G15 -
GPRC6 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 871 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | L | 871 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | A | 365 | G.H5.17 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | C-term | A | 902 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | A | 902 | - | G.H3 | W | 266 | G.H3.17 |
Polar | C-term | S | 857 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | S | 857 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | C-term | S | 857 | - | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | S | 857 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | S | 857 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | C-term | S | 857 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | Q | 899 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | Q | 899 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | S | 860 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | C-term | S | 860 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | C-term | F | 903 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | F | 903 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | I | 864 | - | G.H5 | R | 353 | G.H5.05 |
Van-der-waals | C-term | I | 864 | - | G.H5 | R | 353 | G.H5.05 |
Polar | C-term | S | 860 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | S | 860 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | C-term | S | 860 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | I | 864 | - | G.H5 | F | 356 | G.H5.08 |
Polar | ICL2 | Q | 695 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | Q | 695 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | Q | 695 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | F | 849 | 8x54 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | I | 864 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | C-term | V | 861 | - | G.H5 | R | 353 | G.H5.05 |
Hydrophobic | C-term | I | 864 | - | G.S2 | V | 199 | G.S2.08 |
Van-der-waals | C-term | I | 864 | - | G.S2 | V | 199 | G.S2.08 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 368 | G.H5.20 |
Ionic | C-term | K | 888 | - | G.HN | D | 25 | G.HN.40 |
Polar | C-term | K | 888 | - | G.HN | D | 25 | G.HN.40 |
Van-der-waals | C-term | K | 888 | - | G.HN | D | 25 | G.HN.40 |
Hydrophobic | C-term | I | 853 | - | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | C-term | I | 853 | - | G.H5 | L | 364 | G.H5.16 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | V | 861 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | C-term | L | 866 | - | G.H5 | I | 352 | G.H5.04 |
Hydrophobic | C-term | V | 861 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | V | 363 | G.H5.15 |
Polar | ICL2 | F | 690 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | C | 907 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | H8 | K | 846 | 8x51 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | K | 846 | 8x51 | G.H5 | L | 374 | G.H5.26 |
Ionic | C-term | H | 905 | - | G.H3 | E | 263 | G.H3.14 |
Hydrophobic | C-term | L | 871 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | I | 906 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | C-term | S | 857 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | L | 850 | 8x55 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | E | 909 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | E | 909 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | I | 906 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | L | 364 | G.H5.16 |
Ionic | ICL2 | K | 699 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | K | 699 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | K | 699 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | K | 693 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | I | 853 | - | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | C-term | I | 853 | - | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | L | 871 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | P | 868 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | ICL1 | K | 625 | 12x51 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | M | 880 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | TM3 | L | 686 | 3x56 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | I | 906 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | A | 902 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | A | 902 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | C-term | L | 871 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | I | 906 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | A | 902 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | Q | 899 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | H8 | L | 850 | 8x55 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | H8 | L | 850 | 8x55 | G.h4s6 | R | 338 | G.h4s6.20 |
Ionic | H8 | K | 846 | 8x51 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 846 | 8x51 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | C-term | L | 898 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | L | 898 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL2 | K | 696 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | K | 696 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | S | 867 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | S | 858 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | C-term | S | 858 | - | G.H5 | K | 357 | G.H5.09 |
Polar | C-term | S | 863 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | C-term | S | 863 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | C-term | A | 869 | - | G.S2 | S | 198 | G.S2.07 |
Polar | ICL1 | S | 626 | 12x52 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL1 | S | 626 | 12x52 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | ICL1 | S | 626 | 12x52 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | F | 688 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | Y | 856 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | L | 866 | - | G.S2 | S | 198 | G.S2.07 |
Polar | C-term | N | 910 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | N | 910 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | N | 910 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | ICL2 | P | 692 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | L | 898 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | L | 898 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | H8 | K | 846 | 8x51 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | K | 846 | 8x51 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | K | 693 | - | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | K | 699 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | K | 699 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | P | 868 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | L | 871 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | C-term | V | 861 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | C-term | V | 861 | - | G.H5 | R | 360 | G.H5.12 |
Aromatic | ICL2 | F | 690 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | L | 866 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | L | 866 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | C-term | H | 905 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | R | 40 | G.hns1.02 |
Polar | C-term | Y | 854 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | L | 866 | - | G.S2 | V | 199 | G.S2.08 |
Polar | C-term | Y | 854 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | Y | 854 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | C-term | Y | 854 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 692 | - | G.S1 | L | 43 | G.S1.02 |