Gt1 - GPR15 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 82.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic C-term E 348 - G.H2 R 201 G.H2.01
Polar C-term E 348 - G.H2 R 201 G.H2.01
Hydrophobic C-term E 348 - G.H2 R 201 G.H2.01
Van-der-waals C-term E 348 - G.H2 R 201 G.H2.01
Hydrophobic TM2 I 68 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 I 68 2x39 G.H5 D 346 G.H5.22
Hydrophobic C-term F 344 - G.H3 L 245 G.H3.08
Hydrophobic TM6 I 242 6x36 G.H5 L 349 G.H5.25
Van-der-waals TM6 I 242 6x36 G.H5 L 349 G.H5.25
Polar TM6 K 235 6x29 G.h4s6 D 311 G.h4s6.09
Van-der-waals TM6 K 235 6x29 G.h4s6 D 311 G.h4s6.09
Hydrophobic TM6 K 235 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 235 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM4 R 146 4x38 G.HN K 20 G.HN.48
Van-der-waals TM4 R 146 4x38 G.HN K 20 G.HN.48
Hydrophobic ICL2 K 143 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 K 143 34x55 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 P 138 34x50 G.H5 I 339 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 339 G.H5.15
Van-der-waals C-term L 337 - G.H3 R 253 G.H3.16
Ionic TM4 R 146 4x38 G.HN E 24 G.HN.52
Polar TM4 R 146 4x38 G.HN E 24 G.HN.52
Hydrophobic TM4 R 146 4x38 G.HN E 24 G.HN.52
Van-der-waals TM4 R 146 4x38 G.HN E 24 G.HN.52
Polar ICL2 R 145 34x57 G.H5 C 347 G.H5.23
Hydrophobic ICL2 R 145 34x57 G.H5 C 347 G.H5.23
Van-der-waals ICL2 R 145 34x57 G.H5 C 347 G.H5.23
Hydrophobic H8 D 306 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 D 306 8x47 G.H5 G 348 G.H5.24
Polar TM6 K 238 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 K 238 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 238 6x32 G.H5 F 350 G.H5.26
Polar TM3 D 130 3x49 G.H5 C 347 G.H5.23
Ionic TM5 H 225 5x68 G.H5 D 337 G.H5.13
Polar TM5 H 225 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 H 225 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 H 225 5x68 G.H5 D 337 G.H5.13
Hydrophobic C-term F 344 - G.H3 H 252 G.H3.15
Van-der-waals C-term F 344 - G.H3 H 252 G.H3.15
Hydrophobic TM3 I 135 3x54 G.H5 L 349 G.H5.25
Ionic ICL2 K 143 34x55 G.HN E 24 G.HN.52
Hydrophobic ICL2 K 143 34x55 G.HN E 24 G.HN.52
Van-der-waals ICL2 K 143 34x55 G.HN E 24 G.HN.52
Ionic TM6 K 235 6x29 G.h4s6 E 314 G.h4s6.12
Polar TM6 K 235 6x29 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 K 235 6x29 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 I 243 6x37 G.H5 L 349 G.H5.25
Polar TM3 R 131 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 347 G.H5.23
Hydrophobic C-term F 344 - G.H3 I 249 G.H3.12
Hydrophobic TM3 A 134 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM6 S 239 6x33 G.H5 L 344 G.H5.20
Polar ICL2 R 142 34x54 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 R 142 34x54 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 R 142 34x54 G.hns1 A 27 G.hns1.02
Polar TM2 R 66 2x37 G.H5 K 345 G.H5.21
Van-der-waals TM2 R 66 2x37 G.H5 K 345 G.H5.21
Hydrophobic TM5 H 225 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 H 225 5x68 G.H5 I 340 G.H5.16
Hydrophobic TM3 R 131 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM5 L 222 5x65 G.H5 I 340 G.H5.16
Hydrophobic ICL2 P 138 34x50 G.H5 I 340 G.H5.16
Hydrophobic C-term A 340 - G.H3 R 253 G.H3.16
Van-der-waals C-term A 340 - G.H3 R 253 G.H3.16
Polar TM6 S 239 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 S 239 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 S 239 6x33 G.H5 L 349 G.H5.25
Polar C-term H 336 - G.H3 R 253 G.H3.16
Hydrophobic C-term H 336 - G.H3 R 253 G.H3.16
Van-der-waals C-term H 336 - G.H3 R 253 G.H3.16
Polar ICL2 R 145 34x57 G.H5 N 343 G.H5.19
Polar C-term L 337 - G.H3 Y 254 G.H3.17
Hydrophobic C-term L 337 - G.H3 Y 254 G.H3.17
Van-der-waals C-term L 337 - G.H3 Y 254 G.H3.17
Hydrophobic C-term L 341 - G.H2 I 208 G.H2.08
Van-der-waals C-term L 341 - G.H2 I 208 G.H2.08
Hydrophobic C-term F 326 - G.h4s6 R 309 G.h4s6.04
Polar TM3 A 134 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 343 G.H5.19
Ionic C-term K 355 - G.s4h3 E 235 G.s4h3.13
Polar C-term K 355 - G.s4h3 E 235 G.s4h3.13
Van-der-waals C-term K 355 - G.s4h3 E 235 G.s4h3.13
Hydrophobic TM3 I 135 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 344 G.H5.20
Hydrophobic TM5 K 221 5x64 G.H5 I 340 G.H5.16
Hydrophobic ICL2 V 139 34x51 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 V 139 34x51 G.s2s3 D 189 G.s2s3.02
Ionic ICL2 R 142 34x54 G.H5 E 342 G.H5.18
Polar ICL2 R 142 34x54 G.H5 E 342 G.H5.18
Hydrophobic TM5 L 222 5x65 G.H5 L 344 G.H5.20
Hydrophobic C-term I 345 - G.H2 K 205 G.H2.05
Hydrophobic ICL2 V 139 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 L 190 G.S3.01
Hydrophobic TM6 I 242 6x36 G.H5 F 350 G.H5.26
Polar TM2 R 66 2x37 G.H5 D 346 G.H5.22
Hydrophobic TM2 R 66 2x37 G.H5 D 346 G.H5.22
Van-der-waals TM2 R 66 2x37 G.H5 D 346 G.H5.22
Hydrophobic ICL2 P 138 34x50 G.H5 T 336 G.H5.12
Polar C-term S 333 - G.H3 Y 254 G.H3.17
Van-der-waals C-term S 333 - G.H3 Y 254 G.H3.17
Hydrophobic ICL2 R 142 34x54 G.H5 I 339 G.H5.15
Hydrophobic C-term L 337 - G.H2 I 208 G.H2.08
Van-der-waals C-term L 337 - G.H2 I 208 G.H2.08
Polar TM6 K 231 6x25 G.S6 I 315 G.S6.01
Ionic C-term E 348 - G.H2 R 204 G.H2.04
Ionic TM6 H 232 6x26 G.h4s6 E 314 G.h4s6.12
Polar TM6 H 232 6x26 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 H 232 6x26 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 H 232 6x26 G.h4s6 E 314 G.h4s6.12
Hydrophobic C-term F 344 - G.H3 S 248 G.H3.11
Van-der-waals C-term F 344 - G.H3 S 248 G.H3.11
Ionic TM4 D 148 4x40 G.HN K 20 G.HN.48
Polar TM4 D 148 4x40 G.HN K 20 G.HN.48
Van-der-waals TM4 D 148 4x40 G.HN K 20 G.HN.48
Hydrophobic TM2 I 68 2x39 G.H5 C 347 G.H5.23