G15 - GPR161 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term D 404 - G.S2 E 194 G.S2.03
Van-der-waals C-term D 404 - G.S2 E 194 G.S2.03
Hydrophobic TM5 V 222 5x72 G.H5 L 374 G.H5.26
Hydrophobic C-term M 405 - G.S2 C 196 G.S2.05
Van-der-waals C-term M 405 - G.S2 C 196 G.S2.05
Polar C-term C 397 - G.hfs2 T 190 G.hfs2.06
Hydrophobic C-term C 397 - G.hfs2 T 190 G.hfs2.06
Van-der-waals C-term C 397 - G.hfs2 T 190 G.hfs2.06
Hydrophobic TM6 I 272 6x37 G.H5 L 373 G.H5.25
Polar C-term S 371 - G.H3 E 253 G.H3.04
Hydrophobic TM3 A 128 3x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 M 133 34x51 G.H5 R 360 G.H5.12
Van-der-waals ICL2 M 133 34x51 G.H5 R 360 G.H5.12
Hydrophobic C-term T 403 - G.S2 E 194 G.S2.03
Van-der-waals C-term T 403 - G.S2 E 194 G.S2.03
Polar C-term D 404 - G.S2 C 196 G.S2.05
Van-der-waals C-term D 404 - G.S2 C 196 G.S2.05
Hydrophobic C-term P 348 - G.H3 P 265 G.H3.16
Polar TM6 K 267 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM6 K 267 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 K 267 6x32 G.H5 N 372 G.H5.24
Hydrophobic C-term I 361 - G.H3 P 265 G.H3.16
Van-der-waals C-term I 361 - G.H3 P 265 G.H3.16
Hydrophobic C-term L 368 - G.H3 T 260 G.H3.11
Hydrophobic C-term L 408 - G.h1ha G 67 G.h1ha.01
Van-der-waals C-term L 408 - G.h1ha G 67 G.h1ha.01
Hydrophobic H8 K 329 8x48 G.H5 N 372 G.H5.24
Van-der-waals H8 K 329 8x48 G.H5 N 372 G.H5.24
Aromatic C-term F 395 - H.hbhc Y 122 H.hbhc.01
Hydrophobic C-term F 395 - H.hbhc Y 122 H.hbhc.01
Van-der-waals C-term F 395 - H.hbhc Y 122 H.hbhc.01
Hydrophobic C-term L 408 - G.S2 V 199 G.S2.08
Van-der-waals C-term L 408 - G.S2 V 199 G.S2.08
Hydrophobic ICL2 P 132 34x50 G.H5 L 364 G.H5.16
Polar C-term L 368 - G.H2 R 216 G.H2.04
Hydrophobic C-term L 368 - G.H2 R 216 G.H2.04
Van-der-waals C-term L 368 - G.H2 R 216 G.H2.04
Hydrophobic C-term I 361 - G.H3 L 264 G.H3.15
Hydrophobic C-term I 365 - G.H2 I 220 G.H2.08
Van-der-waals C-term I 365 - G.H2 I 220 G.H2.08
Hydrophobic ICL2 M 133 34x51 G.H5 V 359 G.H5.11
Polar C-term S 401 - G.S2 N 193 G.S2.02
Hydrophobic C-term S 401 - G.S2 N 193 G.S2.02
Van-der-waals C-term S 401 - G.S2 N 193 G.S2.02
Hydrophobic C-term L 407 - G.h1ha G 67 G.h1ha.01
Van-der-waals C-term L 407 - G.h1ha G 67 G.h1ha.01
Polar H8 K 329 8x48 G.H5 D 369 G.H5.21
Ionic H8 K 329 8x48 G.H5 D 369 G.H5.21
Hydrophobic H8 K 329 8x48 G.H5 D 369 G.H5.21
Van-der-waals H8 K 329 8x48 G.H5 D 369 G.H5.21
Hydrophobic ICL2 M 137 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 M 137 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic C-term L 407 - G.S2 S 198 G.S2.07
Van-der-waals C-term L 407 - G.S2 S 198 G.S2.07
Aromatic C-term F 349 - G.H3 W 266 G.H3.17
Hydrophobic C-term F 349 - G.H3 W 266 G.H3.17
Van-der-waals C-term F 349 - G.H3 W 266 G.H3.17
Hydrophobic C-term P 372 - G.H3 A 256 G.H3.07
Van-der-waals C-term P 372 - G.H3 A 256 G.H3.07
