G12 - GPR174 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL1 R 53 - G.H5 D 377 G.H5.22
Polar ICL1 R 53 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 R 53 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 R 53 - G.H5 D 377 G.H5.22
Hydrophobic ICL3 M 218 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 M 218 - G.H5 D 368 G.H5.13
Polar TM4 Y 133 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 Y 133 4x41 G.HN R 52 G.HN.52
Hydrophobic TM2 M 58 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 58 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 112 3x46 G.H5 Q 381 G.H5.26
Van-der-waals TM3 I 112 3x46 G.H5 Q 381 G.H5.26
Polar ICL2 F 126 34x53 G.H5 N 374 G.H5.19
Polar TM7 S 295 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 124 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 124 34x51 G.S3 I 221 G.S3.01
Ionic ICL2 H 127 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 H 127 34x54 G.H5 E 373 G.H5.18
Polar TM3 F 119 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 F 119 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 F 119 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 L 212 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL3 M 218 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 M 218 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 A 219 - G.S6 F 347 G.S6.02
Polar TM1 Y 47 1x60 G.H5 D 377 G.H5.22
Hydrophobic ICL2 H 127 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 H 127 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 A 228 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 228 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 123 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM3 L 120 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 120 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM4 K 130 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 K 130 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL3 Q 220 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 220 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 L 222 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 L 222 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 F 124 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 124 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM2 V 55 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 V 55 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM2 V 55 2x40 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 124 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM3 R 115 3x49 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 115 3x49 G.H5 Q 381 G.H5.26
Polar TM3 R 116 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 116 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 116 3x50 G.H5 I 378 G.H5.23
Polar TM3 R 116 3x50 G.H5 Q 381 G.H5.26
Hydrophobic TM3 R 116 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 116 3x50 G.H5 Q 381 G.H5.26
Ionic TM6 E 224 6x29 G.H5 K 376 G.H5.21
Polar TM6 E 224 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 E 224 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 E 224 6x29 G.H5 K 376 G.H5.21
Hydrophobic ICL2 P 123 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 123 34x50 G.H5 I 370 G.H5.15
Hydrophobic H8 E 298 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 E 298 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM6 M 231 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 231 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 124 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 K 227 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 125 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 M 218 - G.H5 L 371 G.H5.16
Aromatic ICL3 Y 216 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 Y 216 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 Y 216 - G.H5 H 364 G.H5.09
Aromatic ICL2 F 124 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 124 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 124 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM4 K 130 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic H8 T 296 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 296 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 T 296 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 T 296 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 124 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 124 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 L 120 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 120 3x54 G.H5 L 371 G.H5.16
Polar ICL2 H 127 34x54 G.H5 N 374 G.H5.19
Hydrophobic TM2 M 58 2x43 G.H5 Q 381 G.H5.26
Van-der-waals TM2 M 58 2x43 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 124 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 124 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM3 L 120 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM1 Y 47 1x60 G.H5 L 380 G.H5.25
Van-der-waals TM1 Y 47 1x60 G.H5 L 380 G.H5.25
Ionic ICL2 D 128 34x55 G.hns1 R 55 G.hns1.02
Polar ICL2 D 128 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 D 128 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 D 128 34x55 G.hns1 R 55 G.hns1.02
Polar ICL2 C 129 34x56 G.H5 Q 381 G.H5.26
Van-der-waals ICL2 C 129 34x56 G.H5 Q 381 G.H5.26
Polar ICL3 Q 220 - G.S6 L 346 G.S6.01
Hydrophobic TM3 F 119 3x53 G.H5 Q 381 G.H5.26
Hydrophobic TM6 M 231 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 231 6x36 G.H5 I 378 G.H5.23
Polar ICL3 Q 220 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 L 222 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 L 222 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 F 119 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 123 34x50 G.H5 K 367 G.H5.12
Ionic ICL1 R 53 - G.H5 E 373 G.H5.18
Polar ICL1 R 53 - G.H5 E 373 G.H5.18
Van-der-waals ICL1 R 53 - G.H5 E 373 G.H5.18
Hydrophobic TM6 K 225 6x30 G.H5 L 375 G.H5.20