Gs - GPR22 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 75.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 143 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 143 3x53 G.H5 Y 391 G.H5.23
Polar TM6 V 311 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 311 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 311 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 R 300 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 R 300 - G.H4 L 346 G.H4.16
Hydrophobic TM3 S 144 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 S 144 3x54 G.H5 L 388 G.H5.20
Polar TM2 N 74 2x36 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 N 74 2x36 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 N 74 2x36 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 R 307 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 307 6x29 G.H5 L 394 G.H5.26
Polar ICL2 R 150 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 R 296 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 R 296 - G.H4 R 347 G.H4.17
Polar ICL3 R 300 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 R 300 - G.S6 C 359 G.S6.01
Polar ICL2 N 149 34x52 G.s2s3 K 216 G.s2s3.02
Polar ICL3 K 253 - G.hgh4 Y 318 G.hgh4.08
Van-der-waals ICL3 K 253 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic H8 R 371 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 R 371 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 147 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM6 R 307 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 307 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 238 5x65 G.H5 Q 384 G.H5.16
Hydrophobic C-term I 406 - G.H2 R 232 G.H2.05
Hydrophobic ICL3 G 249 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 G 249 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 K 253 - G.hgh4 T 319 G.hgh4.09
Polar ICL3 T 248 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 T 248 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 T 248 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM5 F 246 5x73 G.S6 P 361 G.S6.03
Van-der-waals TM5 F 246 5x73 G.S6 P 361 G.S6.03
Hydrophobic C-term I 401 - G.H3 W 281 G.H3.17
Hydrophobic C-term W 405 - G.H3 N 278 G.H3.14
Polar TM3 I 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 143 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 143 3x53 G.H5 H 387 G.H5.19
Hydrophobic C-term W 405 - G.H3 S 275 G.H3.11
Van-der-waals C-term W 405 - G.H3 S 275 G.H3.11
Hydrophobic ICL2 P 147 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 147 34x50 G.H5 Q 384 G.H5.16
Polar ICL2 P 147 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 147 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 147 34x50 G.H5 H 387 G.H5.19
Polar TM2 S 75 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 75 2x37 G.H5 Y 391 G.H5.23
Hydrophobic C-term I 401 - G.H3 R 280 G.H3.16
Van-der-waals C-term I 401 - G.H3 R 280 G.H3.16
Polar TM5 S 247 5x74 G.hgh4 A 324 G.hgh4.14
Hydrophobic TM5 S 247 5x74 G.hgh4 A 324 G.hgh4.14
Van-der-waals TM5 S 247 5x74 G.hgh4 A 324 G.hgh4.14
Hydrophobic ICL2 A 148 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 A 148 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM6 R 310 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 310 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 147 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 R 140 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 140 3x50 G.H5 L 393 G.H5.25
Polar TM5 S 247 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 S 247 5x74 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 S 247 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 F 246 5x73 G.H4 R 342 G.H4.12
Polar TM6 R 307 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 R 307 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 307 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic C-term W 405 - G.H3 N 279 G.H3.15
Van-der-waals C-term W 405 - G.H3 N 279 G.H3.15
Polar ICL3 R 296 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 R 296 - G.H4 L 346 G.H4.16
Polar ICL3 R 296 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 R 296 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 R 296 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM2 S 77 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 77 2x39 G.H5 Y 391 G.H5.23
Hydrophobic C-term F 416 - G.H2 R 232 G.H2.05
Van-der-waals C-term F 416 - G.H2 R 232 G.H2.05
Hydrophobic ICL3 G 249 - G.hgh4 P 321 G.hgh4.11
Polar H8 K 373 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 K 373 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 373 8x49 G.H5 Q 390 G.H5.22
Polar TM3 S 144 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 S 144 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 S 144 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 G 249 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 G 249 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM5 R 241 5x68 G.H5 R 380 G.H5.12
Van-der-waals TM5 R 241 5x68 G.H5 R 380 G.H5.12
Hydrophobic TM5 L 238 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 238 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 148 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 A 148 34x51 G.S1 H 41 G.S1.02
Aromatic ICL2 R 150 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 150 34x53 G.H5 H 387 G.H5.19
Polar ICL3 T 248 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 T 248 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 T 248 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 F 246 5x73 G.H4 L 346 G.H4.16
Polar ICL3 Q 250 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 Q 250 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 Q 250 - G.hgh4 E 322 G.hgh4.12
Polar TM5 S 247 5x74 G.hgh4 T 325 G.hgh4.15
Hydrophobic TM5 S 247 5x74 G.hgh4 T 325 G.hgh4.15
Van-der-waals TM5 S 247 5x74 G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 K 253 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 K 253 - G.hgh4 P 321 G.hgh4.11
Hydrophobic TM5 F 246 5x73 G.hgh4 D 323 G.hgh4.13
Polar H8 R 371 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 R 371 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 R 371 8x47 G.H5 E 392 G.H5.24
Polar H8 Q 372 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 372 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 372 8x48 G.H5 E 392 G.H5.24
Ionic ICL3 K 253 - G.H4 D 343 G.H4.13
Polar ICL3 K 253 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 K 253 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 K 253 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 A 148 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM7 T 370 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 T 370 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 N 149 34x52 G.S3 V 217 G.S3.01