GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 148 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 148 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 148 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | M | 328 | - | G.H2 | I | 220 | G.H2.08 |
Polar | H8 | S | 302 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | S | 302 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | A | 239 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | A | 239 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | L | 229 | 6x23 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | L | 229 | 6x23 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM3 | D | 147 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | D | 147 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | D | 147 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | E | 156 | 34x51 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | ICL2 | P | 155 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 155 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | R | 235 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | R | 235 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | L | 229 | 6x23 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | L | 229 | 6x23 | G.H5 | L | 368 | G.H5.20 |
Polar | TM4 | Q | 163 | 4x38 | G.HN | K | 37 | G.HN.52 |
Polar | H8 | G | 303 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | G | 303 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | H | 230 | 6x24 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM4 | P | 164 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM4 | Q | 163 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM2 | T | 86 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | T | 86 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM6 | Q | 231 | 6x25 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | Q | 231 | 6x25 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | I | 152 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | I | 152 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | R | 159 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | R | 159 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL2 | R | 159 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | R | 159 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM6 | L | 243 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 352 | - | G.H3 | T | 260 | G.H3.11 |
Polar | ICL2 | E | 156 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | E | 156 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM2 | S | 88 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | S | 88 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | R | 159 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | R | 159 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM6 | H | 230 | 6x24 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM3 | I | 152 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Polar | TM6 | Q | 231 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | Q | 231 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 231 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | L | 352 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM6 | L | 229 | 6x23 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM6 | L | 229 | 6x23 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | R | 159 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 159 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Hydrophobic | C-term | L | 352 | - | G.H3 | I | 261 | G.H3.12 |
Hydrophobic | C-term | L | 352 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | ICL2 | E | 156 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | E | 156 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | T | 349 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | L | 348 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | L | 348 | - | G.H3 | L | 264 | G.H3.15 |
Ionic | TM6 | H | 230 | 6x24 | G.H5 | D | 361 | G.H5.13 |
Polar | TM6 | H | 230 | 6x24 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM6 | H | 230 | 6x24 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | A | 353 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | T | 349 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | T | 349 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | ICL3 | L | 228 | - | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | ICL3 | L | 228 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | I | 152 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 152 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | R | 235 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 235 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | P | 356 | - | G.H3 | A | 256 | G.H3.07 |
Polar | C-term | L | 352 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | L | 352 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | L | 352 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | A | 353 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | A | 353 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | A | 353 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | TM3 | A | 151 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 151 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 148 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Polar | H8 | S | 302 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | S | 302 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | T | 301 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | R | 162 | 34x57 | G.H5 | Y | 367 | G.H5.19 |
Aromatic | ICL2 | R | 162 | 34x57 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 162 | 34x57 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 162 | 34x57 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | L | 352 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | C-term | L | 352 | - | G.H3 | L | 257 | G.H3.08 |
Polar | H8 | T | 301 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | T | 301 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | T | 301 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | A | 351 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM3 | I | 152 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | L | 348 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM6 | L | 242 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | L | 242 | 6x36 | G.H5 | L | 373 | G.H5.25 |