Golf - GPR34 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 77.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 255 - G.S6 H 349 G.S6.04
Hydrophobic TM2 I 89 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 89 2x39 G.H5 L 380 G.H5.25
Polar ICL1 K 85 - G.hns1 K 40 G.hns1.02
Hydrophobic ICL1 K 85 - G.hns1 K 40 G.hns1.02
Van-der-waals ICL1 K 85 - G.hns1 K 40 G.hns1.02
Hydrophobic TM3 I 156 3x54 G.H5 L 381 G.H5.26
Van-der-waals TM3 I 156 3x54 G.H5 L 381 G.H5.26
Polar TM5 I 248 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM5 I 248 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 I 248 5x68 G.H5 R 372 G.H5.17
Hydrophobic ICL2 I 160 - G.H5 Q 371 G.H5.16
Van-der-waals ICL2 I 160 - G.H5 Q 371 G.H5.16
Polar TM6 K 260 6x30 G.h4s6 Y 345 G.h4s6.20
Aromatic TM6 K 260 6x30 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 K 260 6x30 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 K 260 6x30 G.h4s6 Y 345 G.h4s6.20
Polar ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 252 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic TM3 K 155 3x53 G.H5 L 380 G.H5.25
Van-der-waals TM3 K 155 3x53 G.H5 L 380 G.H5.25
Polar TM4 K 169 4x40 G.HN K 30 G.HN.45
Polar H8 N 333 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 N 333 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 N 333 8x49 G.H5 E 379 G.H5.24
Hydrophobic ICL3 F 255 - G.S6 Y 347 G.S6.02
Van-der-waals ICL3 F 255 - G.S6 Y 347 G.S6.02
Hydrophobic TM3 K 155 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 K 155 3x53 G.H5 L 375 G.H5.20
Polar ICL3 P 256 - G.h4s6 Y 345 G.h4s6.20
Polar TM6 K 260 6x30 G.h4s6 K 343 G.h4s6.12
Hydrophobic TM6 K 260 6x30 G.h4s6 K 343 G.h4s6.12
Van-der-waals TM6 K 260 6x30 G.h4s6 K 343 G.h4s6.12
Polar ICL2 T 168 - G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 T 168 - G.hns1 K 40 G.hns1.02
Polar ICL2 R 163 - G.S3 N 205 G.S3.02
Hydrophobic ICL2 R 163 - G.S3 N 205 G.S3.02
Van-der-waals ICL2 R 163 - G.S3 N 205 G.S3.02
Polar ICL2 Q 161 - G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 Q 161 - G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 Q 161 - G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 I 160 - G.S1 H 43 G.S1.02
Van-der-waals ICL2 I 160 - G.S1 H 43 G.S1.02
Polar ICL1 K 85 - G.hns1 Y 39 G.hns1.01
Aromatic ICL1 K 85 - G.hns1 Y 39 G.hns1.01
Hydrophobic ICL1 K 85 - G.hns1 Y 39 G.hns1.01
Van-der-waals ICL1 K 85 - G.hns1 Y 39 G.hns1.01
Van-der-waals ICL3 R 252 - G.H5 R 372 G.H5.17
Hydrophobic TM4 K 169 4x40 G.HN K 34 G.HN.49
Polar ICL2 R 163 - G.S2 Q 200 G.S2.07
Hydrophobic ICL2 R 163 - G.S2 Q 200 G.S2.07
Van-der-waals ICL2 R 163 - G.S2 Q 200 G.S2.07
Polar TM3 R 152 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 152 3x50 G.H5 L 380 G.H5.25
Polar TM2 Q 90 2x40 G.H5 E 379 G.H5.24
Hydrophobic TM2 Q 90 2x40 G.H5 E 379 G.H5.24
Van-der-waals TM2 Q 90 2x40 G.H5 E 379 G.H5.24
Polar H8 S 332 8x48 G.H5 E 379 G.H5.24
Hydrophobic ICL1 K 85 - G.HN R 36 G.HN.51
Hydrophobic ICL3 N 257 - G.h4s6 Y 345 G.h4s6.20
