G12 - GPR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 234 6x22 G.H4 V 332 G.H4.12
Polar TM6 A 241 6x29 G.H5 Q 381 G.H5.26
Polar ICL2 Y 145 34x54 G.H5 N 374 G.H5.19
Hydrophobic TM6 L 234 6x22 G.H4 D 336 G.H4.16
Van-der-waals TM6 L 234 6x22 G.H4 D 336 G.H4.16
Hydrophobic TM3 L 138 3x54 G.H5 L 375 G.H5.20
Ionic C-term R 325 - G.H5 D 377 G.H5.22
Polar C-term R 325 - G.H5 D 377 G.H5.22
Van-der-waals C-term R 325 - G.H5 D 377 G.H5.22
Hydrophobic TM6 L 249 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 249 6x37 G.H5 I 378 G.H5.23
Polar TM4 T 148 4x37 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 Q 230 5x75 G.S6 F 347 G.S6.02
Van-der-waals TM5 Q 230 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM5 I 219 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM7 I 296 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 296 7x52 G.H5 L 380 G.H5.25
Hydrophobic C-term S 328 - G.hns1 V 54 G.hns1.01
Van-der-waals C-term S 328 - G.hns1 V 54 G.hns1.01
Hydrophobic ICL2 L 142 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 142 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 A 141 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 A 141 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 141 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 Y 145 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Y 145 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 E 147 4x36 G.hns1 R 56 G.hns1.03
Polar C-term P 327 - G.h2s4 G 244 G.h2s4.03
Hydrophobic C-term P 327 - G.h2s4 G 244 G.h2s4.03
Van-der-waals C-term P 327 - G.h2s4 G 244 G.h2s4.03
Polar TM6 H 238 6x26 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 H 238 6x26 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 H 238 6x26 G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term V 330 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term V 330 - G.h2s4 D 243 G.h2s4.02
Hydrophobic TM6 T 248 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 248 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 138 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 138 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 234 6x22 G.S6 L 346 G.S6.01
Hydrophobic TM2 M 75 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM5 V 220 5x65 G.H5 M 379 G.H5.24
Hydrophobic C-term S 328 - G.HN R 51 G.HN.51
Ionic C-term D 329 - G.hns1 R 55 G.hns1.02
Polar C-term S 326 - G.hns1 R 55 G.hns1.02
Hydrophobic C-term S 326 - G.hns1 R 55 G.hns1.02
Van-der-waals C-term S 326 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 L 233 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 A 141 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM3 L 138 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 138 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 231 5x76 G.S6 H 348 G.S6.03
Hydrophobic TM5 I 227 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 R 231 5x76 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 R 231 5x76 G.h4s6 P 345 G.h4s6.20
Polar TM3 S 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 137 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 137 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 142 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 L 234 6x22 G.S6 H 348 G.S6.03
Hydrophobic TM4 S 146 4x35 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 S 146 4x35 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 L 233 - G.H4 R 329 G.H4.09
Polar TM5 Q 230 5x75 G.S6 H 348 G.S6.03
Hydrophobic TM5 Q 230 5x75 G.S6 H 348 G.S6.03
Van-der-waals TM5 Q 230 5x75 G.S6 H 348 G.S6.03
Polar TM6 H 238 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 H 238 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 H 238 6x26 G.h4s6 P 345 G.h4s6.20
Polar TM5 R 231 5x76 G.S6 L 346 G.S6.01
Hydrophobic TM5 R 231 5x76 G.S6 L 346 G.S6.01
Van-der-waals TM5 R 231 5x76 G.S6 L 346 G.S6.01
Polar C-term R 323 - G.H3 K 284 G.H3.16
Hydrophobic TM6 T 248 6x36 G.H5 L 380 G.H5.25
Polar TM7 R 300 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 R 300 7x56 G.H5 L 380 G.H5.25
Ionic C-term D 329 - G.HN R 51 G.HN.51
Polar C-term D 329 - G.HN R 51 G.HN.51
Hydrophobic C-term D 329 - G.HN R 51 G.HN.51
Van-der-waals C-term D 329 - G.HN R 51 G.HN.51
Hydrophobic ICL3 L 233 - G.H4 V 332 G.H4.12
Polar TM3 R 134 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 138 3x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 T 143 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 T 143 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM5 H 223 5x68 G.H5 L 371 G.H5.16
Hydrophobic C-term S 328 - G.h2s4 G 244 G.h2s4.03
Hydrophobic ICL3 L 233 - G.H4 Q 328 G.H4.08
Hydrophobic TM6 H 238 6x26 G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 Y 145 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 G 245 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 245 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 Q 230 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM5 I 227 5x72 G.S6 F 347 G.S6.02
Polar TM6 H 238 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 238 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 238 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 L 249 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 142 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 142 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 142 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 V 220 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 220 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 142 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 142 34x51 G.H5 F 363 G.H5.08
Ionic TM5 H 223 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 V 252 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 227 5x72 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 L 233 - G.S6 F 350 G.S6.05
Hydrophobic ICL2 L 142 34x51 G.S1 V 58 G.S1.02
Ionic TM4 E 147 4x36 G.HN R 52 G.HN.52
Polar TM4 E 147 4x36 G.HN R 52 G.HN.52
Hydrophobic TM4 E 147 4x36 G.HN R 52 G.HN.52
Van-der-waals TM4 E 147 4x36 G.HN R 52 G.HN.52