GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 337 | - | G.H3 | N | 256 | G.H3.15 |
Van-der-waals | C-term | L | 337 | - | G.H3 | N | 256 | G.H3.15 |
Hydrophobic | TM2 | I | 68 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | I | 68 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Polar | C-term | G | 327 | - | G.H3 | K | 257 | G.H3.16 |
Polar | ICL2 | R | 142 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | ICL3 | H | 232 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | H | 232 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | H | 232 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | K | 235 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 341 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | C-term | L | 341 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | L | 341 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | L | 222 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | Y | 151 | 4x43 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | Y | 151 | 4x43 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | C-term | F | 344 | - | G.H2 | R | 205 | G.H2.01 |
Polar | TM6 | K | 235 | 6x29 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM4 | T | 147 | 4x39 | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | R | 145 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | F | 344 | - | G.H3 | E | 245 | G.H3.04 |
Van-der-waals | C-term | F | 344 | - | G.H3 | E | 245 | G.H3.04 |
Hydrophobic | C-term | I | 345 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | I | 345 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM6 | S | 239 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | V | 139 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | V | 139 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Ionic | ICL2 | K | 143 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | K | 143 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 143 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Ionic | ICL3 | H | 232 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | H | 232 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | H | 232 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | H | 232 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Ionic | TM6 | K | 235 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 235 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 235 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 235 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM2 | R | 66 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | R | 66 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 66 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Polar | TM2 | R | 66 | 2x37 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM2 | R | 66 | 2x37 | G.H5 | K | 349 | G.H5.21 |
Ionic | C-term | E | 348 | - | G.H2 | R | 205 | G.H2.01 |
Polar | C-term | E | 348 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | E | 348 | - | G.H2 | R | 205 | G.H2.01 |
Van-der-waals | C-term | E | 348 | - | G.H2 | R | 205 | G.H2.01 |
Ionic | TM4 | R | 146 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 146 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 146 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 146 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM2 | I | 68 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM4 | T | 147 | 4x39 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | T | 147 | 4x39 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | T | 147 | 4x39 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | I | 243 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | S | 328 | - | G.H3 | K | 257 | G.H3.16 |
Polar | H8 | S | 307 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | S | 307 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | K | 238 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | S | 239 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 239 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 337 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | V | 139 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | V | 139 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL2 | V | 139 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | V | 139 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | ICL2 | P | 138 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Ionic | C-term | K | 355 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Polar | C-term | K | 355 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | K | 355 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | ICL3 | K | 231 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM2 | R | 66 | 2x37 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | R | 66 | 2x37 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | F | 344 | - | G.H3 | K | 248 | G.H3.07 |
Polar | ICL2 | R | 142 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | H | 225 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | H | 225 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | A | 134 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 134 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | K | 221 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL2 | R | 145 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | R | 145 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 145 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 145 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Polar | TM2 | L | 67 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Ionic | ICL3 | K | 231 | - | G.H4 | E | 308 | G.H4.16 |
Polar | ICL3 | K | 231 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | K | 231 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 135 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM5 | H | 225 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 225 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 225 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 225 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | H8 | D | 306 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | D | 306 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | T | 338 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Polar | ICL2 | R | 142 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Ionic | TM4 | D | 148 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | TM4 | D | 148 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | D | 148 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | D | 148 | 4x40 | G.HN | R | 24 | G.HN.48 |
Ionic | C-term | D | 325 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Hydrophobic | TM5 | L | 222 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | L | 337 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | L | 337 | - | G.H2 | I | 212 | G.H2.08 |
Polar | ICL3 | S | 229 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | S | 229 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | K | 143 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | K | 143 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 143 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM6 | I | 242 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 242 | 6x36 | G.H5 | L | 353 | G.H5.25 |