waals C-term I 380 - H.HA D 64 H.HA.02
Hydrophobic C-term W 407 - G.H2 W 211 G.H2.07
Van-der-waals C-term W 407 - G.H2 W 211 G.H2.07
Polar ICL2 Q 146 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 146 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 146 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 146 34x53 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Q 146 34x53 G.S3 L 194 G.S3.01
Hydrophobic C-term F 389 - H.HA V 71 H.HA.09
Van-der-waals C-term F 389 - H.HA V 71 H.HA.09
Hydrophobic ICL2 A 144 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 A 144 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM3 Y 139 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 Y 139 3x53 G.H5 L 348 G.H5.20