G12 - GPR18 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 K 133 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 133 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 133 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 L 222 6x25 G.H5 L 375 G.H5.20
Polar H8 M 301 8x58 G.h4s6 S 343 G.h4s6.12
Ionic ICL2 E 131 34x55 G.HN R 52 G.HN.52
Polar ICL2 E 131 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 E 131 34x55 G.HN R 52 G.HN.52
Van-der-waals ICL2 E 131 34x55 G.HN R 52 G.HN.52
Polar ICL2 K 127 34x51 G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 K 127 34x51 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 K 127 34x51 G.s2s3 K 219 G.s2s3.01
Polar H8 Q 292 8x49 G.H5 K 376 G.H5.21
Hydrophobic H8 Q 292 8x49 G.H5 K 376 G.H5.21
Van-der-waals H8 Q 292 8x49 G.H5 K 376 G.H5.21
Hydrophobic TM2 V 57 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 V 57 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM7 I 288 7x55 G.H5 M 379 G.H5.24
Van-der-waals TM7 I 288 7x55 G.H5 M 379 G.H5.24
Hydrophobic C-term M 310 - G.H4 R 337 G.H4.17
Van-der-waals C-term M 310 - G.H4 R 337 G.H4.17
Hydrophobic TM6 V 226 6x29 G.H5 M 379 G.H5.24
Polar ICL2 K 130 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 130 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 130 34x54 G.hns1 R 56 G.hns1.03
Polar H8 L 302 8x59 G.h4s6 S 343 G.h4s6.12
Hydrophobic H8 L 302 8x59 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 L 302 8x59 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 T 219 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 T 219 - G.H5 L 371 G.H5.16
Polar H8 Q 292 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 Q 292 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 292 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 K 127 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 K 127 34x51 G.S3 I 221 G.S3.01
Polar H8 Y 303 8x60 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 Y 303 8x60 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 S 230 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 S 230 6x33 G.H5 L 375 G.H5.20
Polar H8 I 298 8x55 G.h4s6 S 343 G.h4s6.12
Hydrophobic H8 I 298 8x55 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 I 298 8x55 G.h4s6 S 343 G.h4s6.12
Polar C-term S 309 - G.h4s6 R 342 G.h4s6.11
Van-der-waals C-term S 309 - G.h4s6 R 342 G.h4s6.11
Polar H8 Q 292 8x49 G.H5 L 375 G.H5.20
Hydrophobic H8 Q 292 8x49 G.H5 L 375 G.H5.20
Van-der-waals H8 Q 292 8x49 G.H5 L 375 G.H5.20
Hydrophobic H8 Y 303 8x60 G.h4s6 R 340 G.h4s6.09
Van-der-waals H8 Y 303 8x60 G.h4s6 R 340 G.h4s6.09
Hydrophobic H8 F 293 8x50 G.H5 Q 381 G.H5.26
Van-der-waals H8 F 293 8x50 G.H5 Q 381 G.H5.26
Polar ICL2 E 131 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 E 131 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 131 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic H8 A 295 8x52 G.H5 Q 381 G.H5.26
Van-der-waals H8 A 295 8x52 G.H5 Q 381 G.H5.26
Ionic ICL2 E 131 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 E 131 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 131 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 131 34x55 G.hns1 R 56 G.hns1.03
Polar ICL1 K 52 - G.H3 K 284 G.H3.16
Hydrophobic TM7 V 289 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 V 289 7x56 G.H5 L 380 G.H5.25
Polar H8 R 296 8x53 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 296 8x53 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 296 8x53 G.H5 Q 381 G.H5.26
Polar TM7 V 289 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM7 V 289 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 V 289 7x56 G.H5 M 379 G.H5.24
Hydrophobic H8 Y 303 8x60 G.h3s5 F 287 G.h3s5.01
Ionic H8 R 296 8x53 G.H5 E 373 G.H5.18
Polar H8 R 296 8x53 G.H5 E 373 G.H5.18
Polar C-term L 307 - G.h4s6 R 340 G.h4s6.09
Hydrophobic C-term L 307 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term L 307 - G.h4s6 R 340 G.h4s6.09
Hydrophobic TM2 M 61 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 61 2x43 G.H5 L 380 G.H5.25
Hydrophobic H8 Y 303 8x60 G.h4s6 R 342 G.h4s6.11
Van-der-waals H8 Y 303 8x60 G.h4s6 R 342 G.h4s6.11
Polar ICL2 K 130 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 130 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 130 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 123 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 123 3x54 G.H5 I 378 G.H5.23
