GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | Q | 250 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | Q | 250 | - | G.H5 | F | 339 | G.H5.06 |
Polar | C-term | R | 355 | - | G.h3s5 | S | 267 | G.h3s5.03 |
Van-der-waals | C-term | R | 355 | - | G.h3s5 | S | 267 | G.h3s5.03 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM6 | A | 265 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | A | 265 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | F | 331 | 8x50 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | P | 359 | - | G.S3 | R | 202 | G.S3.04 |
Hydrophobic | C-term | P | 359 | - | G.S3 | R | 202 | G.S3.04 |
Van-der-waals | C-term | P | 359 | - | G.S3 | R | 202 | G.S3.04 |
Hydrophobic | TM6 | K | 262 | 6x30 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | C-term | Y | 363 | - | G.S2 | E | 191 | G.S2.03 |
Polar | C-term | Y | 363 | - | G.H2 | H | 218 | G.H2.09 |
Polar | TM2 | N | 70 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | N | 70 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | N | 70 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | I | 328 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Polar | TM2 | S | 67 | 2x37 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | S | 67 | 2x37 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | N | 70 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | N | 70 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Polar | TM3 | R | 132 | 3x50 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM3 | R | 132 | 3x50 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | R | 352 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | C-term | R | 352 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Polar | C-term | C | 365 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | C-term | C | 365 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | C | 365 | - | G.S2 | I | 189 | G.S2.01 |
Polar | ICL3 | Q | 250 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | ICL3 | Q | 250 | - | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | ICL3 | Q | 250 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | ICL3 | L | 238 | - | G.H4 | R | 306 | G.H4.08 |
Hydrophobic | TM6 | T | 268 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM2 | L | 73 | 2x43 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | L | 73 | 2x43 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | F | 261 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | F | 261 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | H8 | I | 328 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | I | 328 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | A | 371 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | A | 371 | - | H.hbhc | E | 119 | H.hbhc.01 |
Polar | ICL1 | P | 63 | 12x48 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | P | 63 | 12x48 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | P | 63 | 12x48 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM2 | I | 69 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | I | 69 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL2 | D | 141 | - | G.H5 | L | 353 | G.H5.20 |
Polar | ICL3 | Q | 254 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | ICL3 | Q | 254 | - | G.H5 | A | 343 | G.H5.10 |
Van-der-waals | ICL3 | Q | 254 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | TM1 | V | 59 | 1x57 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | Q | 369 | - | G.hfs2 | T | 187 | G.hfs2.06 |
Hydrophobic | C-term | Q | 369 | - | G.hfs2 | T | 187 | G.hfs2.06 |
Van-der-waals | C-term | Q | 369 | - | G.hfs2 | T | 187 | G.hfs2.06 |
Aromatic | H8 | K | 330 | 8x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL3 | Q | 253 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM2 | I | 69 | 2x39 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM2 | I | 69 | 2x39 | G.H5 | V | 359 | G.H5.26 |
Polar | TM6 | V | 257 | 6x25 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | C-term | I | 357 | - | G.h2s4 | N | 222 | G.h2s4.03 |
Van-der-waals | C-term | I | 357 | - | G.h2s4 | N | 222 | G.h2s4.03 |
Hydrophobic | ICL1 | A | 64 | 12x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL1 | A | 64 | 12x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | L | 73 | 2x43 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM2 | L | 73 | 2x43 | G.H5 | V | 359 | G.H5.26 |
Ionic | TM6 | D | 258 | 6x26 | G.H5 | K | 354 | G.H5.21 |
Polar | TM6 | D | 258 | 6x26 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | D | 258 | 6x26 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM6 | I | 269 | 6x37 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | I | 269 | 6x37 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL1 | R | 66 | 12x51 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | R | 66 | 12x51 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | R | 66 | 12x51 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | ICL1 | M | 65 | 12x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | R | 355 | - | G.h2s4 | V | 223 | G.h2s4.04 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | V | 223 | G.h2s4.04 |
Van-der-waals | C-term | R | 355 | - | G.h2s4 | V | 223 | G.h2s4.04 |
Polar | C-term | R | 356 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | C-term | R | 356 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Ionic | H8 | K | 330 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Polar | H8 | K | 330 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | H8 | K | 330 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | K | 330 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM6 | S | 260 | 6x28 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | TM2 | N | 70 | 2x40 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | N | 70 | 2x40 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | N | 70 | 2x40 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | R | 355 | - | G.h2s4 | N | 222 | G.h2s4.03 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | N | 222 | G.h2s4.03 |
Van-der-waals | C-term | R | 355 | - | G.h2s4 | N | 222 | G.h2s4.03 |
Polar | TM6 | D | 258 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | D | 258 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | D | 258 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM7 | Y | 324 | 7x53 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | R | 355 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | R | 355 | - | G.H3 | W | 263 | G.H3.17 |
Polar | ICL1 | A | 64 | 12x49 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | A | 64 | 12x49 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | A | 64 | 12x49 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | M | 65 | 12x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | I | 353 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | I | 353 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | C-term | V | 372 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | C-term | V | 372 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | V | 372 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | C-term | C | 365 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | C | 365 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | TM1 | V | 55 | 1x53 | G.H5 | L | 358 | G.H5.25 |
Polar | TM2 | S | 67 | 2x37 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL1 | P | 63 | 12x48 | G.HN | K | 33 | G.HN.51 |