GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | T | 263 | 6x22 | G.S6 | S | 321 | G.S6.03 |
Hydrophobic | TM6 | T | 263 | 6x22 | G.S6 | S | 321 | G.S6.03 |
Van-der-waals | TM6 | T | 263 | 6x22 | G.S6 | S | 321 | G.S6.03 |
Hydrophobic | C-term | K | 398 | - | G.hgh4 | P | 288 | G.hgh4.03 |
Van-der-waals | C-term | K | 398 | - | G.hgh4 | P | 288 | G.hgh4.03 |
Hydrophobic | C-term | A | 367 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Van-der-waals | C-term | A | 367 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Aromatic | C-term | Y | 390 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | C-term | Y | 390 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | Y | 390 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | TM6 | I | 275 | 6x34 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | V | 260 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | V | 260 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | TM6 | M | 277 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 277 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | V | 260 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | L | 402 | - | G.HG | H | 282 | G.HG.14 |
Hydrophobic | C-term | A | 403 | - | G.H4 | N | 294 | G.H4.01 |
Van-der-waals | C-term | A | 403 | - | G.H4 | N | 294 | G.H4.01 |
Polar | C-term | N | 370 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | N | 370 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | N | 370 | - | G.H3 | H | 248 | G.H3.07 |
Polar | C-term | K | 401 | - | G.HG | H | 282 | G.HG.14 |
Hydrophobic | C-term | K | 401 | - | G.HG | H | 282 | G.HG.14 |
Van-der-waals | C-term | K | 401 | - | G.HG | H | 282 | G.HG.14 |
Hydrophobic | C-term | F | 393 | - | G.HG | I | 285 | G.HG.17 |
Van-der-waals | C-term | F | 393 | - | G.HG | I | 285 | G.HG.17 |
Hydrophobic | C-term | I | 374 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | I | 374 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM6 | K | 271 | 6x30 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | K | 271 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | K | 271 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Polar | TM2 | T | 100 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 100 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Polar | TM2 | T | 100 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | T | 100 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | E | 399 | - | G.HG | I | 285 | G.HG.17 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM6 | F | 278 | 6x37 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | F | 278 | 6x37 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | I | 167 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 167 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | V | 372 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | V | 372 | - | G.H3 | H | 248 | G.H3.07 |
Polar | C-term | R | 395 | - | G.s4h3 | D | 231 | G.s4h3.05 |
Van-der-waals | C-term | R | 395 | - | G.s4h3 | D | 231 | G.s4h3.05 |
Hydrophobic | TM6 | K | 271 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | K | 271 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | P | 268 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | P | 268 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM1 | V | 89 | 1x56 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM1 | V | 89 | 1x56 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | W | 404 | - | G.HG | K | 279 | G.HG.09 |
Van-der-waals | C-term | W | 404 | - | G.HG | K | 279 | G.HG.09 |
Hydrophobic | TM6 | M | 264 | 6x23 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | M | 264 | 6x23 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL3 | T | 259 | - | G.H5 | F | 334 | G.H5.06 |
Ionic | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | S | 363 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Van-der-waals | C-term | S | 363 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Polar | C-term | F | 393 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | C-term | F | 393 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | F | 393 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Polar | H8 | N | 336 | 8x49 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | H8 | N | 336 | 8x49 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | N | 336 | 8x49 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | K | 398 | - | G.HG | I | 285 | G.HG.17 |
Van-der-waals | C-term | K | 398 | - | G.HG | I | 285 | G.HG.17 |
Hydrophobic | TM6 | T | 274 | 6x33 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 274 | 6x33 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | A | 403 | - | G.HG | K | 280 | G.HG.12 |
Hydrophobic | C-term | A | 403 | - | G.HG | K | 280 | G.HG.12 |
Polar | ICL2 | K | 174 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | K | 174 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 174 | - | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | K | 174 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | K | 174 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM7 | Y | 330 | 7x53 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM7 | Y | 330 | 7x53 | G.H5 | L | 353 | G.H5.25 |
