Gi3 - GPR22 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 78.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 Q 250 - G.H4 E 298 G.H4.05
Hydrophobic ICL3 Q 250 - G.H4 E 298 G.H4.05
Polar TM6 R 310 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 310 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 310 6x32 G.H5 Y 354 G.H5.26
Polar ICL2 N 149 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 N 149 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 149 34x52 G.s2s3 D 193 G.s2s3.02
Ionic H8 K 373 8x49 G.H5 E 350 G.H5.22
Polar H8 K 373 8x49 G.H5 E 350 G.H5.22
Hydrophobic H8 K 373 8x49 G.H5 E 350 G.H5.22
Van-der-waals H8 K 373 8x49 G.H5 E 350 G.H5.22
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Ionic H8 K 376 8x52 G.h3s5 E 261 G.h3s5.02
Polar H8 K 376 8x52 G.h3s5 E 261 G.h3s5.02
Van-der-waals H8 K 376 8x52 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM5 F 246 5x73 G.S6 T 321 G.S6.03
Polar ICL3 R 296 - G.H4 C 305 G.H4.13
Hydrophobic ICL3 R 296 - G.H4 C 305 G.H4.13
Van-der-waals ICL3 R 296 - G.H4 C 305 G.H4.13
Ionic ICL3 R 296 - G.H4 E 308 G.H4.16
Polar ICL3 R 296 - G.H4 E 308 G.H4.16
Polar TM6 R 307 6x29 G.h4s6 D 315 G.h4s6.09
Ionic ICL3 R 296 - G.H4 D 309 G.H4.17
Polar ICL3 R 296 - G.H4 D 309 G.H4.17
Hydrophobic ICL3 R 296 - G.H4 D 309 G.H4.17
Van-der-waals ICL3 R 296 - G.H4 D 309 G.H4.17
Hydrophobic TM4 T 153 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 153 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.16
Hydrophobic H8 R 371 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 M 314 6x36 G.H5 L 353 G.H5.25
Ionic ICL3 K 299 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 V 311 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 234 5x61 G.H5 L 348 G.H5.20
Polar ICL2 R 150 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 150 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 242 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 242 5x69 G.H5 D 341 G.H5.13
Polar TM4 M 154 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 M 154 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 M 154 4x39 G.HN E 28 G.HN.52
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 241 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 K 253 - G.H4 A 301 G.H4.08
Polar TM4 M 154 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 M 154 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 M 154 4x39 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 147 34x50 G.H5 T 340 G.H5.12
Hydrophobic H8 R 371 8x47 G.H5 C 351 G.H5.23
Van-der-waals TM4 V 158 4x43 G.HN R 24 G.HN.48
Polar ICL3 R 300 - G.S6 I 319 G.S6.01
Hydrophobic TM5 R 245 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 R 245 5x72 G.H5 F 334 G.H5.06
Ionic TM6 R 307 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 307 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 307 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term I 401 - G.H3 W 258 G.H3.17
Van-der-waals C-term I 401 - G.H3 W 258 G.H3.17
Hydrophobic TM6 V 311 6x33 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 A 148 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 A 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 S 144 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 S 144 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 R 371 8x47 G.H5 E 350 G.H5.22
Van-der-waals H8 R 371 8x47 G.H5 E 350 G.H5.22
Hydrophobic TM5 Y 231 5x58 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 148 34x51 G.s2s3 D 193 G.s2s3.02
Polar TM6 R 307 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 307 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 307 6x29 G.H5 Y 354 G.H5.26
Polar H8 Q 372 8x48 G.H5 K 349 G.H5.21
Polar TM5 R 245 5x72 G.H5 Q 333 G.H5.05
Hydrophobic TM5 R 245 5x72 G.H5 Q 333 G.H5.05
Van-der-waals TM5 R 245 5x72 G.H5 Q 333 G.H5.05
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 R 307 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 307 6x29 G.H5 K 345 G.H5.17
Hydrophobic C-term W 405 - G.H3 L 249 G.H3.08
Van-der-waals C-term W 405 - G.H3 L 249 G.H3.08
Polar TM7 T 370 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 370 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 370 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 S 144 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 S 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 238 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 318 6x40 G.H5 L 353 G.H5.25
Ionic TM5 R 245 5x72 G.H5 D 337 G.H5.09
Polar TM5 R 245 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 245 5x72 G.H5 D 337 G.H5.09
Hydrophobic C-term W 405 - G.H3 K 248 G.H3.07
Van-der-waals C-term W 405 - G.H3 K 248 G.H3.07
Polar TM5 R 245 5x72 G.H5 K 330 G.H5.02
Hydrophobic C-term W 405 - G.H3 D 251 G.H3.10
Polar TM3 I 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 F 246 5x73 G.S6 Y 320 G.S6.02
Ionic ICL3 R 300 - G.H4 E 308 G.H4.16
Polar ICL3 R 300 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 R 300 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 R 300 - G.H4 E 308 G.H4.16
Polar TM6 V 311 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 311 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 311 6x33 G.H5 L 353 G.H5.25
Polar C-term W 405 - G.H3 S 252 G.H3.11
Hydrophobic C-term W 405 - G.H3 S 252 G.H3.11
Van-der-waals C-term W 405 - G.H3 S 252 G.H3.11
Hydrophobic TM5 R 241 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 241 5x68 G.H5 T 340 G.H5.12
Hydrophobic C-term I 406 - G.H2 K 209 G.H2.05
Van-der-waals C-term I 406 - G.H2 K 209 G.H2.05