Gs - GPR20 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ICL3 L 228 - G.H5 D 381 G.H5.13
Polar TM3 I 152 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 152 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 152 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 R 159 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 R 159 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 159 34x54 G.hns1 A 39 G.hns1.03
Polar H8 G 303 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 G 303 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL3 L 228 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 L 228 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 155 34x50 G.H5 I 383 G.H5.15
Ionic ICL2 E 156 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 E 156 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 E 156 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM6 R 235 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 235 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM4 P 164 4x39 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 P 164 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic C-term L 352 - G.H3 S 275 G.H3.11
Polar TM3 A 151 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 151 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 H 387 G.H5.19
Hydrophobic C-term M 328 - G.H3 W 281 G.H3.17
Polar ICL2 R 159 34x54 G.S1 T 40 G.S1.01
Hydrophobic TM6 L 243 6x37 G.H5 L 393 G.H5.25
Van-der-waals C-term R 330 - G.HN K 34 G.HN.51
Hydrophobic ICL2 P 155 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 155 34x50 G.H5 Q 384 G.H5.16
Polar TM4 Q 163 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 Q 163 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 Q 163 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 E 156 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 E 156 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM6 Q 231 6x25 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 231 6x25 G.H5 R 385 G.H5.17
Hydrophobic C-term V 325 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term V 325 - G.h3s5 T 284 G.h3s5.02
Ionic C-term H 329 - G.h2s4 D 240 G.h2s4.03
Polar C-term H 329 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term H 329 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term H 329 - G.h2s4 D 240 G.h2s4.03
Polar ICL2 R 162 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 162 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 162 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 162 34x57 G.H5 H 387 G.H5.19
Polar ICL2 R 159 34x54 G.S1 H 41 G.S1.02
Aromatic ICL2 R 159 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 159 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 159 34x54 G.S1 H 41 G.S1.02
Polar TM6 R 235 6x29 G.h4s6 Y 358 G.h4s6.20
Polar TM3 D 147 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 147 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 147 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 242 6x36 G.H5 L 393 G.H5.25
Polar TM3 R 148 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 Y 391 G.H5.23
Hydrophobic C-term L 348 - G.H2 R 232 G.H2.05
Polar H8 T 301 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 T 301 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 301 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 393 G.H5.25
Polar TM2 T 86 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 T 86 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 T 86 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 229 6x23 G.H5 L 388 G.H5.20
Hydrophobic TM6 Q 231 6x25 G.H5 L 394 G.H5.26
Van-der-waals TM6 Q 231 6x25 G.H5 L 394 G.H5.26
Hydrophobic TM3 A 151 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 151 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 229 6x23 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 229 6x23 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 152 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 152 3x54 G.H5 L 388 G.H5.20
Polar ICL2 R 159 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 H 230 6x24 G.H5 R 385 G.H5.17
Van-der-waals TM6 H 230 6x24 G.H5 R 385 G.H5.17
Hydrophobic ICL2 E 156 34x51 G.S3 V 217 G.S3.01
Hydrophobic C-term L 352 - G.H3 N 279 G.H3.15
Van-der-waals C-term L 352 - G.H3 N 279 G.H3.15
Hydrophobic TM5 L 223 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 223 5x65 G.H5 L 388 G.H5.20
Polar TM6 Q 231 6x25 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 Q 231 6x25 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 Q 231 6x25 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 R 159 34x54 G.H5 I 383 G.H5.15
Van-der-waals ICL2 R 159 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 155 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 155 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM2 S 88 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 88 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 152 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 152 3x54 G.H5 L 393 G.H5.25
Ionic C-term E 319 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 319 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 319 - G.h4s6 R 356 G.h4s6.12
Polar H8 S 302 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 S 302 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 302 8x48 G.H5 E 392 G.H5.24
Polar C-term H 329 - G.hns1 Y 37 G.hns1.01
Hydrophobic C-term H 329 - G.hns1 Y 37 G.hns1.01
Van-der-waals C-term H 329 - G.hns1 Y 37 G.hns1.01
Polar ICL2 R 162 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 162 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 L 228 - G.H5 L 388 G.H5.20
Polar C-term H 329 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term H 329 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term H 329 - G.h2s4 N 239 G.h2s4.02