Gt2 - GPR157 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 19.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 H 219 6x29 G.H5 K 345 G.H5.17
Polar TM6 S 221 6x31 G.H5 K 345 G.H5.17
Hydrophobic TM6 S 221 6x31 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 221 6x31 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 100 3x46 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 100 3x46 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 113 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 R 113 - G.S3 L 194 G.S3.01
Hydrophobic TM2 R 47 2x40 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 218 6x28 G.H5 A 338 G.H5.10
Polar ICL2 R 113 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 113 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 113 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 S 107 3x53 G.H5 I 344 G.H5.16
Van-der-waals TM3 S 107 3x53 G.H5 I 344 G.H5.16
Hydrophobic TM2 A 46 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 A 46 2x39 G.H5 L 353 G.H5.25
Ionic TM6 H 219 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 219 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 219 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 222 6x32 G.H5 K 349 G.H5.21
Hydrophobic TM2 A 46 2x39 G.H5 L 348 G.H5.20
Polar H8 T 283 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 T 283 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 T 283 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 108 3x54 G.H5 F 354 G.H5.26
Van-der-waals TM3 I 108 3x54 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 223 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 223 6x33 G.H5 F 354 G.H5.26
Polar H8 T 283 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM2 R 45 2x38 G.hns1 K 32 G.hns1.03
Van-der-waals TM2 R 45 2x38 G.hns1 K 32 G.hns1.03
Polar TM2 R 47 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 47 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 47 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 104 3x50 G.H5 L 353 G.H5.25
Polar ICL2 R 113 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 113 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 R 113 - G.H5 I 344 G.H5.16
Hydrophobic TM3 L 104 3x50 G.H5 F 354 G.H5.26
Hydrophobic TM7 F 279 7x53 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 279 7x53 G.H5 G 352 G.H5.24
Ionic TM6 R 215 6x25 G.H5 D 341 G.H5.13
Polar TM6 R 215 6x25 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 215 6x25 G.H5 D 341 G.H5.13
Hydrophobic TM6 I 230 6x40 G.H5 L 353 G.H5.25
Polar TM2 R 47 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 47 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 47 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 47 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM3 S 107 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM2 L 50 2x43 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 221 6x31 G.H5 K 349 G.H5.21
Hydrophobic TM6 A 223 6x33 G.H5 K 345 G.H5.17
Van-der-waals TM6 A 223 6x33 G.H5 K 345 G.H5.17
Hydrophobic TM7 F 279 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 F 279 7x53 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 227 6x37 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 227 6x37 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 111 3x57 G.H5 I 344 G.H5.16
Polar TM6 K 226 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 226 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 108 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 111 3x57 G.s2s3 K 192 G.s2s3.01
Van-der-waals TM3 A 111 3x57 G.s2s3 K 192 G.s2s3.01
Ionic TM2 R 45 2x38 G.HN D 28 G.HN.52
Polar TM2 R 45 2x38 G.HN D 28 G.HN.52
Polar TM4 G 114 4x35 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM4 G 114 4x35 G.s2s3 D 193 G.s2s3.02
Van-der-waals TM4 G 114 4x35 G.s2s3 D 193 G.s2s3.02
Polar TM6 K 226 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 226 6x36 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 F 354 G.H5.26
Hydrophobic H8 R 284 8x48 G.h4s6 V 316 G.h4s6.10
Van-der-waals H8 R 284 8x48 G.h4s6 V 316 G.h4s6.10
Hydrophobic TM2 A 46 2x39 G.H5 C 351 G.H5.23
Ionic TM6 D 224 6x34 G.H5 K 345 G.H5.17
Polar TM6 D 224 6x34 G.H5 K 345 G.H5.17
Hydrophobic TM6 D 224 6x34 G.H5 K 345 G.H5.17
Van-der-waals TM6 D 224 6x34 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 108 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 108 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 113 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 R 113 - G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 K 226 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 226 6x36 G.H5 L 353 G.H5.25
Ionic TM4 D 118 4x39 G.hns1 K 32 G.hns1.03
Polar TM2 S 44 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 44 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 44 2x37 G.H5 C 351 G.H5.23