Ionic ICL2 K 133 34x57 G.H5 D 377 G.H5.22
Polar ICL2 K 133 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL2 K 133 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 K 133 34x57 G.H5 D 377 G.H5.22
Aromatic ICL2 Y 128 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 128 34x52 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Y 128 34x52 G.hns1 R 56 G.hns1.03
Polar C-term Y 306 - G.h4s6 R 342 G.h4s6.11
Aromatic C-term Y 306 - G.h4s6 R 342 G.h4s6.11
Hydrophobic C-term Y 306 - G.h4s6 R 342 G.h4s6.11
Van-der-waals C-term Y 306 - G.h4s6 R 342 G.h4s6.11
Polar ICL2 K 130 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 K 130 34x54 G.S1 L 57 G.S1.01
Hydrophobic C-term M 310 - G.h4s6 K 338 G.h4s6.01
Hydrophobic TM3 R 119 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 380 G.H5.25
Hydrophobic H8 R 296 8x53 G.H5 K 376 G.H5.21
Polar H8 F 293 8x50 G.H5 L 380 G.H5.25
Polar TM4 N 134 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 N 134 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 N 134 4x38 G.hns1 R 55 G.hns1.02
Polar H8 Q 292 8x49 G.H5 M 379 G.H5.24
Hydrophobic H8 Q 292 8x49 G.H5 M 379 G.H5.24
Van-der-waals H8 Q 292 8x49 G.H5 M 379 G.H5.24
Polar ICL2 K 127 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 127 34x51 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 127 34x51 G.hns1 R 56 G.hns1.03
Polar ICL3 R 218 - G.H5 K 367 G.H5.12
Van-der-waals ICL3 R 218 - G.H5 K 367 G.H5.12
Polar H8 Q 292 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 Q 292 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 292 8x49 G.H5 L 380 G.H5.25
Hydrophobic C-term Y 306 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term Y 306 - G.h4s6 R 340 G.h4s6.09
Hydrophobic H8 V 300 8x57 G.h3s5 F 287 G.h3s5.01
Van-der-waals H8 V 300 8x57 G.h3s5 F 287 G.h3s5.01
Hydrophobic TM7 L 285 7x52 G.H5 L 380 G.H5.25
Hydrophobic TM2 V 57 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 V 57 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM6 V 226 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 V 226 6x29 G.H5 L 375 G.H5.20
Hydrophobic TM2 T 55 2x37 G.H5 D 377 G.H5.22
Polar H8 R 296 8x53 G.h3s5 N 288 G.h3s5.02
Hydrophobic H8 R 296 8x53 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 R 296 8x53 G.h3s5 N 288 G.h3s5.02
Polar C-term Y 306 - G.H4 D 336 G.H4.16
Hydrophobic C-term Y 306 - G.H4 D 336 G.H4.16
Van-der-waals C-term Y 306 - G.H4 D 336 G.H4.16
Polar TM3 A 122 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 374 G.H5.19
Polar H8 V 300 8x57 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 L 222 6x25 G.H5 D 368 G.H5.13
Polar ICL2 K 127 34x51 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 K 127 34x51 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 K 127 34x51 G.s2s3 K 220 G.s2s3.02
Polar H8 S 299 8x56 G.h4s6 K 344 G.h4s6.19
Hydrophobic H8 S 299 8x56 G.h4s6 K 344 G.h4s6.19
Van-der-waals H8 S 299 8x56 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 L 222 6x25 G.H5 L 371 G.H5.16
Hydrophobic H8 Y 303 8x60 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM3 A 122 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 I 378 G.H5.23
Polar H8 L 302 8x59 G.h4s6 R 342 G.h4s6.11
Hydrophobic H8 L 302 8x59 G.h4s6 R 342 G.h4s6.11
Van-der-waals H8 L 302 8x59 G.h4s6 R 342 G.h4s6.11
Polar C-term Y 306 - G.H4 R 337 G.H4.17
Hydrophobic C-term Y 306 - G.H4 R 337 G.H4.17
Van-der-waals C-term Y 306 - G.H4 R 337 G.H4.17
Hydrophobic C-term M 310 - G.h4s6 R 339 G.h4s6.08
Van-der-waals C-term M 310 - G.h4s6 R 339 G.h4s6.08
Hydrophobic TM6 K 221 6x24 G.H5 H 364 G.H5.09
Van-der-waals TM6 K 221 6x24 G.H5 H 364 G.H5.09
Hydrophobic TM3 I 123 3x54 G.H5 L 371 G.H5.16
Polar H8 S 299 8x56 G.h4s6 S 343 G.h4s6.12
Hydrophobic H8 S 299 8x56 G.h4s6 S 343 G.h4s6.12
Van-der-waals H8 S 299 8x56 G.h4s6 S 343 G.h4s6.12
Polar H8 Y 303 8x60 G.h4s6 N 341 G.h4s6.10
Hydrophobic H8 Y 303 8x60 G.h4s6 N 341 G.h4s6.10
Van-der-waals H8 Y 303 8x60 G.h4s6 N 341 G.h4s6.10
Hydrophobic TM6 I 233 6x36 G.H5 M 379 G.H5.24
Hydrophobic C-term Y 306 - G.h4s6 R 339 G.h4s6.08
Van-der-waals C-term Y 306 - G.h4s6 R 339 G.h4s6.08
Hydrophobic C-term Y 306 - G.h4s6 N 341 G.h4s6.10
Van-der-waals C-term Y 306 - G.h4s6 N 341 G.h4s6.10
Polar TM3 R 119 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 I 378 G.H5.23