Gs -
GPRC6 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | A | 902 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | T | 879 | - | G.h1ha | E | 74 | G.h1ha.10 |
Hydrophobic | C-term | T | 879 | - | G.h1ha | E | 74 | G.h1ha.10 |
Van-der-waals | C-term | T | 879 | - | G.h1ha | E | 74 | G.h1ha.10 |
Hydrophobic | C-term | V | 861 | - | G.H5 | N | 377 | G.H5.09 |
Van-der-waals | C-term | V | 861 | - | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | C-term | S | 858 | - | G.H5 | N | 377 | G.H5.09 |
Polar | C-term | S | 857 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | S | 857 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | C-term | S | 857 | - | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | A | 687 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | F | 849 | 8x54 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | C-term | S | 857 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | I | 853 | - | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | K | 696 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | K | 696 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM3 | L | 686 | 3x56 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | L | 686 | 3x56 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | F | 903 | - | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | C-term | F | 903 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | C-term | Y | 854 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | C-term | A | 902 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | A | 902 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | A | 902 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | C-term | F | 903 | - | G.H2 | R | 231 | G.H2.04 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | M | 880 | - | G.h1ha | E | 74 | G.h1ha.10 |
Hydrophobic | C-term | M | 880 | - | G.h1ha | E | 74 | G.h1ha.10 |
Van-der-waals | C-term | M | 880 | - | G.h1ha | E | 74 | G.h1ha.10 |
Hydrophobic | C-term | V | 861 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | C-term | V | 861 | - | G.H5 | F | 376 | G.H5.08 |
Polar | TM3 | A | 687 | 3x57 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | C-term | I | 853 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | I | 853 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | C-term | I | 853 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | M | 880 | - | G.h1ha | P | 77 | G.h1ha.13 |
Hydrophobic | TM3 | F | 688 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | F | 688 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | Y | 854 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | V | 861 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | M | 880 | - | G.h1ha | E | 75 | G.h1ha.11 |
Van-der-waals | C-term | M | 880 | - | G.h1ha | E | 75 | G.h1ha.11 |
Polar | ICL2 | Q | 695 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Q | 695 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Q | 695 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | F | 903 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | C-term | A | 865 | - | G.H5 | R | 373 | G.H5.05 |
Van-der-waals | C-term | A | 865 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | C-term | F | 903 | - | G.H2 | R | 232 | G.H2.05 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | I | 383 | G.H5.15 |
Ionic | TM5 | E | 776 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | I | 864 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | C-term | I | 864 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | S | 857 | - | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | C-term | V | 861 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | TM3 | F | 688 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | S | 862 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | H8 | K | 846 | 8x51 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | K | 846 | 8x51 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL3 | Y | 778 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | H8 | L | 850 | 8x55 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | H8 | L | 850 | 8x55 | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | C-term | Y | 854 | - | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | C-term | V | 878 | - | G.h1ha | E | 74 | G.h1ha.10 |
Van-der-waals | C-term | V | 878 | - | G.h1ha | E | 74 | G.h1ha.10 |
Polar | H8 | L | 850 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | H8 | L | 850 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Polar | C-term | Y | 854 | - | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | D | 378 | G.H5.10 |
Polar | ICL1 | S | 626 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL1 | S | 626 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL1 | S | 626 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | K | 699 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | K | 699 | - | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | S | 860 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | S | 860 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | C-term | S | 860 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | L | 850 | 8x55 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM2 | G | 628 | 2x34 | G.H5 | L | 393 | G.H5.25 |
Polar | H8 | K | 846 | 8x51 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | Y | 778 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL1 | K | 625 | 12x51 | G.H5 | E | 392 | G.H5.24 |