G14 - GPR31 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 217 6x30 G.H5 L 349 G.H5.20
Polar TM2 Y 49 2x39 G.H5 E 351 G.H5.22
Hydrophobic ICL2 S 127 - G.HN K 30 G.HN.52
Hydrophobic C-term P 314 - G.H3 P 258 G.H3.16
Polar ICL2 L 125 34x56 G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 L 125 34x56 G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 L 125 34x56 G.hns1 R 33 G.hns1.02
Hydrophobic TM3 V 116 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 204 5x65 G.H5 L 345 G.H5.16
Hydrophobic ICL2 R 120 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 R 120 34x51 G.H5 F 337 G.H5.08
Polar ICL2 L 126 34x57 G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 L 126 34x57 G.hns1 R 33 G.hns1.02
Ionic TM6 K 216 6x29 G.h4s6 E 317 G.h4s6.12
Polar TM6 K 216 6x29 G.h4s6 E 317 G.h4s6.12
Hydrophobic TM6 K 216 6x29 G.h4s6 E 317 G.h4s6.12
Van-der-waals TM6 K 216 6x29 G.h4s6 E 317 G.h4s6.12
Ionic TM5 R 207 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 207 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 207 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM6 L 223 6x36 G.H5 L 354 G.H5.25
Ionic ICL2 R 120 34x51 G.s2s3 E 193 G.s2s3.01
Polar ICL2 R 120 34x51 G.s2s3 E 193 G.s2s3.01
Hydrophobic ICL2 R 120 34x51 G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL2 R 120 34x51 G.s2s3 E 193 G.s2s3.01
Hydrophobic TM6 A 220 6x33 G.H5 V 355 G.H5.26
Hydrophobic TM7 S 285 7x56 G.H5 N 353 G.H5.24
Polar C-term Y 318 - G.H3 W 259 G.H3.17
Aromatic C-term Y 318 - G.H3 W 259 G.H3.17
Hydrophobic C-term Y 318 - G.H3 W 259 G.H3.17
Van-der-waals C-term Y 318 - G.H3 W 259 G.H3.17
Hydrophobic ICL2 R 120 34x51 G.H5 K 341 G.H5.12
Van-der-waals ICL2 R 120 34x51 G.H5 K 341 G.H5.12
Hydrophobic TM3 V 116 3x54 G.H5 F 352 G.H5.23
Polar TM3 R 112 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 F 352 G.H5.23
Polar H8 S 286 8x47 G.H5 N 353 G.H5.24
Hydrophobic H8 S 286 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 S 286 8x47 G.H5 N 353 G.H5.24
Hydrophobic TM5 L 204 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 204 5x65 G.H5 L 349 G.H5.20
Polar TM6 A 220 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 220 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 220 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM2 Y 49 2x39 G.H5 F 352 G.H5.23
Hydrophobic ICL2 R 120 34x51 G.S3 I 195 G.S3.01
Polar TM3 R 115 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 R 115 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 R 115 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 K 216 6x29 G.H5 V 355 G.H5.26
Van-der-waals TM6 K 216 6x29 G.H5 V 355 G.H5.26
Hydrophobic TM3 D 111 3x49 G.H5 F 352 G.H5.23
Van-der-waals TM3 D 111 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM3 V 116 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 V 116 3x54 G.H5 L 345 G.H5.16
Hydrophobic ICL2 L 125 34x56 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 L 125 34x56 G.hns1 R 34 G.hns1.03
Hydrophobic TM5 R 207 5x68 G.H5 L 345 G.H5.16
Van-der-waals TM5 R 207 5x68 G.H5 L 345 G.H5.16
Polar TM7 Y 282 7x53 G.H5 N 353 G.H5.24
Van-der-waals TM7 Y 282 7x53 G.H5 N 353 G.H5.24
Polar TM5 R 207 5x68 G.H5 K 341 G.H5.12
Van-der-waals TM5 R 207 5x68 G.H5 K 341 G.H5.12
Ionic TM2 K 47 2x37 G.H5 E 351 G.H5.22
Polar TM2 K 47 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM2 K 47 2x37 G.H5 E 351 G.H5.22
Van-der-waals TM2 K 47 2x37 G.H5 E 351 G.H5.22
Polar H8 P 287 8x48 G.H5 N 353 G.H5.24
Hydrophobic H8 P 287 8x48 G.H5 N 353 G.H5.24
Van-der-waals H8 P 287 8x48 G.H5 N 353 G.H5.24
Hydrophobic C-term R 315 - G.h3s5 L 261 G.h3s5.01
Van-der-waals C-term R 315 - G.h3s5 L 261 G.h3s5.01
Hydrophobic C-term R 315 - G.H3 P 258 G.H3.16
Hydrophobic TM6 A 220 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 119 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 K 122 34x53 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 K 122 34x53 G.hns1 R 34 G.hns1.03
Ionic TM3 R 115 3x53 G.H5 E 351 G.H5.22
Polar TM3 R 115 3x53 G.H5 E 351 G.H5.22
Hydrophobic C-term Y 318 - G.H3 P 258 G.H3.16
Hydrophobic TM6 V 224 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 224 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 115 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 115 3x53 G.H5 F 352 G.H5.23