Ggust - GPR171 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 123 34x54 G.S1 V 34 G.S1.02
Polar TM2 V 49 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 V 49 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 49 2x39 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 123 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 Q 126 34x57 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Q 126 34x57 G.H5 L 348 G.H5.20
Van-der-waals ICL2 Q 126 34x57 G.H5 L 348 G.H5.20
Polar ICL2 K 121 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 121 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 121 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 R 47 2x37 G.H5 G 352 G.H5.24
Hydrophobic TM3 D 111 3x49 G.H5 L 353 G.H5.25
Van-der-waals TM3 D 111 3x49 G.H5 L 353 G.H5.25
Polar ICL2 R 124 34x55 G.HN A 27 G.HN.51
Hydrophobic ICL2 R 124 34x55 G.HN A 27 G.HN.51
Hydrophobic TM3 L 116 3x54 G.H5 F 354 G.H5.26
Ionic TM2 R 47 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 47 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 47 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 47 2x37 G.H5 D 350 G.H5.22
Polar TM3 D 111 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 111 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 111 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 114 3x52 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 114 3x52 G.H5 L 348 G.H5.20
Polar TM3 Q 115 3x53 G.H5 F 354 G.H5.26
Polar ICL2 C 120 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 C 120 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 C 120 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM2 V 49 2x39 G.H5 L 353 G.H5.25
Polar H8 K 290 8x48 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 K 290 8x48 G.h4s6 E 315 G.h4s6.09
Polar TM2 C 48 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 C 48 2x38 G.H5 D 350 G.H5.22
Hydrophobic ICL2 C 120 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 C 120 34x51 G.s2s3 D 193 G.s2s3.02
Ionic ICL2 K 121 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 121 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 121 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 121 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 Q 126 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Q 126 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Q 126 34x57 G.H5 C 351 G.H5.23
Polar ICL1 H 46 - G.h3s5 T 261 G.h3s5.02
Hydrophobic ICL1 H 46 - G.h3s5 T 261 G.h3s5.02
Van-der-waals ICL1 H 46 - G.h3s5 T 261 G.h3s5.02
Polar ICL2 Y 123 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 Y 123 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Y 123 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 H 118 3x56 G.H5 K 345 G.H5.17
Hydrophobic TM3 H 118 3x56 G.H5 I 344 G.H5.16
Hydrophobic TM2 V 49 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 V 49 2x39 G.H5 G 352 G.H5.24
Polar TM3 Q 115 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM3 Q 115 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 Q 115 3x53 G.H5 L 348 G.H5.20
Polar ICL2 Y 123 34x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 Y 123 34x54 G.H5 I 344 G.H5.16
Van-der-waals ICL2 Y 123 34x54 G.H5 I 344 G.H5.16
Ionic ICL2 R 124 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 124 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 124 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 124 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 124 34x55 G.HN R 29 G.HN.53
Hydrophobic ICL2 R 124 34x55 G.HN R 29 G.HN.53
Van-der-waals ICL2 R 124 34x55 G.HN R 29 G.HN.53
Polar TM3 Q 115 3x53 G.H5 K 349 G.H5.21
Hydrophobic TM2 C 48 2x38 G.H5 C 351 G.H5.23
Van-der-waals TM2 C 48 2x38 G.H5 C 351 G.H5.23
Polar TM2 R 47 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM2 R 47 2x37 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 47 2x37 G.H5 K 349 G.H5.21
Polar TM3 Q 115 3x53 G.H5 L 353 G.H5.25
Hydrophobic TM3 Q 115 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 Q 115 3x53 G.H5 L 353 G.H5.25
Polar TM2 R 47 2x37 G.H5 F 354 G.H5.26
Hydrophobic TM2 R 47 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 112 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 123 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Y 123 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Y 123 34x54 G.S3 L 194 G.S3.01
Van-der-waals TM7 L 288 7x56 G.H5 G 352 G.H5.24
Polar ICL2 R 124 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 124 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 124 34x55 G.hns1 A 31 G.hns1.02
Polar ICL2 C 120 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 C 120 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 C 120 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 V 108 3x46 G.H5 L 353 G.H5.25
Van-der-waals TM3 V 108 3x46 G.H5 L 353 G.H5.25
Hydrophobic ICL2 C 120 34x51 G.H5 T 340 G.H5.12
Polar TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Q 115 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 E 127 4x38 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 E 127 4x38 G.hns1 A 31 G.hns1.02
Hydrophobic TM7 L 288 7x56 G.H5 L 353 G.H5.25
Ionic TM1 K 42 1x60 G.h4s6 D 316 G.h4s6.10
Polar TM1 K 42 1x60 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM1 K 42 1x60 G.h4s6 D 316 G.h4s6.10
Van-der-waals TM1 K 42 1x60 G.h4s6 D 316 G.h4s6.10
Polar ICL2 Y 123 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 123 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 123 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 123 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM3 Q 115 3x53 G.H5 G 352 G.H5.24
Van-der-waals TM3 Q 115 3x53 G.H5 G 352 G.H5.24
Hydrophobic ICL2 C 120 34x51 G.H5 I 344 G.H5.16
Van-der-waals ICL2 C 120 34x51 G.H5 I 344 G.H5.16
Polar C-term N 317 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 R 124 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 124 34x55 G.hns1 R 32 G.hns1.03
Ionic TM2 R 47 2x37 G.H5 E 346 G.H5.18