Gs - GPR27 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 E 275 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 E 275 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 E 275 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 R 128 34x51 G.h3s5 I 285 G.h3s5.03
Van-der-waals ICL2 R 128 34x51 G.h3s5 I 285 G.h3s5.03
Polar ICL3 R 269 - G.S6 P 361 G.S6.03
Hydrophobic ICL3 R 269 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 R 269 - G.S6 P 361 G.S6.03
Polar TM3 I 124 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 124 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 124 3x54 G.H5 L 393 G.H5.25
Polar TM5 R 211 5x72 G.H5 H 387 G.H5.19
Hydrophobic TM5 R 211 5x72 G.H5 H 387 G.H5.19
Van-der-waals TM5 R 211 5x72 G.H5 H 387 G.H5.19
Hydrophobic TM5 F 207 5x68 G.H5 L 393 G.H5.25
Van-der-waals TM5 F 207 5x68 G.H5 L 393 G.H5.25
Polar TM5 R 215 5x76 G.H5 R 380 G.H5.12
Hydrophobic TM5 R 215 5x76 G.H5 R 380 G.H5.12
Van-der-waals TM5 R 215 5x76 G.H5 R 380 G.H5.12
Polar ICL3 R 269 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 R 269 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 R 269 - G.S6 Y 360 G.S6.02
Hydrophobic TM5 M 214 5x75 G.S1 H 41 G.S1.02
Van-der-waals TM5 M 214 5x75 G.S1 H 41 G.S1.02
Hydrophobic TM5 R 211 5x72 G.S1 H 41 G.S1.02
Polar ICL3 R 268 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 R 268 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 R 268 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 H 127 34x50 G.H5 L 394 G.H5.26
Van-der-waals ICL2 H 127 34x50 G.H5 L 394 G.H5.26
Polar ICL2 H 127 34x50 G.H5 R 389 G.H5.21
Hydrophobic ICL2 H 127 34x50 G.H5 R 389 G.H5.21
Van-der-waals ICL2 H 127 34x50 G.H5 R 389 G.H5.21
Hydrophobic ICL3 L 219 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 L 219 - G.H5 D 381 G.H5.13
Hydrophobic TM5 K 213 5x74 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM3 A 125 3x55 G.H5 E 392 G.H5.24
Van-der-waals TM3 A 125 3x55 G.H5 E 392 G.H5.24
Hydrophobic ICL3 V 272 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 V 272 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 A 217 - G.H5 N 377 G.H5.09
Van-der-waals ICL3 A 217 - G.H5 N 377 G.H5.09
Ionic ICL3 R 269 - G.H5 D 378 G.H5.10
Polar ICL3 R 269 - G.H5 D 378 G.H5.10
Van-der-waals ICL3 R 269 - G.H5 D 378 G.H5.10
Polar ICL2 R 128 34x51 G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 R 128 34x51 G.h3s5 T 284 G.h3s5.02
Van-der-waals ICL2 R 128 34x51 G.h3s5 T 284 G.h3s5.02
Polar TM3 A 123 3x53 G.H5 L 394 G.H5.26
Hydrophobic TM3 A 123 3x53 G.H5 L 394 G.H5.26
Van-der-waals TM3 A 123 3x53 G.H5 L 394 G.H5.26
Polar TM5 M 214 5x75 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM5 M 214 5x75 G.s2s3 D 215 G.s2s3.01
Van-der-waals TM5 M 214 5x75 G.s2s3 D 215 G.s2s3.01
Polar TM5 R 215 5x76 G.s2s3 D 215 G.s2s3.01
Polar ICL2 F 129 34x52 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 129 34x52 G.H5 E 392 G.H5.24
Van-der-waals ICL2 F 129 34x52 G.H5 E 392 G.H5.24
Hydrophobic TM5 R 211 5x72 G.H5 L 388 G.H5.20
Van-der-waals TM5 R 211 5x72 G.H5 L 388 G.H5.20
Polar ICL2 R 128 34x51 G.H5 R 389 G.H5.21
Hydrophobic TM6 E 279 6x30 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 273 6x24 G.H5 I 382 G.H5.14
Ionic TM3 H 126 3x56 G.H5 E 392 G.H5.24
Polar TM3 H 126 3x56 G.H5 E 392 G.H5.24
Hydrophobic TM3 H 126 3x56 G.H5 E 392 G.H5.24