Hydrophobic ICL2 M 133 34x51 G.H5 V 363 G.H5.15
Hydrophobic C-term L 368 - G.H3 L 257 G.H3.08
Van-der-waals C-term L 368 - G.H3 L 257 G.H3.08
Hydrophobic ICL2 M 137 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic C-term L 368 - G.H3 I 261 G.H3.12
Hydrophobic TM6 A 268 6x33 G.H5 L 373 G.H5.25
Hydrophobic C-term G 369 - G.H2 R 216 G.H2.04
Hydrophobic C-term S 398 - G.hfs2 M 187 G.hfs2.03
Hydrophobic C-term M 406 - G.H1 R 63 G.H1.09
Van-der-waals C-term M 406 - G.H1 R 63 G.H1.09
Ionic C-term R 364 - G.H3 E 263 G.H3.14
Polar C-term R 364 - G.H3 E 263 G.H3.14
Hydrophobic C-term R 364 - G.H3 E 263 G.H3.14
Van-der-waals C-term R 364 - G.H3 E 263 G.H3.14
Hydrophobic C-term I 361 - G.H3 W 266 G.H3.17
Van-der-waals C-term I 361 - G.H3 W 266 G.H3.17
Hydrophobic C-term L 408 - G.S2 F 197 G.S2.06
Van-der-waals C-term L 408 - G.S2 F 197 G.S2.06
Hydrophobic C-term I 365 - G.H3 W 266 G.H3.17
Hydrophobic C-term R 364 - G.H3 L 264 G.H3.15
Ionic ICL3 E 231 - G.H4 R 310 G.H4.09
Polar ICL3 E 231 - G.H4 R 310 G.H4.09
Van-der-waals ICL3 E 231 - G.H4 R 310 G.H4.09
Hydrophobic C-term L 368 - G.H2 W 219 G.H2.07
Hydrophobic C-term L 358 - G.H2 I 220 G.H2.08
Hydrophobic C-term M 406 - G.S2 Y 195 G.S2.04
Polar C-term L 407 - G.S2 C 196 G.S2.05
Polar TM5 T 226 5x76 G.S6 S 341 G.S6.03
Hydrophobic ICL2 P 132 34x50 G.H5 R 360 G.H5.12
Polar C-term S 401 - G.S2 I 192 G.S2.01
Hydrophobic C-term S 401 - G.S2 I 192 G.S2.01
Van-der-waals C-term S 401 - G.S2 I 192 G.S2.01
Polar TM6 K 267 6x32 G.H5 L 374 G.H5.26
Hydrophobic TM6 K 267 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 267 6x32 G.H5 L 374 G.H5.26
Polar C-term E 409 - G.H1 H 66 G.H1.12
Van-der-waals C-term E 409 - G.H1 H 66 G.H1.12
Hydrophobic C-term S 371 - G.H2 K 213 G.H2.01
Van-der-waals C-term S 371 - G.H2 K 213 G.H2.01
Polar C-term M 406 - G.S2 C 196 G.S2.05
Hydrophobic C-term M 406 - G.S2 C 196 G.S2.05
Van-der-waals C-term M 406 - G.S2 C 196 G.S2.05
Hydrophobic TM5 H 223 5x73 G.H5 L 374 G.H5.26
Van-der-waals TM5 H 223 5x73 G.H5 L 374 G.H5.26
Hydrophobic C-term L 368 - G.h2s4 F 223 G.h2s4.01
Polar C-term L 408 - G.S2 S 198 G.S2.07
Hydrophobic C-term L 408 - G.S2 S 198 G.S2.07
Van-der-waals C-term L 408 - G.S2 S 198 G.S2.07
Van-der-waals C-term D 400 - G.S2 N 193 G.S2.02
Polar C-term G 402 - G.S2 N 193 G.S2.02
Hydrophobic C-term G 402 - G.S2 N 193 G.S2.02
Van-der-waals C-term G 402 - G.S2 N 193 G.S2.02
Hydrophobic C-term T 366 - G.H2 K 217 G.H2.05
Hydrophobic TM5 K 218 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 K 218 5x68 G.H5 L 364 G.H5.16
Hydrophobic C-term I 365 - G.H2 K 217 G.H2.05
Polar TM7 W 327 7x56 G.H5 N 372 G.H5.24
Hydrophobic TM7 W 327 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 W 327 7x56 G.H5 N 372 G.H5.24
Hydrophobic C-term G 369 - G.H2 K 213 G.H2.01
Van-der-waals C-term G 369 - G.H2 K 213 G.H2.01
