G13 - GPR162 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 66.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 18.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term F 482 - G.H3 N 270 G.H3.07
Hydrophobic C-term F 508 - H.hdhe Q 169 H.hdhe.02
Van-der-waals C-term F 508 - H.hdhe Q 169 H.hdhe.02
Hydrophobic C-term L 479 - G.H3 T 274 G.H3.11
Van-der-waals C-term L 479 - G.H3 T 274 G.H3.11
Ionic ICL3 D 258 - G.H4 R 331 G.H4.16
Polar ICL3 D 258 - G.H4 R 331 G.H4.16
Hydrophobic ICL3 D 258 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 D 258 - G.H4 R 331 G.H4.16
Polar ICL3 S 256 - G.S6 H 344 G.S6.03
Hydrophobic ICL3 S 256 - G.S6 H 344 G.S6.03
Van-der-waals ICL3 S 256 - G.S6 H 344 G.S6.03
Hydrophobic C-term L 479 - G.H3 N 278 G.H3.15
Van-der-waals C-term L 479 - G.H3 N 278 G.H3.15
Polar C-term E 484 - G.H2 K 231 G.H2.05
Hydrophobic C-term E 484 - G.H2 K 231 G.H2.05
Van-der-waals C-term E 484 - G.H2 K 231 G.H2.05
Hydrophobic TM3 M 118 3x53 G.H5 L 371 G.H5.20
Hydrophobic H8 R 329 8x49 G.H5 M 375 G.H5.24
Van-der-waals H8 R 329 8x49 G.H5 M 375 G.H5.24
Hydrophobic C-term I 509 - G.s3h2 Q 226 G.s3h2.03
Ionic C-term E 511 - H.hbhc R 128 H.hbhc.01
Polar C-term E 511 - H.hbhc R 128 H.hbhc.01
Van-der-waals C-term E 511 - H.hbhc R 128 H.hbhc.01
Hydrophobic C-term I 505 - G.s4h3 R 260 G.s4h3.12
Hydrophobic ICL2 L 127 34x55 G.S3 V 216 G.S3.01
Hydrophobic ICL3 S 255 - G.S6 H 344 G.S6.03
Van-der-waals ICL3 S 255 - G.S6 H 344 G.S6.03
Hydrophobic ICL2 V 123 34x51 G.H5 I 366 G.H5.15
Hydrophobic ICL2 Y 125 34x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 M 118 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 M 118 3x53 G.H5 N 370 G.H5.19
Polar H8 R 329 8x49 G.H5 Q 373 G.H5.22
Van-der-waals H8 R 329 8x49 G.H5 Q 373 G.H5.22
Hydrophobic C-term L 476 - G.H2 F 234 G.H2.08
Hydrophobic C-term I 505 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term I 505 - G.s4h3 M 257 G.s4h3.09
Polar C-term P 513 - H.HA K 105 H.HA.28
Van-der-waals C-term P 513 - H.HA K 105 H.HA.28
Ionic C-term E 504 - G.s4h3 R 260 G.s4h3.12
Polar C-term E 504 - G.s4h3 R 260 G.s4h3.12
Hydrophobic C-term E 504 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term E 504 - G.s4h3 R 260 G.s4h3.12
Hydrophobic ICL2 P 122 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 P 122 34x50 G.H5 K 363 G.H5.12
Polar C-term G 475 - G.H3 N 278 G.H3.15
Van-der-waals C-term G 475 - G.H3 N 278 G.H3.15
Polar TM2 K 46 2x38 G.H5 Q 373 G.H5.22
Hydrophobic TM2 K 46 2x38 G.H5 Q 373 G.H5.22
Van-der-waals TM2 K 46 2x38 G.H5 Q 373 G.H5.22
Hydrophobic TM3 V 119 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM6 T 265 6x28 G.H5 M 375 G.H5.24
Van-der-waals TM6 T 265 6x28 G.H5 M 375 G.H5.24
Polar C-term I 505 - G.s3h2 Q 226 G.s3h2.03
Hydrophobic C-term P 515 - H.HA K 105 H.HA.28
Van-der-waals C-term P 515 - H.HA K 105 H.HA.28
Hydrophobic ICL2 R 126 34x54 G.H5 I 366 G.H5.15
Van-der-waals ICL2 R 126 34x54 G.H5 I 366 G.H5.15
Hydrophobic ICL2 V 123 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 V 123 34x51 G.S3 V 216 G.S3.01
Hydrophobic C-term L 479 - G.H3 F 281 G.H3.18
Hydrophobic TM6 Q 268 6x31 G.H5 M 375 G.H5.24
Van-der-waals TM6 Q 268 6x31 G.H5 M 375 G.H5.24
