G12 - GPR19 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Y 249 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 Y 249 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 Y 249 5x64 G.H5 K 367 G.H5.12
Hydrophobic C-term L 402 - G.H2 Q 240 G.H2.09
Van-der-waals C-term L 402 - G.H2 Q 240 G.H2.09
Hydrophobic TM6 T 263 6x22 G.H4 V 332 G.H4.12
Van-der-waals TM6 T 263 6x22 G.H4 V 332 G.H4.12
Polar H8 N 334 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 334 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 334 8x47 G.H5 L 380 G.H5.25
Polar TM5 R 258 5x73 G.H5 H 364 G.H5.09
Hydrophobic TM5 R 258 5x73 G.H5 H 364 G.H5.09
Van-der-waals TM5 R 258 5x73 G.H5 H 364 G.H5.09
Hydrophobic TM5 I 253 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 I 253 5x68 G.H5 L 371 G.H5.16
Polar C-term R 395 - G.H2 Q 236 G.H2.05
Hydrophobic C-term R 395 - G.H2 Q 236 G.H2.05
Van-der-waals C-term R 395 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 K 174 - G.H5 I 370 G.H5.15
Hydrophobic TM3 R 163 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 163 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term I 406 - G.H2 R 235 G.H2.04
Hydrophobic TM2 T 100 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 273 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 167 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 167 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 170 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 170 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 171 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 171 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 171 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL3 R 262 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 T 259 - G.H5 F 361 G.H5.06
Polar TM3 T 166 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 T 166 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 T 166 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL3 R 262 - G.S6 H 348 G.S6.03
Hydrophobic C-term Y 390 - G.S2 V 212 G.S2.02
Hydrophobic TM3 I 167 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term I 389 - H.HA E 92 H.HA.06
Van-der-waals C-term I 389 - H.HA E 92 H.HA.06
Hydrophobic TM6 M 264 6x23 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 M 264 6x23 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 V 260 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 V 260 - G.S6 F 347 G.S6.02
Polar C-term F 393 - G.S2 I 211 G.S2.01
Hydrophobic C-term F 393 - G.S2 I 211 G.S2.01
Van-der-waals C-term F 393 - G.S2 I 211 G.S2.01
Ionic TM6 K 271 6x30 G.H5 D 368 G.H5.13
Polar TM6 K 271 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 K 271 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM5 I 250 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL3 V 260 - G.H5 H 364 G.H5.09
Hydrophobic TM2 N 101 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 101 2x40 G.H5 L 380 G.H5.25
Hydrophobic C-term I 389 - H.HA A 89 H.HA.03
Van-der-waals C-term I 389 - H.HA A 89 H.HA.03
Hydrophobic TM6 T 274 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 274 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 F 278 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 F 278 6x37 G.H5 I 378 G.H5.23
Hydrophobic C-term W 404 - G.H3 T 279 G.H3.11
Hydrophobic C-term F 414 - G.s4h3 E 263 G.s4h3.10
Hydrophobic TM6 K 271 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 K 271 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 171 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 171 34x51 G.S3 I 221 G.S3.01
Polar C-term R 395 - G.H2 Q 240 G.H2.09
Hydrophobic C-term R 395 - G.H2 Q 240 G.H2.09
Van-der-waals C-term R 395 - G.H2 Q 240 G.H2.09
Hydrophobic TM6 T 274 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 274 6x33 G.H5 I 378 G.H5.23
Polar ICL3 R 261 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 R 261 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 R 261 - G.S6 H 348 G.S6.03
Polar TM6 T 263 6x22 G.S6 L 346 G.S6.01
Hydrophobic TM6 T 263 6x22 G.S6 L 346 G.S6.01
Van-der-waals TM6 T 263 6x22 G.S6 L 346 G.S6.01
Ionic TM4 E 178 4x40 G.HN R 52 G.HN.52
Polar TM4 E 178 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 E 178 4x40 G.HN R 52 G.HN.52
Polar TM6 T 263 6x22 G.H4 D 336 G.H4.16
Hydrophobic TM6 T 263 6x22 G.H4 D 336 G.H4.16
Van-der-waals TM6 T 263 6x22 G.H4 D 336 G.H4.16
Aromatic C-term W 404 - G.H2 F 239 G.H2.08
Hydrophobic C-term W 404 - G.H2 F 239 G.H2.08
Van-der-waals C-term W 404 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 L 171 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 171 34x51 G.H5 F 363 G.H5.08
Hydrophobic C-term Y 390 - G.S2 H 214 G.S2.04
Polar C-term N 407 - G.H2 Q 236 G.H2.05
Hydrophobic ICL3 R 262 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 R 262 - G.S6 F 347 G.S6.02
Hydrophobic TM3 T 166 3x53 G.H5 I 378 G.H5.23
Polar H8 N 336 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 336 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 336 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL3 V 260 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 V 260 - G.H5 F 361 G.H5.06
Hydrophobic TM6 T 270 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 270 6x29 G.H5 M 379 G.H5.24
Polar C-term D 387 - H.HA K 88 H.HA.02
Van-der-waals C-term D 387 - H.HA K 88 H.HA.02
Polar ICL2 S 172 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 172 34x52 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 172 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 Y 249 5x64 G.H5 L 371 G.H5.16
Polar TM6 T 263 6x22 G.S6 H 348 G.S6.03
Hydrophobic TM6 T 263 6x22 G.S6 H 348 G.S6.03
Hydrophobic C-term R 395 - G.H2 K 237 G.H2.06
Van-der-waals C-term R 395 - G.H2 K 237 G.H2.06
Hydrophobic ICL3 R 262 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 R 262 - G.S6 L 346 G.S6.01
Polar TM6 T 263 6x22 G.h4s6 R 339 G.h4s6.08
Polar H8 N 336 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 336 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 336 8x49 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 402 - G.H2 F 239 G.H2.08
Van-der-waals C-term L 402 - G.H2 F 239 G.H2.08
Polar C-term I 406 - G.H2 Q 236 G.H2.05
Hydrophobic C-term I 406 - G.H2 Q 236 G.H2.05
Van-der-waals C-term I 406 - G.H2 Q 236 G.H2.05
Polar TM6 T 274 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 K 271 6x30 G.H5 Q 372 G.H5.17
Hydrophobic C-term F 414 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term F 414 - G.s4h3 M 262 G.s4h3.09
Ionic ICL3 R 262 - G.H5 D 368 G.H5.13
Polar ICL3 R 262 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 262 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 262 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 262 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 170 34x50 G.H5 L 371 G.H5.16
Hydrophobic C-term A 403 - G.H2 F 239 G.H2.08
Van-der-waals C-term A 403 - G.H2 F 239 G.H2.08
Polar C-term N 412 - G.H2 S 233 G.H2.02
Polar ICL2 P 170 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 171 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 I 167 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 170 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 170 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 171 34x51 G.H5 K 367 G.H5.12