Gi3 - GPR183 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 132 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 238 6x29 G.H5 K 345 G.H5.17
Polar ICL3 T 233 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 T 233 - G.H5 D 341 G.H5.13
Hydrophobic TM6 I 249 6x40 G.H5 L 353 G.H5.25
Ionic TM4 R 144 4x38 G.HN E 28 G.HN.52
Polar TM4 R 144 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 144 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 144 4x38 G.HN E 28 G.HN.52
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Polar TM3 R 129 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 133 3x54 G.H5 I 344 G.H5.16
Polar TM5 N 230 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 N 230 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 137 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 137 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 A 242 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Y 139 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 141 34x55 G.hns1 K 32 G.hns1.03
Polar TM2 T 66 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM3 V 133 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 133 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 136 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 246 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM7 F 310 7x55 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 310 7x55 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 238 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 232 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 L 232 - G.S6 T 321 G.S6.03
Hydrophobic ICL2 L 137 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 137 34x51 G.s2s3 K 192 G.s2s3.01
Ionic ICL2 K 143 34x57 G.H5 E 350 G.H5.22
Polar ICL2 K 143 34x57 G.H5 E 350 G.H5.22
Hydrophobic ICL2 K 143 34x57 G.H5 E 350 G.H5.22
Van-der-waals ICL2 K 143 34x57 G.H5 E 350 G.H5.22
Ionic TM4 E 146 4x40 G.HN R 24 G.HN.48
Polar TM4 E 146 4x40 G.HN R 24 G.HN.48
Hydrophobic TM4 E 146 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 E 146 4x40 G.HN R 24 G.HN.48
Hydrophobic TM5 L 223 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 245 6x36 G.H5 L 353 G.H5.25
Polar ICL2 P 136 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 136 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 N 140 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 P 136 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 R 129 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 K 222 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 222 5x64 G.H5 I 344 G.H5.16
Polar TM3 R 129 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 C 351 G.H5.23
Polar TM7 A 311 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 A 311 7x56 G.H5 G 352 G.H5.24
Polar TM2 N 64 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 N 64 2x37 G.H5 E 350 G.H5.22
Ionic H8 K 313 8x48 G.H5 E 350 G.H5.22
Polar H8 K 313 8x48 G.H5 E 350 G.H5.22
Hydrophobic H8 K 313 8x48 G.H5 E 350 G.H5.22
Hydrophobic TM6 V 238 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 V 238 6x29 G.H5 Y 354 G.H5.26
Polar TM5 T 226 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 T 226 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 T 226 5x68 G.H5 D 341 G.H5.13
Polar TM6 A 242 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 242 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 242 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 223 5x65 G.H5 L 348 G.H5.20
Polar ICL2 N 140 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 N 140 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 N 140 34x54 G.hns1 A 31 G.hns1.02
Polar ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Polar TM3 A 132 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 132 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 132 3x53 G.H5 N 347 G.H5.19