Van-der-waals TM3 H 126 3x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 K 213 5x74 G.s2s3 D 215 G.s2s3.01
Van-der-waals TM5 K 213 5x74 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM6 L 273 6x24 G.S6 Y 360 G.S6.02
Polar ICL3 R 268 - G.h4s6 S 349 G.h4s6.02
Van-der-waals ICL3 R 268 - G.h4s6 S 349 G.h4s6.02
Hydrophobic ICL3 V 272 - G.H5 R 389 G.H5.21
Van-der-waals ICL3 V 272 - G.H5 R 389 G.H5.21
Hydrophobic TM5 M 214 5x75 G.S3 V 217 G.S3.01
Van-der-waals TM5 M 214 5x75 G.S3 V 217 G.S3.01
Hydrophobic ICL3 L 271 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 R 128 34x51 G.H5 E 392 G.H5.24
Van-der-waals ICL2 R 128 34x51 G.H5 E 392 G.H5.24
Hydrophobic ICL3 R 268 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 211 5x72 G.H5 L 393 G.H5.25
Van-der-waals TM5 R 211 5x72 G.H5 L 393 G.H5.25
Hydrophobic ICL3 R 269 - G.H5 I 382 G.H5.14
Van-der-waals ICL3 R 269 - G.H5 I 382 G.H5.14
Hydrophobic TM3 H 126 3x56 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 M 214 5x75 G.S3 F 219 G.S3.03
Van-der-waals TM5 M 214 5x75 G.S3 F 219 G.S3.03
Aromatic TM6 F 276 6x27 G.H5 R 385 G.H5.17
Hydrophobic TM6 F 276 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 F 276 6x27 G.H5 R 385 G.H5.17
Hydrophobic ICL2 R 128 34x51 G.H5 Q 390 G.H5.22
Hydrophobic TM5 M 214 5x75 G.H5 R 380 G.H5.12
Van-der-waals TM5 M 214 5x75 G.H5 R 380 G.H5.12
Hydrophobic TM6 F 276 6x27 G.H5 L 394 G.H5.26
Van-der-waals TM6 F 276 6x27 G.H5 L 394 G.H5.26
Hydrophobic TM5 F 207 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 F 207 5x68 G.H5 L 388 G.H5.20
Polar TM3 I 124 3x54 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 124 3x54 G.H5 L 394 G.H5.26
Van-der-waals TM3 I 124 3x54 G.H5 L 394 G.H5.26
Hydrophobic TM6 F 276 6x27 G.H5 L 388 G.H5.20
Van-der-waals TM6 F 276 6x27 G.H5 L 388 G.H5.20
Polar TM5 R 211 5x72 G.hns1 R 38 G.hns1.02
Van-der-waals TM5 R 211 5x72 G.hns1 R 38 G.hns1.02
Ionic TM6 E 275 6x26 G.H5 R 389 G.H5.21
Polar TM6 E 275 6x26 G.H5 R 389 G.H5.21
Hydrophobic TM6 E 275 6x26 G.H5 R 389 G.H5.21
Van-der-waals TM6 E 275 6x26 G.H5 R 389 G.H5.21
Hydrophobic ICL3 L 219 - G.H5 D 378 G.H5.10
Van-der-waals ICL3 L 219 - G.H5 D 378 G.H5.10
Polar ICL2 H 127 34x50 G.H5 E 392 G.H5.24
Hydrophobic ICL2 H 127 34x50 G.H5 E 392 G.H5.24
Van-der-waals ICL2 H 127 34x50 G.H5 E 392 G.H5.24
Polar TM6 L 273 6x24 G.H5 R 385 G.H5.17
Hydrophobic TM6 L 273 6x24 G.H5 R 385 G.H5.17
Van-der-waals TM6 L 273 6x24 G.H5 R 385 G.H5.17
Polar TM5 R 211 5x72 G.H5 Q 384 G.H5.16
Polar ICL3 V 220 - G.H5 D 378 G.H5.10
Hydrophobic ICL3 V 272 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 V 272 - G.S6 Y 360 G.S6.02
Polar ICL3 R 269 - G.S6 H 362 G.S6.04
Aromatic ICL3 R 269 - G.S6 H 362 G.S6.04
Hydrophobic ICL3 R 269 - G.S6 H 362 G.S6.04
Van-der-waals ICL3 R 269 - G.S6 H 362 G.S6.04
Hydrophobic ICL3 L 219 - G.H5 I 382 G.H5.14
Polar TM3 A 125 3x55 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 125 3x55 G.H5 L 393 G.H5.25
Van-der-waals TM3 A 125 3x55 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 124 3x54 G.H5 E 392 G.H5.24
Van-der-waals TM3 I 124 3x54 G.H5 E 392 G.H5.24
Polar ICL3 P 216 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 P 216 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 P 216 - G.H5 D 381 G.H5.13
Polar TM5 M 214 5x75 G.H5 Q 384 G.H5.16
Hydrophobic TM5 M 214 5x75 G.H5 Q 384 G.H5.16
Van-der-waals TM5 M 214 5x75 G.H5 Q 384 G.H5.16