GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 69.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 19.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ECL2 | F | 185 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ECL2 | W | 176 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ECL2 | W | 176 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ECL2 | L | 179 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM1 | Y | 26 | 1x29 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM1 | Y | 26 | 1x29 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL2 | W | 175 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ECL2 | W | 175 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM7 | L | 273 | 7x30 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL2 | W | 175 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ECL2 | W | 175 | - | G.H5 | L | 367 | G.H5.16 |
Polar | ECL2 | Y | 177 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ECL2 | Y | 177 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ECL2 | Y | 177 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ECL2 | F | 185 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ECL2 | A | 173 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ECL2 | A | 173 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM7 | W | 274 | 7x31 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM7 | W | 274 | 7x31 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM1 | P | 27 | 1x30 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM1 | P | 27 | 1x30 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ECL2 | F | 185 | - | G.H5 | L | 374 | G.H5.23 |
Polar | TM1 | S | 25 | 1x28 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM1 | S | 25 | 1x28 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM1 | S | 25 | 1x28 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | N-term | L | 20 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | ECL2 | W | 176 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ECL2 | W | 176 | - | G.H5 | L | 367 | G.H5.16 |
Polar | ECL2 | D | 187 | - | G.HN | S | 39 | G.HN.48 |
Hydrophobic | ECL2 | D | 187 | - | G.HN | S | 39 | G.HN.48 |
Van-der-waals | ECL2 | D | 187 | - | G.HN | S | 39 | G.HN.48 |
Polar | ECL2 | W | 186 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ECL2 | W | 186 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM7 | W | 274 | 7x31 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | L | 277 | 7x34 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | L | 277 | 7x34 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL2 | W | 176 | - | G.S3 | F | 218 | G.S3.03 |
Van-der-waals | ECL2 | W | 176 | - | G.S3 | F | 218 | G.S3.03 |
Polar | ECL2 | V | 174 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ECL2 | V | 174 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ECL2 | L | 183 | 45x51 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ECL2 | V | 174 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ECL2 | Y | 177 | - | G.H5 | K | 363 | G.H5.12 |
Polar | TM6 | Y | 260 | 6x58 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | Y | 260 | 6x58 | G.H5 | Q | 377 | G.H5.26 |
Ionic | TM5 | E | 190 | 5x37 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM5 | E | 190 | 5x37 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM5 | E | 190 | 5x37 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM5 | E | 190 | 5x37 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM6 | Y | 260 | 6x58 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | Y | 260 | 6x58 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | Y | 260 | 6x58 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM1 | Y | 26 | 1x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | F | 263 | 6x61 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL2 | W | 176 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ECL2 | W | 176 | - | G.S3 | V | 216 | G.S3.01 |
Polar | TM7 | Y | 271 | 7x28 | G.h4s6 | Q | 337 | G.h4s6.11 |
Ionic | TM7 | E | 275 | 7x32 | G.H5 | K | 372 | G.H5.21 |
Polar | TM7 | E | 275 | 7x32 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM7 | E | 275 | 7x32 | G.H5 | K | 372 | G.H5.21 |
Polar | TM7 | Y | 271 | 7x28 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM7 | Y | 271 | 7x28 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM7 | Y | 271 | 7x28 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ECL2 | W | 175 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ECL2 | W | 175 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ECL2 | W | 176 | - | G.S2 | I | 213 | G.S2.08 |
Van-der-waals | ECL2 | W | 176 | - | G.S2 | I | 213 | G.S2.08 |
Hydrophobic | ECL2 | I | 181 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL2 | L | 183 | 45x51 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ECL2 | L | 183 | 45x51 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ECL2 | W | 176 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ECL2 | W | 176 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ECL2 | D | 184 | 45x52 | G.hns1 | K | 46 | G.hns1.02 |
Aromatic | ECL2 | F | 185 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ECL2 | F | 185 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ECL2 | F | 185 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM5 | R | 194 | 5x41 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM5 | R | 194 | 5x41 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM7 | W | 274 | 7x31 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | W | 274 | 7x31 | G.H5 | M | 375 | G.H5.24 |
Polar | ECL2 | D | 187 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ECL2 | D | 187 | - | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ECL2 | D | 187 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM1 | Y | 26 | 1x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM1 | Y | 26 | 1x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ECL2 | W | 175 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ECL2 | W | 175 | - | G.H5 | L | 374 | G.H5.23 |
Polar | ECL2 | D | 187 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ECL2 | D | 187 | - | G.HN | T | 43 | G.HN.52 |
Polar | ECL3 | S | 269 | - | G.h3s5 | S | 282 | G.h3s5.01 |
Polar | N-term | H | 14 | - | G.H4 | R | 320 | G.H4.05 |
Aromatic | N-term | H | 14 | - | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | N-term | H | 14 | - | G.H4 | R | 320 | G.H4.05 |
Polar | ECL2 | Y | 177 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | ECL3 | S | 269 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | ECL3 | S | 269 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | ECL3 | S | 269 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM1 | P | 27 | 1x30 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM1 | P | 27 | 1x30 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM1 | P | 27 | 1x30 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ECL2 | W | 175 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ECL2 | W | 175 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ECL2 | S | 188 | - | G.HN | K | 42 | G.HN.51 |
Ionic | TM5 | E | 190 | 5x37 | G.HN | K | 42 | G.HN.51 |
Polar | TM5 | E | 190 | 5x37 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM5 | E | 190 | 5x37 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM1 | P | 27 | 1x30 | G.H5 | L | 371 | G.H5.20 |