G12 - GPR15 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 77.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 139 34x51 G.H5 I 370 G.H5.15
Polar ICL2 S 141 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 S 141 34x53 G.H5 N 374 G.H5.19
Polar TM4 R 146 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 R 146 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 R 146 4x38 G.HN R 52 G.HN.52
Hydrophobic TM2 R 66 2x37 G.H5 L 380 G.H5.25
Van-der-waals TM2 R 66 2x37 G.H5 L 380 G.H5.25
Hydrophobic ICL2 K 143 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 K 235 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 235 6x29 G.H5 M 379 G.H5.24
Polar ICL2 P 138 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 138 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 I 243 6x37 G.H5 I 378 G.H5.23
Van-der-waals H8 R 311 8x52 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 V 139 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 I 135 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Polar TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 139 34x51 G.H5 K 367 G.H5.12
Hydrophobic H8 D 306 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 306 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 145 34x57 G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 145 34x57 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 236 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 236 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM2 I 68 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 I 68 2x39 G.H5 I 378 G.H5.23
Hydrophobic H8 Y 308 8x49 G.H5 Q 381 G.H5.26
Polar C-term S 329 - G.H3 K 284 G.H3.16
Polar ICL2 R 142 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 142 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 142 34x54 G.h2s4 T 246 G.h2s4.05
Polar TM6 K 235 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 235 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 235 6x29 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 341 - G.H2 F 239 G.H2.08
Polar H8 Y 308 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 Y 308 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 Y 308 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 L 371 G.H5.16
Ionic ICL2 R 142 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 142 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 142 34x54 G.H5 E 373 G.H5.18
Hydrophobic TM6 L 236 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 236 6x30 G.H5 M 379 G.H5.24
Hydrophobic C-term L 337 - G.H3 L 285 G.H3.17
Van-der-waals C-term L 337 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 P 138 34x50 G.H5 L 371 G.H5.16
Hydrophobic C-term F 344 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 344 - G.H3 T 279 G.H3.11
Polar H8 S 307 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 307 8x48 G.H5 L 380 G.H5.25
Polar TM6 S 239 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 S 239 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 239 6x33 G.H5 M 379 G.H5.24
Ionic TM4 D 148 4x40 G.HN R 52 G.HN.52
Polar TM4 D 148 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 D 148 4x40 G.HN R 52 G.HN.52
Hydrophobic TM5 H 225 5x68 G.H5 L 371 G.H5.16
Ionic TM5 H 225 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 225 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 225 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 225 5x68 G.H5 D 368 G.H5.13
Polar ICL2 R 145 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 145 34x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 142 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 142 34x54 G.H5 I 370 G.H5.15
Polar TM6 S 239 6x33 G.H5 I 378 G.H5.23
Hydrophobic TM6 I 242 6x36 G.H5 L 380 G.H5.25
Ionic C-term E 348 - G.H2 R 232 G.H2.01
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 R 142 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 142 34x54 G.hns1 R 55 G.hns1.02
Ionic ICL2 R 145 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM3 A 134 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM4 R 146 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 R 146 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 I 68 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 222 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 139 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 P 138 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 138 34x50 G.H5 K 367 G.H5.12