Gt2 - GPR171 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 82.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 116 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL1 N 45 - G.h3s5 A 261 G.h3s5.02
Van-der-waals ICL1 N 45 - G.h3s5 A 261 G.h3s5.02
Hydrophobic TM2 V 49 2x39 G.H5 C 351 G.H5.23
Polar ICL2 S 119 34x50 G.H5 N 347 G.H5.19
Polar ICL2 C 120 34x51 G.S1 T 33 G.S1.01
Hydrophobic ICL2 C 120 34x51 G.S1 T 33 G.S1.01
Van-der-waals ICL2 C 120 34x51 G.S1 T 33 G.S1.01
Polar ICL3 N 212 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 N 212 - G.H5 D 341 G.H5.13
Polar ICL1 N 45 - G.h3s5 A 260 G.h3s5.01
Hydrophobic ICL1 N 45 - G.h3s5 A 260 G.h3s5.01
Van-der-waals ICL1 N 45 - G.h3s5 A 260 G.h3s5.01
Polar ICL2 K 121 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 121 34x52 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 K 121 34x52 G.hns1 K 32 G.hns1.03
Ionic ICL2 R 124 34x55 G.hns1 E 30 G.hns1.01
Polar ICL2 R 124 34x55 G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 R 124 34x55 G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 R 124 34x55 G.hns1 E 30 G.hns1.01
Polar TM3 R 112 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 C 351 G.H5.23
Ionic TM2 R 47 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 47 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 47 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 47 2x37 G.H5 D 350 G.H5.22
Polar TM3 D 111 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 111 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 111 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 H 118 3x56 G.H5 N 347 G.H5.19
Polar ICL2 C 120 34x51 G.S1 K 35 G.S1.03
Hydrophobic ICL2 C 120 34x51 G.S1 K 35 G.S1.03
Van-der-waals ICL2 C 120 34x51 G.S1 K 35 G.S1.03
Van-der-waals TM6 N 217 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 N 217 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 217 6x29 G.H5 F 354 G.H5.26
Polar TM6 N 224 6x36 G.H5 L 353 G.H5.25
Polar ICL2 I 122 34x53 G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 I 122 34x53 G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 I 122 34x53 G.hns1 E 30 G.hns1.01
Polar TM3 L 116 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 116 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 H 118 3x56 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 H 118 3x56 G.hns1 K 32 G.hns1.03
Polar ICL2 S 119 34x50 G.S1 T 33 G.S1.01
Hydrophobic ICL2 S 119 34x50 G.S1 T 33 G.S1.01
Van-der-waals ICL2 S 119 34x50 G.S1 T 33 G.S1.01
Polar ICL2 I 122 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 I 122 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 I 122 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 112 3x50 G.H5 G 352 G.H5.24
Polar TM3 H 118 3x56 G.H5 I 344 G.H5.16
Hydrophobic TM3 H 118 3x56 G.H5 I 344 G.H5.16
Van-der-waals TM3 H 118 3x56 G.H5 I 344 G.H5.16
Ionic ICL2 K 121 34x52 G.HN D 28 G.HN.52
Polar ICL2 K 121 34x52 G.HN D 28 G.HN.52
Hydrophobic ICL2 K 121 34x52 G.HN D 28 G.HN.52
Van-der-waals ICL2 K 121 34x52 G.HN D 28 G.HN.52
Hydrophobic TM3 H 118 3x56 G.H5 L 348 G.H5.20
Van-der-waals TM3 H 118 3x56 G.H5 L 348 G.H5.20
Polar TM2 R 47 2x37 G.h3s5 A 261 G.h3s5.02
Hydrophobic TM3 H 118 3x56 G.S3 L 194 G.S3.01
Van-der-waals TM3 H 118 3x56 G.S3 L 194 G.S3.01
Hydrophobic TM3 Q 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 Q 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 C 120 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 C 120 34x51 G.S1 V 34 G.S1.02
Polar ICL2 K 121 34x52 G.S1 T 33 G.S1.01
Hydrophobic ICL2 K 121 34x52 G.S1 T 33 G.S1.01
Van-der-waals ICL2 K 121 34x52 G.S1 T 33 G.S1.01
Ionic H8 K 290 8x48 G.H5 E 346 G.H5.18
Hydrophobic TM3 L 116 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 116 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 S 119 34x50 G.hns1 K 32 G.hns1.03
Polar TM3 Q 115 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 Q 115 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 Q 115 3x53 G.H5 D 350 G.H5.22
Polar H8 R 293 8x51 G.H5 F 354 G.H5.26
Hydrophobic H8 R 293 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 R 293 8x51 G.H5 F 354 G.H5.26
Van-der-waals ICL2 C 120 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 K 121 34x52 G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 K 121 34x52 G.hns1 E 30 G.hns1.01
Polar ICL2 K 121 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 121 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 121 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 121 34x52 G.HN K 29 G.HN.53
Van-der-waals ICL2 K 121 34x52 G.HN K 29 G.HN.53
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Ionic TM5 R 208 5x67 G.s2s3 D 193 G.s2s3.02
Polar TM5 R 208 5x67 G.s2s3 D 193 G.s2s3.02
Van-der-waals TM5 R 208 5x67 G.s2s3 D 193 G.s2s3.02
Polar TM6 N 214 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 N 214 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM2 V 49 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 49 2x39 G.H5 D 350 G.H5.22
Polar ICL2 C 120 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 C 120 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 V 202 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM7 L 288 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 288 7x56 G.H5 G 352 G.H5.24
Ionic H8 K 290 8x48 G.h4s6 E 318 G.h4s6.12
Polar H8 K 290 8x48 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 K 290 8x48 G.h4s6 E 318 G.h4s6.12
Ionic TM1 K 42 1x60 G.h4s6 D 315 G.h4s6.09
Polar TM1 K 42 1x60 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM1 K 42 1x60 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM1 K 42 1x60 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 A 221 6x33 G.H5 F 354 G.H5.26
Polar TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 221 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 221 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL1 N 45 - G.h4s6 V 316 G.h4s6.10
Van-der-waals ICL1 N 45 - G.h4s6 V 316 G.h4s6.10
Hydrophobic TM1 K 42 1x60 G.h4s6 V 316 G.h4s6.10
Polar TM3 H 118 3x56 G.S1 T 33 G.S1.01
Polar ICL2 S 119 34x50 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 S 119 34x50 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 119 34x50 G.hns1 A 31 G.hns1.02
Polar ICL2 Y 123 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 Y 123 34x54 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 Y 123 34x54 G.h2s4 T 219 G.h2s4.05
Polar ICL2 Y 123 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 123 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 123 34x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 225 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 225 6x37 G.H5 L 353 G.H5.25
Ionic TM2 R 47 2x37 G.H5 E 346 G.H5.18
Polar TM2 R 47 2x37 G.H5 E 346 G.H5.18