G12 - GPR61 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 148 34x51 G.H5 K 367 G.H5.12
Hydrophobic C-term F 384 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 384 - G.H3 T 279 G.H3.11
Hydrophobic TM6 K 284 6x32 G.H5 L 380 G.H5.25
Hydrophobic C-term I 418 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term I 418 - G.s4h3 M 262 G.s4h3.09
Hydrophobic ICL2 M 148 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 M 148 34x51 G.H5 F 363 G.H5.08
Polar H8 R 346 8x48 G.H5 D 377 G.H5.22
Hydrophobic H8 R 346 8x48 G.H5 D 377 G.H5.22
Van-der-waals H8 R 346 8x48 G.H5 D 377 G.H5.22
Hydrophobic TM6 V 288 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 288 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 149 34x52 G.S3 I 221 G.S3.01
Polar C-term I 435 - G.S2 I 211 G.S2.01
Polar C-term Q 417 - G.s4h3 M 262 G.s4h3.09
Hydrophobic C-term Q 417 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term Q 417 - G.s4h3 M 262 G.s4h3.09
Hydrophobic ICL2 M 148 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 148 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 V 144 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 140 3x50 G.H5 I 378 G.H5.23
Polar ICL2 V 152 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 152 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 152 34x55 G.S3 I 221 G.S3.01
Polar C-term R 413 - H.HA K 114 H.HA.28
Van-der-waals C-term R 413 - H.HA K 114 H.HA.28
Hydrophobic ICL2 P 147 34x50 G.H5 K 367 G.H5.12
Polar TM3 Y 143 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 Y 143 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 Y 143 3x53 G.H5 N 374 G.H5.19
Hydrophobic C-term L 385 - G.H2 W 238 G.H2.07
Polar C-term E 420 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term E 420 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals C-term E 420 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic TM5 V 234 5x64 G.H5 L 371 G.H5.16
Hydrophobic C-term F 384 - G.H3 I 276 G.H3.08
Polar C-term E 421 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term E 421 - G.hfs2 K 209 G.hfs2.06
Hydrophobic ICL2 P 147 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 370 G.H5.15
Hydrophobic C-term E 420 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM4 L 156 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 L 156 4x39 G.HN R 52 G.HN.52
Polar C-term Y 440 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term Y 440 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term Y 440 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term P 415 - H.HA K 114 H.HA.28
Van-der-waals C-term P 415 - H.HA K 114 H.HA.28
Polar C-term Q 386 - G.H2 Q 236 G.H2.05
Hydrophobic C-term Q 386 - G.H2 Q 236 G.H2.05
Van-der-waals C-term Q 386 - G.H2 Q 236 G.H2.05
Hydrophobic C-term F 381 - G.H3 N 283 G.H3.15
Van-der-waals C-term F 381 - G.H3 N 283 G.H3.15
Hydrophobic H8 R 349 8x51 G.H5 M 379 G.H5.24
Van-der-waals H8 R 349 8x51 G.H5 M 379 G.H5.24
Hydrophobic ICL2 V 152 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 V 152 34x55 G.S3 P 222 G.S3.02
Polar C-term I 414 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term I 414 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term I 414 - G.s4h3 R 265 G.s4h3.12
Ionic TM2 K 75 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL3 M 249 - G.H4 Q 328 G.H4.08
Van-der-waals ICL3 M 249 - G.H4 Q 328 G.H4.08
Hydrophobic ICL3 M 249 - G.S6 F 350 G.S6.05
Van-der-waals ICL3 M 249 - G.S6 F 350 G.S6.05
Hydrophobic ICL2 M 148 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 148 34x51 G.H5 I 370 G.H5.15
Polar ICL2 E 151 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 151 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 151 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic C-term T 388 - G.H3 N 275 G.H3.07
Polar C-term Y 440 - G.h1ha D 86 G.h1ha.05
Hydrophobic TM3 Y 143 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 Y 143 3x53 G.H5 I 378 G.H5.23
Hydrophobic C-term I 377 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 M 148 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 V 144 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM7 L 344 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 L 344 7x56 G.H5 M 379 G.H5.24
Aromatic C-term F 381 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term F 381 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term F 381 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term F 381 - G.H3 I 280 G.H3.12
Van-der-waals C-term F 381 - G.H3 I 280 G.H3.12
