GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | E | 224 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | E | 224 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | F | 124 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Aromatic | TM3 | F | 119 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | F | 119 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Ionic | TM6 | E | 224 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM6 | E | 224 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | E | 224 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | F | 124 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 124 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Polar | ICL1 | R | 53 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL1 | R | 53 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL1 | R | 53 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | H | 127 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Polar | ICL3 | Y | 216 | - | G.H5 | R | 360 | G.H5.12 |
Aromatic | ICL3 | Y | 216 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL3 | Y | 216 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL3 | Y | 216 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL3 | P | 217 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | P | 217 | - | G.H5 | K | 357 | G.H5.09 |
Ionic | ICL1 | R | 53 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL1 | R | 53 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL1 | R | 53 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | R | 53 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | F | 124 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 124 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | F | 124 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | F | 124 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Polar | TM3 | R | 116 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM3 | R | 116 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | H | 127 | 34x54 | G.H5 | R | 366 | G.H5.18 |
Hydrophobic | ICL2 | H | 127 | 34x54 | G.H5 | R | 366 | G.H5.18 |
Van-der-waals | ICL2 | H | 127 | 34x54 | G.H5 | R | 366 | G.H5.18 |
Polar | TM6 | A | 228 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 228 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | A | 228 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | M | 218 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | M | 218 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | K | 227 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 227 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Ionic | ICL2 | D | 128 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL2 | D | 128 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | D | 128 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | D | 128 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | L | 120 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | L | 120 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | H8 | R | 305 | 8x56 | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | H8 | R | 305 | 8x56 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM2 | M | 58 | 2x43 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM2 | M | 58 | 2x43 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL3 | M | 218 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL3 | M | 218 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | M | 218 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM3 | L | 120 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | L | 120 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL3 | Y | 216 | - | G.H5 | K | 357 | G.H5.09 |
Polar | TM3 | R | 116 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 116 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 116 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | F | 124 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM3 | R | 116 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | R | 116 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | Y | 216 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | L | 212 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | L | 120 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | L | 120 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | L | 120 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | M | 231 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | M | 231 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | M | 231 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | M | 231 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Polar | H8 | T | 296 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | T | 296 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | T | 296 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | F | 119 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | F | 119 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM4 | K | 130 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Aromatic | ICL2 | F | 124 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 124 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 124 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | P | 123 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 123 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM2 | M | 58 | 2x43 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | I | 232 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | I | 232 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | N | 297 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | N | 297 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | N | 297 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | T | 296 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | T | 296 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL3 | M | 218 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | A | 228 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | A | 228 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Polar | ICL2 | P | 123 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 123 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | P | 123 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 123 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 123 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | ICL2 | H | 127 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | H | 127 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | H | 127 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | H8 | N | 297 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | N | 297 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |