Go - GPR171 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 124 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 124 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 124 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM3 L 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 116 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 V 49 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 49 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM4 G 129 4x40 G.HN I 28 G.HN.52
Van-der-waals TM4 G 129 4x40 G.HN I 28 G.HN.52
Polar TM6 N 214 6x26 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 Y 123 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 Y 123 34x54 G.S3 L 195 G.S3.01
Polar TM3 R 112 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM4 E 127 4x38 G.HN I 28 G.HN.52
Van-der-waals TM4 E 127 4x38 G.HN I 28 G.HN.52
Ionic H8 K 290 8x48 G.h3s5 D 262 G.h3s5.02
Polar H8 K 290 8x48 G.h3s5 D 262 G.h3s5.02
Hydrophobic H8 K 290 8x48 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 K 290 8x48 G.h3s5 D 262 G.h3s5.02
Polar H8 K 290 8x48 G.H5 R 349 G.H5.21
Hydrophobic H8 K 290 8x48 G.H5 R 349 G.H5.21
Van-der-waals H8 K 290 8x48 G.H5 R 349 G.H5.21
Hydrophobic TM2 R 47 2x37 G.H5 G 350 G.H5.22
Van-der-waals TM2 R 47 2x37 G.H5 G 350 G.H5.22
Hydrophobic TM4 P 128 4x39 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 P 128 4x39 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 C 120 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 C 120 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic H8 K 290 8x48 G.h4s6 N 316 G.h4s6.10
Hydrophobic ICL2 Y 123 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Y 123 34x54 G.H5 I 343 G.H5.15
Polar TM3 R 112 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 H 118 3x56 G.H5 I 344 G.H5.16
Van-der-waals TM3 H 118 3x56 G.H5 I 344 G.H5.16
Polar H8 R 293 8x51 G.H5 G 352 G.H5.24
Hydrophobic H8 R 293 8x51 G.H5 G 352 G.H5.24
Van-der-waals H8 R 293 8x51 G.H5 G 352 G.H5.24
Polar TM3 Q 115 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM3 Q 115 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 Q 115 3x53 G.H5 L 348 G.H5.20
Ionic TM3 H 118 3x56 G.H5 D 341 G.H5.13
Polar TM3 H 118 3x56 G.H5 D 341 G.H5.13
Hydrophobic TM3 H 118 3x56 G.H5 D 341 G.H5.13
Van-der-waals TM3 H 118 3x56 G.H5 D 341 G.H5.13
Hydrophobic TM3 H 118 3x56 G.H5 T 340 G.H5.12
Polar ICL2 Y 123 34x54 G.H5 I 344 G.H5.16
Polar ICL2 Q 126 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Q 126 34x57 G.H5 N 347 G.H5.19
Polar TM3 Q 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 Q 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 Q 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 116 3x54 G.H5 L 353 G.H5.25
Polar ICL2 Y 123 34x54 G.H5 T 340 G.H5.12
Hydrophobic ICL2 Y 123 34x54 G.H5 T 340 G.H5.12
Van-der-waals ICL2 Y 123 34x54 G.H5 T 340 G.H5.12
Polar H8 R 293 8x51 G.H5 Y 354 G.H5.26
Hydrophobic H8 R 293 8x51 G.H5 Y 354 G.H5.26
Van-der-waals H8 R 293 8x51 G.H5 Y 354 G.H5.26
Ionic TM4 E 127 4x38 G.hns1 K 32 G.hns1.03
Polar TM4 E 127 4x38 G.hns1 K 32 G.hns1.03
Hydrophobic TM4 E 127 4x38 G.hns1 K 32 G.hns1.03
Van-der-waals TM4 E 127 4x38 G.hns1 K 32 G.hns1.03
Hydrophobic TM2 R 47 2x37 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 112 3x50 G.H5 L 353 G.H5.25
Ionic C-term E 316 - G.h4s6 R 313 G.h4s6.03
Polar TM7 L 288 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 L 288 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 288 7x56 G.H5 G 352 G.H5.24
Polar TM7 L 288 7x56 G.H5 C 351 G.H5.23
Hydrophobic TM7 L 288 7x56 G.H5 C 351 G.H5.23
Van-der-waals TM7 L 288 7x56 G.H5 C 351 G.H5.23
Hydrophobic TM4 E 127 4x38 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 E 127 4x38 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 116 3x54 G.H5 I 344 G.H5.16
Polar TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 Q 115 3x53 G.H5 I 344 G.H5.16
Van-der-waals TM3 Q 115 3x53 G.H5 I 344 G.H5.16
Polar ICL2 C 120 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM6 I 225 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 225 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 S 289 8x47 G.H5 G 350 G.H5.22
Hydrophobic TM7 L 288 7x56 G.H5 G 350 G.H5.22
Van-der-waals TM7 L 288 7x56 G.H5 G 350 G.H5.22
Polar TM7 H 287 7x55 G.H5 G 352 G.H5.24
Hydrophobic TM7 H 287 7x55 G.H5 G 352 G.H5.24
Van-der-waals TM7 H 287 7x55 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 124 34x55 G.hns1 K 32 G.hns1.03
Polar TM2 R 47 2x37 G.H5 N 346 G.H5.18
Hydrophobic TM2 R 47 2x37 G.H5 N 346 G.H5.18
Van-der-waals TM2 R 47 2x37 G.H5 N 346 G.H5.18