Polar H8 Q 347 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 Q 347 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 Q 347 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM5 A 238 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL3 M 249 - G.HG M 298 G.HG.01
Polar TM3 Y 143 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM3 Y 143 3x53 G.H5 D 377 G.H5.22
Van-der-waals TM3 Y 143 3x53 G.H5 D 377 G.H5.22
Hydrophobic C-term G 389 - G.H2 R 232 G.H2.01
Hydrophobic ICL2 E 151 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 151 34x54 G.hns1 R 55 G.hns1.02
Polar C-term D 433 - G.S2 I 211 G.S2.01
Van-der-waals C-term D 433 - G.S2 I 211 G.S2.01
Polar ICL2 M 154 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 M 154 34x57 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 M 154 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 M 231 5x61 G.H5 L 380 G.H5.25
Hydrophobic C-term P 415 - H.HA A 111 H.HA.25
Polar TM6 A 285 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 285 6x33 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 147 34x50 G.H5 L 371 G.H5.16
Hydrophobic C-term F 384 - G.H3 N 275 G.H3.07
Van-der-waals C-term F 384 - G.H3 N 275 G.H3.07
Hydrophobic TM3 V 144 3x54 G.H5 I 378 G.H5.23
Polar C-term Q 417 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term Q 417 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term Q 417 - G.s4h3 R 265 G.s4h3.12
Polar ICL1 A 72 12x49 G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 A 72 12x49 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 A 72 12x49 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 245 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM5 L 245 5x75 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 245 5x75 G.S6 F 347 G.S6.02
Hydrophobic C-term L 382 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 382 - G.H2 Q 236 G.H2.05
Van-der-waals H8 N 345 8x47 G.H5 D 377 G.H5.22
Hydrophobic C-term I 377 - G.H3 N 283 G.H3.15
Van-der-waals C-term I 377 - G.H3 N 283 G.H3.15
Hydrophobic C-term L 426 - G.H2 K 237 G.H2.06
Hydrophobic C-term L 382 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 M 148 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL2 M 148 34x51 G.H5 V 366 G.H5.11
Hydrophobic C-term L 441 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term L 441 - G.h1ha R 83 G.h1ha.02
Polar C-term Y 440 - G.H1 R 78 G.H1.09
Aromatic C-term Y 440 - G.H1 R 78 G.H1.09
Hydrophobic C-term Y 440 - G.H1 R 78 G.H1.09
Van-der-waals C-term Y 440 - G.H1 R 78 G.H1.09
Ionic C-term E 374 - G.H3 K 284 G.H3.16
Polar C-term L 385 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 385 - G.H2 R 235 G.H2.04
Hydrophobic TM5 A 238 5x68 G.H5 L 375 G.H5.20
Hydrophobic C-term I 418 - H.HA K 103 H.HA.17
Hydrophobic C-term F 381 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 381 - G.H3 T 279 G.H3.11
Polar C-term G 416 - H.HA D 110 H.HA.24
Van-der-waals ICL2 P 147 34x50 G.H5 N 374 G.H5.19
Hydrophobic C-term L 385 - G.H3 I 276 G.H3.08
Hydrophobic C-term G 416 - H.HA V 107 H.HA.21
Van-der-waals C-term G 416 - H.HA V 107 H.HA.21
Polar TM5 H 242 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 242 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 242 5x72 G.H5 Q 372 G.H5.17
Polar C-term T 388 - G.H3 E 272 G.H3.04
Hydrophobic C-term F 381 - G.H3 F 286 G.H3.18
Polar C-term P 415 - H.HA D 110 H.HA.24
Hydrophobic C-term P 415 - H.HA D 110 H.HA.24
Van-der-waals C-term P 415 - H.HA D 110 H.HA.24
Hydrophobic TM6 V 288 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM5 A 235 5x65 G.H5 L 375 G.H5.20
Polar C-term R 442 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term R 442 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term R 442 - G.h1ha R 83 G.h1ha.02
Hydrophobic TM4 T 155 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 155 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 T 247 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 T 247 - G.S6 H 348 G.S6.03
Polar TM6 K 284 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 284 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 284 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 M 148 34x51 G.S3 F 223 G.S3.03
Van-der-waals ICL2 M 148 34x51 G.S3 F 223 G.S3.03
Hydrophobic ICL3 R 253 - G.H4 R 323 G.H4.03
Van-der-waals ICL3 R 253 - G.H4 R 323 G.H4.03
Polar C-term S 437 - G.S2 E 213 G.S2.03
Hydrophobic C-term I 377 - G.H3 L 285 G.H3.17
Van-der-waals C-term G 416 - H.hdhe Q 174 H.hdhe.02
Hydrophobic TM3 V 144 3x54 G.H5 L 380 G.H5.25
Ionic C-term D 433 - G.H2 K 237 G.H2.06
Polar C-term D 433 - G.H2 K 237 G.H2.06
Van-der-waals C-term D 433 - G.H2 K 237 G.H2.06