G14 - GPR171 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 116 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 L 116 3x54 G.H5 L 354 G.H5.25
Polar ICL1 H 46 - G.h3s5 N 262 G.h3s5.02
Hydrophobic ICL1 H 46 - G.h3s5 N 262 G.h3s5.02
Van-der-waals ICL1 H 46 - G.h3s5 N 262 G.h3s5.02
Ionic TM1 K 42 1x60 G.h4s6 E 317 G.h4s6.12
Hydrophobic TM1 K 42 1x60 G.h4s6 E 317 G.h4s6.12
Hydrophobic TM6 N 217 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 N 217 6x29 G.H5 L 349 G.H5.20
Polar TM3 R 112 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 F 352 G.H5.23
Polar TM3 H 118 3x56 G.hns1 R 34 G.hns1.03
Hydrophobic TM3 H 118 3x56 G.hns1 R 34 G.hns1.03
Van-der-waals TM3 H 118 3x56 G.hns1 R 34 G.hns1.03
Polar TM3 T 117 3x55 G.hns1 R 33 G.hns1.02
Van-der-waals TM3 T 117 3x55 G.hns1 R 33 G.hns1.02
Hydrophobic TM6 N 217 6x29 G.H5 L 354 G.H5.25
Van-der-waals TM6 N 217 6x29 G.H5 L 354 G.H5.25
Ionic TM5 R 204 5x63 G.HN D 28 G.HN.50
Polar TM5 R 204 5x63 G.HN D 28 G.HN.50
Van-der-waals TM5 R 204 5x63 G.HN D 28 G.HN.50
Polar ICL2 C 120 34x51 G.S1 E 35 G.S1.01
Hydrophobic ICL2 C 120 34x51 G.S1 E 35 G.S1.01
Van-der-waals ICL2 C 120 34x51 G.S1 E 35 G.S1.01
Hydrophobic TM3 R 112 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 112 3x50 G.H5 L 354 G.H5.25
Polar H8 S 289 8x47 G.H5 N 353 G.H5.24
Hydrophobic H8 S 289 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 S 289 8x47 G.H5 N 353 G.H5.24
Polar ICL2 C 120 34x51 G.S3 R 198 G.S3.04
Hydrophobic ICL2 C 120 34x51 G.S3 R 198 G.S3.04
Van-der-waals ICL2 C 120 34x51 G.S3 R 198 G.S3.04
Ionic TM2 R 47 2x37 G.H5 E 351 G.H5.22
Polar TM2 R 47 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM2 R 47 2x37 G.H5 E 351 G.H5.22
Van-der-waals TM2 R 47 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM6 N 217 6x29 G.H5 V 355 G.H5.26
Van-der-waals TM6 N 217 6x29 G.H5 V 355 G.H5.26
Hydrophobic TM6 N 214 6x26 G.H5 L 349 G.H5.20
Van-der-waals TM6 N 214 6x26 G.H5 L 349 G.H5.20
Hydrophobic TM3 T 117 3x55 G.hns1 A 32 G.hns1.01
Van-der-waals TM3 T 117 3x55 G.hns1 A 32 G.hns1.01
Polar ICL2 Y 123 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL2 Y 123 34x54 G.h2s4 T 220 G.h2s4.05
Van-der-waals ICL2 Y 123 34x54 G.h2s4 T 220 G.h2s4.05
Polar TM7 L 288 7x56 G.H5 N 353 G.H5.24
Hydrophobic TM7 L 288 7x56 G.H5 N 353 G.H5.24
Van-der-waals TM7 L 288 7x56 G.H5 N 353 G.H5.24
Polar H8 K 290 8x48 G.H5 N 353 G.H5.24
Hydrophobic H8 K 290 8x48 G.H5 N 353 G.H5.24
Van-der-waals H8 K 290 8x48 G.H5 N 353 G.H5.24
Polar ICL2 Q 126 34x57 G.hns1 R 34 G.hns1.03
Polar TM3 Q 115 3x53 G.hns1 R 34 G.hns1.03