Hydrophobic ICL2 P 136 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 P 136 34x54 G.hns1 R 40 G.hns1.02
Polar H8 T 330 8x49 G.H5 E 370 G.H5.22
Hydrophobic C-term L 408 - G.H1 H 66 G.H1.12
Van-der-waals C-term L 408 - G.H1 H 66 G.H1.12
Hydrophobic ICL2 M 133 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 M 133 34x51 G.S1 L 43 G.S1.02
Hydrophobic C-term L 408 - G.H1 M 62 G.H1.08
Van-der-waals C-term L 408 - G.H1 M 62 G.H1.08
Hydrophobic C-term F 349 - G.H3 P 265 G.H3.16
Hydrophobic TM3 V 129 3x54 G.H5 I 371 G.H5.23
Hydrophobic ICL2 M 133 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 M 133 34x51 G.H5 F 356 G.H5.08
Hydrophobic TM5 I 211 5x61 G.H5 L 373 G.H5.25
Van-der-waals TM5 I 211 5x61 G.H5 L 373 G.H5.25
Hydrophobic C-term L 368 - G.H3 L 264 G.H3.15
Polar C-term L 407 - G.h1ha A 68 G.h1ha.02
Van-der-waals C-term L 407 - G.h1ha A 68 G.h1ha.02
Hydrophobic ICL2 M 137 34x55 G.S3 T 202 G.S3.01
Hydrophobic TM3 R 125 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 I 371 G.H5.23
Hydrophobic ICL2 P 132 34x50 G.H5 Y 367 G.H5.19
Ionic C-term D 404 - G.H1 R 63 G.H1.09
Polar C-term D 404 - G.H1 R 63 G.H1.09
Polar C-term S 371 - G.s4h3 E 248 G.s4h3.14
Hydrophobic C-term S 371 - G.s4h3 E 248 G.s4h3.14
Van-der-waals C-term S 371 - G.s4h3 E 248 G.s4h3.14
Polar C-term M 406 - G.S2 F 197 G.S2.06
Hydrophobic C-term M 406 - G.S2 F 197 G.S2.06
Van-der-waals C-term M 406 - G.S2 F 197 G.S2.06
Hydrophobic C-term D 404 - G.S2 Y 195 G.S2.04
Van-der-waals C-term D 404 - G.S2 Y 195 G.S2.04
Aromatic ICL2 Y 135 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 Y 135 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 Y 135 34x53 G.H5 Y 367 G.H5.19
Hydrophobic C-term L 408 - G.H5 I 352 G.H5.04
Hydrophobic TM6 T 271 6x36 G.H5 L 373 G.H5.25
Hydrophobic C-term F 395 - G.hfs2 P 188 G.hfs2.04
Polar TM5 V 222 5x72 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 V 222 5x72 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 V 222 5x72 G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL2 P 132 34x50 G.H5 V 363 G.H5.15
Hydrophobic ICL2 M 133 34x51 G.S3 L 204 G.S3.03
Polar TM6 T 271 6x36 G.H5 N 372 G.H5.24
Polar C-term G 402 - G.S2 E 194 G.S2.03
Van-der-waals C-term G 402 - G.S2 E 194 G.S2.03
Hydrophobic H8 N 328 8x47 G.H5 E 370 G.H5.22
Hydrophobic ICL3 V 228 - G.H4 L 313 G.H4.12
Van-der-waals ICL3 V 228 - G.H4 L 313 G.H4.12
Polar C-term G 402 - G.S2 I 192 G.S2.01
Polar TM6 N 264 6x29 G.h4s6 R 335 G.h4s6.17
Hydrophobic ICL2 M 137 34x55 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 M 137 34x55 G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 M 133 34x51 G.S3 T 202 G.S3.01
Hydrophobic TM3 V 129 3x54 G.H5 L 368 G.H5.20
Hydrophobic TM3 V 129 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM5 A 215 5x65 G.H5 L 368 G.H5.20
Polar C-term S 398 - G.hfs2 T 190 G.hfs2.06
Van-der-waals C-term S 398 - G.hfs2 T 190 G.hfs2.06