Van-der-waals ICL3 N 257 - G.h4s6 Y 345 G.h4s6.20
Polar TM6 Y 261 6x31 G.H5 R 372 G.H5.17
Aromatic TM6 Y 261 6x31 G.H5 R 372 G.H5.17
Hydrophobic TM6 Y 261 6x31 G.H5 R 372 G.H5.17
Van-der-waals TM6 Y 261 6x31 G.H5 R 372 G.H5.17
Polar TM2 N 87 2x37 G.H5 Y 378 G.H5.23
Hydrophobic TM2 N 87 2x37 G.H5 Y 378 G.H5.23
Van-der-waals TM2 N 87 2x37 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 T 168 - G.HN L 37 G.HN.52
Van-der-waals ICL2 T 168 - G.HN L 37 G.HN.52
Polar ICL1 R 86 - G.hns1 K 40 G.hns1.02
Van-der-waals ICL1 R 86 - G.hns1 K 40 G.hns1.02
Hydrophobic TM4 K 169 4x40 G.HN L 37 G.HN.52
Polar ICL3 N 257 - G.S6 Y 347 G.S6.02
Hydrophobic ICL3 N 257 - G.S6 Y 347 G.S6.02
Van-der-waals ICL3 N 257 - G.S6 Y 347 G.S6.02
Hydrophobic TM5 L 245 5x65 G.H5 L 381 G.H5.26
Polar H8 S 331 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 S 331 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 S 331 8x47 G.H5 E 379 G.H5.24
Polar ICL2 Q 161 - G.s2s3 K 203 G.s2s3.02
Hydrophobic ICL2 Q 161 - G.s2s3 K 203 G.s2s3.02
Van-der-waals ICL2 Q 161 - G.s2s3 K 203 G.s2s3.02
Polar TM2 N 87 2x37 G.H5 E 379 G.H5.24
Van-der-waals TM2 N 87 2x37 G.H5 E 379 G.H5.24
Hydrophobic ICL3 R 252 - G.H5 I 369 G.H5.14
Van-der-waals ICL3 R 252 - G.H5 I 369 G.H5.14
Ionic ICL1 R 84 - G.h2s4 D 227 G.h2s4.03
Hydrophobic ICL3 F 255 - G.S6 P 348 G.S6.03
Hydrophobic TM6 K 260 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM6 T 264 6x34 G.H5 L 381 G.H5.26
Van-der-waals TM6 T 264 6x34 G.H5 L 381 G.H5.26
Polar TM6 Y 261 6x31 G.S6 Y 347 G.S6.02
Van-der-waals TM6 Y 261 6x31 G.S6 Y 347 G.S6.02
Hydrophobic TM3 I 156 3x54 G.H5 L 375 G.H5.20
Polar TM4 K 169 4x40 G.HN Q 33 G.HN.48
Hydrophobic TM4 K 169 4x40 G.HN Q 33 G.HN.48
Van-der-waals TM4 K 169 4x40 G.HN Q 33 G.HN.48
Polar ICL3 K 254 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 K 254 - G.hgh4 D 310 G.hgh4.13
Polar H8 K 336 8x52 G.h3s5 T 271 G.h3s5.02
Hydrophobic H8 K 336 8x52 G.h3s5 T 271 G.h3s5.02
Van-der-waals H8 K 336 8x52 G.h3s5 T 271 G.h3s5.02
Hydrophobic ICL2 T 167 - G.HN L 37 G.HN.52
Van-der-waals ICL2 T 167 - G.HN L 37 G.HN.52
Hydrophobic ICL2 I 160 - G.s2s3 K 203 G.s2s3.02
Polar TM6 K 260 6x30 G.h4s6 H 344 G.h4s6.13
Van-der-waals TM6 K 260 6x30 G.h4s6 H 344 G.h4s6.13
Ionic ICL3 R 252 - G.H5 D 365 G.H5.10
Polar ICL3 R 252 - G.H5 D 365 G.H5.10
Hydrophobic ICL3 R 252 - G.H5 D 365 G.H5.10
Van-der-waals ICL3 R 252 - G.H5 D 365 G.H5.10
Polar ICL2 I 160 - G.S3 V 204 G.S3.01
Hydrophobic ICL2 I 160 - G.S3 V 204 G.S3.01
Van-der-waals ICL2 I 160 - G.S3 V 204 G.S3.01
Hydrophobic TM2 I 89 2x39 G.H5 E 379 G.H5.24
Ionic ICL1 K 85 - G.h2s4 D 227 G.h2s4.03
Polar ICL1 K 85 - G.h2s4 D 227 G.h2s4.03
Van-der-waals ICL3 K 254 - G.hgh4 T 312 G.hgh4.15
Polar TM3 R 152 3x50 G.H5 E 379 G.H5.24
Hydrophobic TM3 S 159 3x57 G.H5 Q 371 G.H5.16
Polar ICL3 N 257 - G.S6 C 346 G.S6.01
Van-der-waals ICL3 N 257 - G.S6 C 346 G.S6.01
Polar TM6 K 260 6x30 G.h4s6 G 342 G.h4s6.11
Hydrophobic TM6 K 260 6x30 G.h4s6 G 342 G.h4s6.11
Van-der-waals TM6 K 260 6x30 G.h4s6 G 342 G.h4s6.11