G12 - GPR17 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 V 253 - G.H5 Q 372 G.H5.17
Hydrophobic TM7 Y 325 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 325 7x53 G.H5 L 380 G.H5.25
Polar H8 E 330 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 330 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 330 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM6 L 257 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM2 N 95 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 95 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 165 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 165 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 168 34x54 G.S1 V 58 G.S1.02
Hydrophobic TM4 P 173 4x39 G.HN R 52 G.HN.52
Hydrophobic ICL3 L 251 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 L 251 - G.H5 L 371 G.H5.16
Hydrophobic TM6 L 257 6x29 G.H5 K 376 G.H5.21
Hydrophobic ICL2 L 168 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 L 98 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 K 169 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 K 169 34x55 G.S3 P 222 G.S3.02
Polar ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 252 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic TM6 M 264 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 264 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 164 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 164 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL3 V 253 - G.H5 L 375 G.H5.20
Hydrophobic H8 F 332 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 161 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 161 3x54 G.H5 L 375 G.H5.20
Polar TM3 A 160 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 160 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 160 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 A 261 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM2 T 92 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 V 165 34x51 G.H5 I 370 G.H5.15
Polar ICL2 R 171 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 171 34x57 G.H5 N 374 G.H5.19
Hydrophobic ICL3 V 253 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 V 253 - G.H5 L 371 G.H5.16
Hydrophobic TM6 A 261 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 261 6x33 G.H5 M 379 G.H5.24
Van-der-waals ICL2 L 168 34x54 G.hns1 R 55 G.hns1.02
Polar H8 E 330 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 E 330 8x48 G.H5 L 380 G.H5.25
Polar TM3 R 157 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 157 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 157 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM4 R 172 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 R 172 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 R 252 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 R 252 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 V 165 34x51 G.H5 K 367 G.H5.12
Polar H8 K 331 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 K 331 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 331 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 260 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 260 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 260 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 161 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 161 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 168 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 V 165 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 L 247 5x65 G.H5 L 375 G.H5.20
Polar ICL2 K 169 34x55 G.s2s3 K 220 G.s2s3.02
Polar ICL1 G 91 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 G 91 - G.hns1 R 55 G.hns1.02
Hydrophobic TM6 L 257 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 L 257 6x29 G.H5 Q 381 G.H5.26
Hydrophobic H8 A 329 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 A 329 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 164 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 K 169 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 165 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL3 L 251 - G.H5 K 367 G.H5.12
Hydrophobic TM3 I 161 3x54 G.H5 I 378 G.H5.23
Hydrophobic H8 K 331 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM3 A 160 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 160 3x53 G.H5 I 378 G.H5.23