GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 73.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | A | 215 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Ionic | C-term | R | 354 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Ionic | C-term | E | 347 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Polar | C-term | E | 347 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Van-der-waals | C-term | E | 347 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Polar | C-term | I | 361 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | I | 361 | - | G.H3 | R | 267 | G.H3.16 |
Polar | TM5 | H | 223 | 5x73 | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | TM5 | H | 223 | 5x73 | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | TM3 | A | 128 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Aromatic | TM6 | Y | 261 | 6x26 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | Y | 261 | 6x26 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | Y | 261 | 6x26 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | ICL2 | M | 137 | 34x55 | G.s2s3 | K | 203 | G.s2s3.02 |
Van-der-waals | ICL2 | M | 137 | 34x55 | G.s2s3 | K | 203 | G.s2s3.02 |
Hydrophobic | TM6 | V | 260 | 6x25 | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | ICL3 | V | 228 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Hydrophobic | ICL3 | V | 228 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Van-der-waals | ICL3 | V | 228 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Polar | TM6 | K | 267 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 267 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 267 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Hydrophobic | C-term | F | 349 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Van-der-waals | C-term | F | 349 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Hydrophobic | C-term | I | 365 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | ICL3 | V | 227 | - | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | ICL2 | M | 137 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | M | 137 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | TM5 | G | 225 | 5x75 | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | C-term | L | 368 | - | G.H3 | I | 263 | G.H3.12 |
Hydrophobic | TM6 | I | 272 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | I | 272 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | G | 225 | 5x75 | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | TM5 | G | 225 | 5x75 | G.hgh4 | P | 308 | G.hgh4.11 |
Aromatic | TM3 | R | 125 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 125 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 136 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | P | 136 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | I | 448 | - | G.h1ha | V | 67 | G.h1ha.01 |
Polar | TM3 | V | 129 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 129 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | C | 224 | 5x74 | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | TM5 | C | 224 | 5x74 | G.H4 | L | 333 | G.H4.16 |
Polar | C-term | S | 360 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | S | 360 | - | G.H3 | R | 267 | G.H3.16 |
Polar | TM6 | Y | 261 | 6x26 | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | TM6 | Y | 261 | 6x26 | G.S6 | C | 346 | G.S6.01 |
Aromatic | ICL2 | Y | 135 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | Y | 135 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL3 | V | 230 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 132 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | L | 368 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Polar | TM5 | C | 224 | 5x74 | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | TM5 | C | 224 | 5x74 | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | TM5 | C | 224 | 5x74 | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | C-term | I | 361 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | I | 361 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | C-term | L | 368 | - | G.H2 | R | 218 | G.H2.04 |
Van-der-waals | C-term | L | 368 | - | G.H2 | R | 218 | G.H2.04 |
Polar | C-term | H | 450 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | H | 450 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | H | 450 | - | G.H1 | R | 63 | G.H1.09 |
Ionic | TM5 | K | 218 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 218 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 218 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 218 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | C-term | L | 368 | - | G.H3 | S | 262 | G.H3.11 |
Van-der-waals | C-term | L | 368 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM5 | I | 211 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | I | 365 | - | G.H2 | I | 222 | G.H2.08 |
Polar | H8 | K | 329 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | H8 | K | 329 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM7 | W | 327 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | I | 361 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Polar | TM3 | A | 128 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 128 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 128 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | V | 134 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM5 | K | 218 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Ionic | H8 | K | 329 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | K | 329 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | K | 329 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | K | 329 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | A | 219 | 5x69 | G.H5 | L | 381 | G.H5.26 |
Ionic | H8 | R | 332 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 332 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | V | 227 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | ICL3 | V | 228 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | ICL3 | V | 227 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL2 | M | 137 | 34x55 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM6 | T | 271 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | S | 362 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | S | 362 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | TM5 | V | 214 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | C-term | S | 360 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | S | 360 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | C-term | I | 365 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Van-der-waals | C-term | I | 365 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | ICL2 | P | 136 | 34x54 | G.hns1 | A | 41 | G.hns1.03 |
Polar | TM5 | H | 223 | 5x73 | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | TM5 | H | 223 | 5x73 | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | TM5 | H | 223 | 5x73 | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM6 | A | 268 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | A | 268 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 268 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | P | 348 | - | G.H3 | W | 268 | G.H3.17 |
Polar | C-term | D | 404 | - | H.HA | Q | 77 | H.HA.06 |
Van-der-waals | C-term | D | 404 | - | H.HA | Q | 77 | H.HA.06 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Polar | TM5 | K | 218 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | K | 218 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | K | 218 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | R | 357 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | C-term | R | 357 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Polar | ICL2 | M | 133 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | C-term | R | 364 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | A | 263 | 6x28 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | A | 263 | 6x28 | G.H5 | L | 381 | G.H5.26 |
Polar | C-term | R | 354 | - | G.hns1 | Y | 39 | G.hns1.01 |
Aromatic | C-term | R | 354 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | C-term | R | 354 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | R | 354 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | TM6 | K | 267 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM5 | V | 214 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Aromatic | TM6 | Y | 261 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Ionic | TM6 | K | 267 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Polar | TM6 | K | 267 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | K | 267 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 267 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Polar | TM5 | K | 218 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | K | 218 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | K | 218 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM5 | T | 226 | 5x76 | G.hgh4 | T | 306 | G.hgh4.09 |
Van-der-waals | TM5 | T | 226 | 5x76 | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | TM5 | C | 224 | 5x74 | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | C-term | L | 368 | - | G.H3 | L | 259 | G.H3.08 |
Polar | H8 | T | 330 | 8x49 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | P | 132 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | C-term | L | 368 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | I | 361 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | C-term | I | 361 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | I | 361 | - | G.H3 | W | 268 | G.H3.17 |
Polar | TM6 | T | 271 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | T | 271 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 271 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | C | 224 | 5x74 | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | C-term | S | 398 | - | H.hbhc | T | 125 | H.hbhc.02 |
Van-der-waals | C-term | S | 398 | - | H.hbhc | T | 125 | H.hbhc.02 |
Polar | TM5 | G | 225 | 5x75 | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | TM5 | G | 225 | 5x75 | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | TM5 | G | 225 | 5x75 | G.H4 | D | 330 | G.H4.13 |
Polar | TM2 | S | 62 | 2x39 | G.H5 | Y | 378 | G.H5.23 |