Gs - GPR21 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 N 138 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 138 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 138 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 134 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 I 225 5x73 G.H5 L 394 G.H5.26
Hydrophobic TM6 Y 250 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 Y 250 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 T 136 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 136 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 N 138 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 H 221 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 225 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 225 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM7 S 307 7x56 G.H5 E 392 G.H5.24
Polar TM3 A 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 217 5x65 G.H5 Q 384 G.H5.16
Polar TM5 R 228 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 228 5x76 G.S6 C 359 G.S6.01
Polar TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 130 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 135 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 135 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 135 34x51 G.H5 I 383 G.H5.15
Polar TM5 C 218 5x66 G.H5 L 393 G.H5.25
Hydrophobic TM5 C 218 5x66 G.H5 L 393 G.H5.25
Van-der-waals TM5 C 218 5x66 G.H5 L 393 G.H5.25
Hydrophobic H8 N 308 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 131 3x54 G.H5 H 387 G.H5.19
Polar TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 135 34x51 G.S3 V 217 G.S3.01
Polar ICL1 H 61 - G.HN K 34 G.HN.51
Hydrophobic ICL1 H 61 - G.HN K 34 G.HN.51
Polar TM2 T 64 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 R 231 5x79 G.H4 R 342 G.H4.12
Van-der-waals TM5 R 231 5x79 G.H4 R 342 G.H4.12
Hydrophobic TM5 R 231 5x79 G.hgh4 P 321 G.hgh4.11
Van-der-waals TM5 R 231 5x79 G.hgh4 P 321 G.hgh4.11
Hydrophobic TM5 F 232 5x80 G.H4 L 346 G.H4.16
Van-der-waals TM5 F 232 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM5 F 232 5x80 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 F 232 5x80 G.h4s6 T 350 G.h4s6.03
Aromatic ICL2 Y 137 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 137 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 225 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 214 5x62 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 214 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM4 P 143 4x39 G.HN Q 35 G.HN.52
Hydrophobic TM6 L 254 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 254 6x37 G.H5 L 393 G.H5.25
Polar H8 S 309 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 S 309 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 309 8x48 G.H5 E 392 G.H5.24
Ionic TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Polar TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Aromatic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 135 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 135 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM6 V 253 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 253 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM4 T 142 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 142 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 I 217 5x65 G.H5 L 388 G.H5.20
Ionic TM5 R 231 5x79 G.H4 D 343 G.H4.13
Polar TM5 R 231 5x79 G.H4 D 343 G.H4.13
Hydrophobic TM5 F 232 5x80 G.H4 D 343 G.H4.13
Polar ICL2 L 135 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 135 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 135 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 134 34x50 G.H5 H 387 G.H5.19
Polar ICL1 H 61 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 H 61 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 H 61 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 131 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 135 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 T 139 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 139 34x55 G.hns1 A 39 G.hns1.03
Ionic TM5 H 221 5x69 G.H5 D 381 G.H5.13
Polar TM5 H 221 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 221 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 221 5x69 G.H5 D 381 G.H5.13
Hydrophobic ICL2 P 134 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 C 218 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 C 218 5x66 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 134 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 134 34x50 G.H5 R 380 G.H5.12
Polar TM2 H 62 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 H 62 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 H 62 2x37 G.H5 Q 390 G.H5.22
Ionic TM6 R 249 6x32 G.H5 E 392 G.H5.24
Polar TM6 R 249 6x32 G.H5 E 392 G.H5.24
Polar TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 L 388 G.H5.20
Polar H8 N 308 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 308 8x47 G.H5 Q 390 G.H5.22