Hydrophobic TM3 Q 115 3x53 G.hns1 R 34 G.hns1.03
Van-der-waals TM3 Q 115 3x53 G.hns1 R 34 G.hns1.03
Van-der-waals TM2 R 47 2x37 G.h3s5 N 262 G.h3s5.02
Polar ICL3 N 212 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL3 N 212 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL3 N 212 - G.s2s3 N 194 G.s2s3.02
Polar TM3 R 112 3x50 G.H5 N 353 G.H5.24
Hydrophobic TM3 R 112 3x50 G.H5 N 353 G.H5.24
Van-der-waals TM3 R 112 3x50 G.H5 N 353 G.H5.24
Polar TM4 E 127 4x38 G.h2s4 S 218 G.h2s4.03
Van-der-waals TM4 E 127 4x38 G.h2s4 S 218 G.h2s4.03
Polar TM3 T 117 3x55 G.hns1 R 34 G.hns1.03
Hydrophobic TM3 H 118 3x56 G.hns1 R 33 G.hns1.02
Polar TM6 K 220 6x32 G.H5 V 355 G.H5.26
Hydrophobic TM6 K 220 6x32 G.H5 V 355 G.H5.26
Van-der-waals TM6 K 220 6x32 G.H5 V 355 G.H5.26
Hydrophobic ICL1 H 46 - G.h3s5 L 261 G.h3s5.01
Van-der-waals ICL1 H 46 - G.h3s5 L 261 G.h3s5.01
Hydrophobic TM3 H 118 3x56 G.H5 L 349 G.H5.20
Hydrophobic TM3 H 118 3x56 G.S3 I 195 G.S3.01
Van-der-waals TM3 H 118 3x56 G.S3 I 195 G.S3.01
Hydrophobic TM6 A 221 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 221 6x33 G.H5 L 354 G.H5.25
Polar ICL2 S 119 34x50 G.HN D 31 G.HN.53
Van-der-waals ICL2 S 119 34x50 G.HN D 31 G.HN.53
Polar TM5 R 208 5x67 G.HN L 25 G.HN.47
Hydrophobic TM5 R 208 5x67 G.HN L 25 G.HN.47
Polar ICL2 S 119 34x50 G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 S 119 34x50 G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 S 119 34x50 G.hns1 R 33 G.hns1.02
Ionic TM5 R 208 5x67 G.HN D 28 G.HN.50
Polar TM5 R 208 5x67 G.HN D 28 G.HN.50
Hydrophobic TM5 R 208 5x67 G.HN D 28 G.HN.50
Van-der-waals TM5 R 208 5x67 G.HN D 28 G.HN.50
Polar ICL2 Y 123 34x54 G.h2s4 S 218 G.h2s4.03
Hydrophobic ICL2 Y 123 34x54 G.h2s4 S 218 G.h2s4.03
Van-der-waals ICL2 Y 123 34x54 G.h2s4 S 218 G.h2s4.03
Hydrophobic TM6 K 220 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 220 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM3 Q 115 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 Q 115 3x53 G.H5 F 352 G.H5.23
Polar TM3 H 118 3x56 G.S1 E 35 G.S1.01
Van-der-waals TM3 H 118 3x56 G.S1 E 35 G.S1.01
Polar TM6 K 220 6x32 G.H5 N 353 G.H5.24
Hydrophobic TM6 K 220 6x32 G.H5 N 353 G.H5.24
Van-der-waals TM6 K 220 6x32 G.H5 N 353 G.H5.24
Polar TM6 N 224 6x36 G.H5 N 353 G.H5.24
Hydrophobic ICL2 S 119 34x50 G.hns1 R 34 G.hns1.03
Hydrophobic TM3 Q 115 3x53 G.H5 L 354 G.H5.25
Polar ICL2 Y 123 34x54 G.h2s4 V 219 G.h2s4.04
Hydrophobic ICL2 Y 123 34x54 G.h2s4 V 219 G.h2s4.04
Van-der-waals ICL2 Y 123 34x54 G.h2s4 V 219 G.h2s4.04
Polar TM7 H 287 7x55 G.H5 N 353 G.H5.24
Hydrophobic ICL2 S 119 34x50 G.S1 E 35 G.S1.01