Hydrophobic ICL2 R 126 34x54 G.H5 N 370 G.H5.19
Polar C-term A 471 - G.H3 R 279 G.H3.16
Hydrophobic C-term I 509 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term I 509 - G.s4h3 M 257 G.s4h3.09
Polar TM3 R 120 3x55 G.H5 K 363 G.H5.12
Van-der-waals TM3 R 120 3x55 G.H5 K 363 G.H5.12
Polar ICL3 R 254 - G.HG T 293 G.HG.01
Hydrophobic ICL3 R 254 - G.HG T 293 G.HG.01
Van-der-waals ICL3 R 254 - G.HG T 293 G.HG.01
Polar C-term L 514 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term L 514 - G.s4h3 R 260 G.s4h3.12
Hydrophobic ICL3 R 254 - G.H4 Q 323 G.H4.08
Hydrophobic ICL2 V 123 34x51 G.H5 K 363 G.H5.12
Van-der-waals ICL3 A 216 - G.H5 R 360 G.H5.09
Polar ICL2 R 126 34x54 G.h2s4 T 241 G.h2s4.05
Hydrophobic ICL2 R 126 34x54 G.h2s4 T 241 G.h2s4.05
Polar TM1 K 41 1x60 G.H5 Q 377 G.H5.26
Hydrophobic TM1 K 41 1x60 G.H5 Q 377 G.H5.26
Van-der-waals TM1 K 41 1x60 G.H5 Q 377 G.H5.26
Hydrophobic C-term F 508 - H.HA V 98 H.HA.21
Van-der-waals C-term F 508 - H.HA V 98 H.HA.21
Hydrophobic ICL3 L 257 - G.S6 Y 343 G.S6.02
Van-der-waals ICL3 L 257 - G.S6 Y 343 G.S6.02
Hydrophobic ICL3 R 254 - G.S6 H 345 G.S6.04
Van-der-waals ICL3 R 254 - G.S6 H 345 G.S6.04
Hydrophobic C-term L 483 - G.h2s4 F 237 G.h2s4.01
Hydrophobic ICL3 D 258 - G.h4s6 P 341 G.h4s6.20
Van-der-waals ICL3 D 258 - G.h4s6 P 341 G.h4s6.20
Hydrophobic C-term L 479 - G.h2s4 F 237 G.h2s4.01
Van-der-waals C-term L 479 - G.h2s4 F 237 G.h2s4.01
Hydrophobic C-term F 482 - G.H3 T 274 G.H3.11
Van-der-waals C-term F 482 - G.H3 T 274 G.H3.11
Hydrophobic C-term L 479 - G.H2 F 234 G.H2.08
Van-der-waals C-term L 479 - G.H2 F 234 G.H2.08
Hydrophobic C-term I 509 - G.hfs2 P 202 G.hfs2.04
Van-der-waals C-term I 509 - G.hfs2 P 202 G.hfs2.04
Polar ICL3 D 258 - G.S6 L 342 G.S6.01
Hydrophobic ICL3 D 258 - G.S6 L 342 G.S6.01
Van-der-waals ICL3 D 258 - G.S6 L 342 G.S6.01
Hydrophobic C-term E 511 - H.HB T 127 H.HB.14
Hydrophobic C-term P 513 - H.HA D 101 H.HA.24
Van-der-waals C-term P 513 - H.HA D 101 H.HA.24
Hydrophobic C-term L 483 - G.H2 R 230 G.H2.04
Van-der-waals C-term L 483 - G.H2 R 230 G.H2.04
Hydrophobic TM6 V 269 6x32 G.H5 L 374 G.H5.23
Van-der-waals TM6 V 269 6x32 G.H5 L 374 G.H5.23
Polar ICL2 P 122 34x50 G.H5 N 370 G.H5.19
Van-der-waals ICL2 P 122 34x50 G.H5 N 370 G.H5.19
Polar ICL3 R 254 - G.S6 F 346 G.S6.05
Hydrophobic ICL3 R 254 - G.S6 F 346 G.S6.05
Van-der-waals ICL3 R 254 - G.S6 F 346 G.S6.05
Hydrophobic C-term T 512 - H.HA R 97 H.HA.20
Van-der-waals C-term T 512 - H.HA R 97 H.HA.20
Hydrophobic ICL2 P 122 34x50 G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 122 34x50 G.H5 I 366 G.H5.15
Hydrophobic TM6 T 265 6x28 G.H5 L 371 G.H5.20
Ionic ICL2 R 126 34x54 G.H5 D 369 G.H5.18
Polar ICL2 R 126 34x54 G.H5 D 369 G.H5.18
Van-der-waals ICL2 R 126 34x54 G.H5 D 369 G.H5.18
Hydrophobic C-term R 447 - G.HN L 5 G.HN.05
Polar C-term I 509 - H.HA K 94 H.HA.17
Hydrophobic C-term I 509 - H.HA K 94 H.HA.17
Van-der-waals C-term I 509 - H.HA K 94 H.HA.17
Van-der-waals ICL2 R 126 34x54 G.hns1 K 46 G.hns1.02
Polar C-term S 516 - H.HD E 167 H.HD.12
Hydrophobic ICL2 V 123 34x51 G.S1 V 49 G.S1.02
Hydrophobic TM3 M 118 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 M 118 3x53 G.H5 L 374 G.H5.23
