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GPRC6 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | S | 857 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | S | 857 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | C-term | S | 857 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | K | 693 | - | G.HN | I | 28 | G.HN.52 |
Hydrophobic | C-term | R | 908 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | L | 850 | 8x55 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | V | 861 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | C-term | V | 861 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | Y | 856 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | C-term | Y | 856 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | I | 906 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Van-der-waals | C-term | I | 906 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | C-term | S | 860 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | C-term | S | 860 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | C-term | S | 860 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | TM3 | A | 687 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL1 | K | 625 | 12x51 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | S | 858 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | S | 858 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | C-term | S | 858 | - | G.H5 | D | 337 | G.H5.09 |
Polar | C-term | Y | 854 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | C-term | Y | 854 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | C-term | Y | 854 | - | G.S6 | H | 322 | G.S6.04 |
Polar | ICL1 | S | 626 | 12x52 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL1 | S | 626 | 12x52 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL1 | S | 626 | 12x52 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 906 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | I | 906 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | F | 690 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | Y | 854 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | A | 911 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | A | 911 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | V | 861 | - | G.S2 | F | 192 | G.S2.08 |
Van-der-waals | C-term | V | 861 | - | G.S2 | F | 192 | G.S2.08 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL1 | K | 625 | 12x51 | G.H5 | Y | 354 | G.H5.26 |
Aromatic | C-term | F | 903 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | C-term | F | 903 | - | H.HA | Y | 69 | H.HA.07 |
Van-der-waals | C-term | F | 903 | - | H.HA | Y | 69 | H.HA.07 |
Polar | ICL2 | K | 696 | - | G.HN | K | 24 | G.HN.48 |
Van-der-waals | ICL2 | K | 696 | - | G.HN | K | 24 | G.HN.48 |
Polar | C-term | S | 857 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | S | 857 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | C-term | S | 857 | - | G.H5 | D | 337 | G.H5.09 |
Polar | C-term | Q | 899 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | C-term | Q | 899 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | Q | 899 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | D | 337 | G.H5.09 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | I | 864 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | C-term | I | 864 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | C-term | F | 903 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | F | 903 | - | H.HA | Q | 68 | H.HA.06 |
Ionic | C-term | K | 896 | - | H.HA | E | 64 | H.HA.02 |
Polar | C-term | K | 896 | - | H.HA | E | 64 | H.HA.02 |
Van-der-waals | C-term | K | 896 | - | H.HA | E | 64 | H.HA.02 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | I | 853 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | C-term | I | 853 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | I | 853 | - | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | L | 348 | G.H5.20 |
Polar | H8 | K | 846 | 8x51 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | K | 846 | 8x51 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | K | 846 | 8x51 | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL2 | Q | 695 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | Q | 695 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL1 | S | 627 | 12x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | K | 696 | - | G.HN | I | 28 | G.HN.52 |
Van-der-waals | ICL2 | K | 696 | - | G.HN | I | 28 | G.HN.52 |
Ionic | ICL2 | D | 691 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | D | 691 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | D | 691 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | I | 853 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | V | 861 | - | G.H5 | Q | 333 | G.H5.05 |
Van-der-waals | C-term | V | 861 | - | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | C-term | S | 857 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | C-term | S | 857 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | L | 686 | 3x56 | G.H5 | C | 351 | G.H5.23 |
Ionic | H8 | K | 846 | 8x51 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | H8 | K | 846 | 8x51 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | H8 | K | 846 | 8x51 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | H8 | K | 846 | 8x51 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | C | 907 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | C | 907 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | C-term | V | 861 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | C-term | V | 861 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | Y | 778 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | H8 | L | 850 | 8x55 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | H8 | L | 850 | 8x55 | G.h4s6 | E | 318 | G.h4s6.12 |
Aromatic | H8 | F | 849 | 8x54 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | F | 849 | 8x54 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | F | 688 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | F | 688 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | K | 693 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM2 | G | 628 | 2x34 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | G | 628 | 2x34 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 348 | G.H5.20 |
Polar | H8 | K | 846 | 8x51 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | H8 | K | 846 | 8x51 | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | C-term | F | 903 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | F | 903 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | C-term | Y | 854 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | C-term | I | 853 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | C-term | I | 853 | - | G.H5 | D | 341 | G.H5.13 |