Ionic | C-term | E | 376 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | E | 376 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | TM1 | S | 93 | 1x60 | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | N | 265 | 6x24 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | N | 265 | 6x24 | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | TM2 | S | 98 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | S | 98 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | C-term | F | 393 | - | G.hgh4 | C | 286 | G.hgh4.01 |
Polar | TM2 | N | 101 | 2x40 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM2 | N | 101 | 2x40 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM2 | N | 101 | 2x40 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | T | 263 | 6x22 | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | TM6 | T | 263 | 6x22 | G.H4 | K | 304 | G.H4.12 |
Ionic | TM6 | K | 271 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | K | 271 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | K | 271 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Polar | TM3 | R | 163 | 3x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | I | 253 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Polar | TM3 | R | 163 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 163 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 163 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | F | 393 | - | G.s4h3 | V | 233 | G.s4h3.07 |
Hydrophobic | ICL3 | V | 260 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | C-term | L | 402 | - | G.HG | K | 280 | G.HG.12 |
Van-der-waals | C-term | L | 402 | - | G.HG | K | 280 | G.HG.12 |
Polar | H8 | N | 334 | 8x47 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | H8 | N | 334 | 8x47 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | H8 | N | 334 | 8x47 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM5 | R | 258 | 5x73 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | R | 258 | 5x73 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | R | 258 | 5x73 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | R | 258 | 5x73 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | K | 401 | - | G.HG | S | 284 | G.HG.16 |
Van-der-waals | C-term | K | 401 | - | G.HG | S | 284 | G.HG.16 |
Hydrophobic | TM2 | V | 104 | 2x43 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | V | 104 | 2x43 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | V | 260 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | C-term | A | 403 | - | G.HG | V | 281 | G.HG.13 |
Hydrophobic | TM6 | T | 263 | 6x22 | G.H4 | L | 308 | G.H4.16 |
Van-der-waals | TM6 | T | 263 | 6x22 | G.H4 | L | 308 | G.H4.16 |
Hydrophobic | C-term | A | 403 | - | G.HG | H | 282 | G.HG.14 |
Polar | TM6 | T | 274 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | T | 274 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | P | 170 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM1 | I | 90 | 1x57 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM1 | I | 90 | 1x57 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | Y | 390 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | F | 393 | - | G.s4h3 | N | 241 | G.s4h3.15 |
Van-der-waals | C-term | F | 393 | - | G.s4h3 | N | 241 | G.s4h3.15 |
Polar | ICL3 | R | 261 | - | G.S6 | S | 321 | G.S6.03 |
Van-der-waals | ICL3 | R | 261 | - | G.S6 | S | 321 | G.S6.03 |
Hydrophobic | C-term | R | 395 | - | H.HD | E | 145 | H.HD.12 |
Van-der-waals | C-term | R | 395 | - | H.HD | E | 145 | H.HD.12 |
Hydrophobic | TM6 | T | 274 | 6x33 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | T | 274 | 6x33 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | V | 372 | - | G.H3 | S | 252 | G.H3.11 |
Polar | ICL2 | S | 172 | 34x52 | G.hns1 | K | 32 | G.hns1.03 |
Aromatic | H8 | F | 337 | 8x50 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | H8 | F | 337 | 8x50 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | F | 337 | 8x50 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | Y | 249 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | P | 170 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 170 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | P | 268 | 6x27 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | P | 268 | 6x27 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL2 | P | 170 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | R | 395 | - | H.HD | A | 144 | H.HD.11 |
Hydrophobic | C-term | R | 395 | - | H.HD | A | 144 | H.HD.11 |
Van-der-waals | C-term | R | 395 | - | H.HD | A | 144 | H.HD.11 |
Polar | TM2 | T | 100 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 100 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | T | 100 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | T | 263 | 6x22 | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | TM6 | T | 263 | 6x22 | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL2 | P | 170 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 170 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM3 | T | 166 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | T | 166 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | T | 166 | 3x53 | G.H5 | N | 347 | G.H5.19 |