Hydrophobic C-term I 505 - G.s4h3 E 258 G.s4h3.10
Van-der-waals C-term I 505 - G.s4h3 E 258 G.s4h3.10
Hydrophobic TM5 R 209 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 R 209 5x68 G.H5 L 367 G.H5.16
Hydrophobic C-term L 476 - G.H3 V 280 G.H3.17
Hydrophobic TM3 R 115 3x50 G.H5 L 371 G.H5.20
Van-der-waals TM3 R 115 3x50 G.H5 L 371 G.H5.20
Ionic C-term D 510 - H.HA K 94 H.HA.17
Polar C-term D 510 - H.HA K 94 H.HA.17
Hydrophobic C-term D 510 - H.HA K 94 H.HA.17
Van-der-waals C-term D 510 - H.HA K 94 H.HA.17
Hydrophobic ICL2 P 122 34x50 G.H5 L 367 G.H5.16
Van-der-waals ICL2 P 122 34x50 G.H5 L 367 G.H5.16
Hydrophobic C-term F 508 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term F 508 - G.s4h3 M 257 G.s4h3.09
Polar H8 R 329 8x49 G.H5 L 374 G.H5.23
Hydrophobic H8 R 329 8x49 G.H5 L 374 G.H5.23
Van-der-waals H8 R 329 8x49 G.H5 L 374 G.H5.23
Hydrophobic ICL3 G 259 - G.h4s6 P 341 G.h4s6.20
Polar ICL1 Q 42 12x48 G.H5 Q 377 G.H5.26
Hydrophobic ICL1 Q 42 12x48 G.H5 Q 377 G.H5.26
Van-der-waals ICL1 Q 42 12x48 G.H5 Q 377 G.H5.26
Hydrophobic C-term T 512 - H.HB M 123 H.HB.10
Aromatic C-term R 480 - G.H2 F 234 G.H2.08
Hydrophobic C-term R 480 - G.H2 F 234 G.H2.08
Van-der-waals C-term R 480 - G.H2 F 234 G.H2.08
Hydrophobic TM2 K 46 2x38 G.H5 L 374 G.H5.23
Hydrophobic TM6 V 269 6x32 G.H5 M 375 G.H5.24
Van-der-waals TM6 V 269 6x32 G.H5 M 375 G.H5.24
Hydrophobic C-term A 448 - G.HN L 5 G.HN.05
Van-der-waals C-term A 448 - G.HN L 5 G.HN.05
Hydrophobic ICL2 L 127 34x55 G.S3 P 217 G.S3.02
Hydrophobic ICL3 S 255 - G.S6 H 345 G.S6.04
Van-der-waals ICL3 S 255 - G.S6 H 345 G.S6.04
Hydrophobic C-term F 500 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term F 500 - G.s4h3 R 260 G.s4h3.12
Hydrophobic TM2 L 48 2x40 G.H5 L 374 G.H5.23
Hydrophobic C-term D 510 - H.HB T 127 H.HB.14
Hydrophobic TM6 S 266 6x29 G.H5 L 371 G.H5.20
Van-der-waals TM6 S 266 6x29 G.H5 L 371 G.H5.20
Polar C-term L 483 - G.H2 K 231 G.H2.05
Hydrophobic C-term L 483 - G.H2 K 231 G.H2.05
Van-der-waals C-term L 483 - G.H2 K 231 G.H2.05
Hydrophobic C-term F 500 - G.s4h3 D 259 G.s4h3.11
Van-der-waals C-term F 500 - G.s4h3 D 259 G.s4h3.11
Hydrophobic C-term L 483 - G.H2 W 233 G.H2.07
Polar TM6 S 262 6x25 G.H5 H 368 G.H5.17
Hydrophobic TM6 S 262 6x25 G.H5 H 368 G.H5.17
Van-der-waals TM6 S 262 6x25 G.H5 H 368 G.H5.17
Hydrophobic C-term P 513 - H.HA V 98 H.HA.21
Polar H8 R 329 8x49 G.H5 Q 377 G.H5.26
Hydrophobic H8 R 329 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 329 8x49 G.H5 Q 377 G.H5.26
Polar C-term D 510 - H.hbhc G 135 H.hbhc.08
Hydrophobic C-term V 406 - G.h1ha Q 74 G.h1ha.02
Van-der-waals C-term V 406 - G.h1ha Q 74 G.h1ha.02
Ionic ICL3 R 254 - G.HG E 297 G.HG.05
Polar ICL3 R 254 - G.HG E 297 G.HG.05
Hydrophobic ICL3 R 254 - G.HG E 297 G.HG.05
Van-der-waals ICL3 R 254 - G.HG E 297 G.HG.05
Polar ICL2 L 127 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 127 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 L 127 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 127 34x55 G.S1 V 49 G.S1.02
Hydrophobic C-term L 483 - G.H2 F 234 G.H2.08
Van-der-waals C-term L 483 - G.H2 F 234 G.H2.08
Ionic C-term D 510 - G.hfs2 K 204 G.hfs2.06
Hydrophobic C-term D 510 - H.hbhc A 133 H.hbhc.06