GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | R | 120 | 34x51 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM2 | Y | 49 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | Y | 49 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | Y | 49 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Polar | TM5 | R | 207 | 5x68 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM3 | V | 116 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 116 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | L | 204 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Polar | TM6 | Q | 214 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | Q | 214 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 214 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL2 | R | 120 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | R | 120 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Ionic | TM6 | K | 213 | 6x26 | G.H4 | E | 309 | G.H4.16 |
Polar | TM6 | K | 213 | 6x26 | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM6 | K | 213 | 6x26 | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | TM6 | K | 213 | 6x26 | G.H4 | E | 309 | G.H4.16 |
Polar | TM6 | K | 216 | 6x29 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | TM6 | K | 216 | 6x29 | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | TM6 | K | 216 | 6x29 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | TM6 | L | 217 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | L | 217 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Ionic | TM5 | R | 207 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | R | 207 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | R | 207 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | R | 207 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | ICL2 | S | 127 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | S | 127 | - | G.HN | R | 24 | G.HN.48 |
Van-der-waals | ICL2 | S | 127 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | L | 223 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 223 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | H8 | P | 287 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | P | 287 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Polar | ICL2 | R | 120 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 120 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | TM6 | A | 220 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | A | 220 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL2 | K | 122 | 34x53 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 122 | 34x53 | G.hns1 | R | 32 | G.hns1.03 |
Ionic | ICL3 | R | 209 | - | G.H5 | D | 338 | G.H5.09 |
Polar | ICL3 | R | 209 | - | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | ICL3 | R | 209 | - | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | ICL2 | L | 125 | 34x56 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | L | 125 | 34x56 | G.hns1 | R | 31 | G.hns1.02 |
Polar | ICL2 | R | 120 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM3 | V | 116 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Polar | TM3 | R | 112 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Polar | ICL2 | Q | 129 | - | G.HN | R | 24 | G.HN.48 |
Van-der-waals | ICL2 | Q | 129 | - | G.HN | R | 24 | G.HN.48 |
Polar | H8 | S | 286 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | S | 286 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | S | 286 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM5 | L | 204 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | A | 220 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | Y | 49 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | R | 120 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | R | 120 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Polar | TM3 | R | 115 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | R | 115 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | R | 115 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | TM6 | K | 216 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 216 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 216 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Polar | C-term | Y | 318 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Hydrophobic | C-term | Y | 318 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Van-der-waals | C-term | Y | 318 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Hydrophobic | TM3 | V | 116 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 116 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM2 | P | 48 | 2x38 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | P | 48 | 2x38 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM5 | R | 207 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | R | 207 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Polar | TM5 | R | 207 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM5 | R | 207 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | TM5 | R | 207 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM2 | K | 47 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | K | 47 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | H8 | P | 287 | 8x48 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL2 | P | 119 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | L | 125 | 34x56 | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | ICL2 | L | 125 | 34x56 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 220 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | N | 124 | 34x55 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | P | 119 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 119 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM3 | R | 115 | 3x53 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM3 | R | 115 | 3x53 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM6 | V | 224 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | R | 115 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 115 | 3x53 | G.H5 | I | 352 | G.H5.23 |