GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Polar | H8 | R | 346 | 8x48 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | H8 | R | 346 | 8x48 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | H8 | R | 346 | 8x48 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | C-term | I | 414 | - | G.s4h3 | V | 243 | G.s4h3.07 |
Hydrophobic | TM6 | V | 288 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | V | 288 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM5 | A | 239 | 5x69 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM5 | L | 245 | 5x75 | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | TM2 | F | 76 | 2x40 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | F | 76 | 2x40 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Aromatic | TM3 | Y | 143 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | Y | 143 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | Y | 143 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Aromatic | C-term | F | 381 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | C-term | F | 381 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Van-der-waals | C-term | F | 381 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | TM5 | V | 234 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | V | 234 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL2 | M | 148 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM6 | G | 281 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | TM5 | H | 242 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Aromatic | TM5 | H | 242 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM5 | L | 245 | 5x75 | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | TM5 | L | 245 | 5x75 | G.h4s6 | T | 337 | G.h4s6.03 |
Aromatic | ICL3 | W | 248 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | ICL3 | W | 248 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Van-der-waals | ICL3 | W | 248 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | TM4 | L | 156 | 4x39 | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | TM4 | L | 156 | 4x39 | G.HN | Q | 33 | G.HN.48 |
Ionic | H8 | R | 349 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 349 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | R | 349 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | R | 349 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | G | 281 | 6x29 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | P | 246 | 5x76 | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | C-term | F | 381 | - | G.H2 | R | 218 | G.H2.04 |
Van-der-waals | C-term | F | 381 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | C-term | I | 377 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | I | 377 | - | G.H2 | I | 222 | G.H2.08 |
Polar | TM5 | Q | 241 | 5x71 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | P | 415 | - | H.HA | T | 99 | H.HA.28 |
Van-der-waals | C-term | P | 415 | - | H.HA | T | 99 | H.HA.28 |
Hydrophobic | ICL3 | W | 248 | - | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | ICL3 | W | 248 | - | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | TM3 | Y | 143 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | Y | 143 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | L | 382 | - | G.H2 | R | 219 | G.H2.05 |
Van-der-waals | C-term | L | 382 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | ICL2 | V | 152 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Ionic | C-term | E | 420 | - | G.hfs2 | R | 188 | G.hfs2.02 |
Polar | C-term | E | 420 | - | G.hfs2 | R | 188 | G.hfs2.02 |
Hydrophobic | C-term | E | 420 | - | G.hfs2 | R | 188 | G.hfs2.02 |
Van-der-waals | C-term | E | 420 | - | G.hfs2 | R | 188 | G.hfs2.02 |
Polar | TM3 | V | 144 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM7 | L | 344 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | L | 344 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | P | 246 | 5x76 | G.H4 | D | 330 | G.H4.13 |
Polar | H8 | Q | 347 | 8x49 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | H8 | Q | 347 | 8x49 | G.H5 | Q | 377 | G.H5.22 |
Aromatic | TM5 | H | 242 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | C-term | T | 388 | - | G.H3 | D | 258 | G.H3.07 |
Hydrophobic | ICL3 | W | 248 | - | G.H4 | L | 331 | G.H4.14 |
Ionic | ICL2 | R | 149 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Polar | ICL2 | R | 149 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 149 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Hydrophobic | C-term | I | 418 | - | H.HA | V | 91 | H.HA.20 |
Hydrophobic | C-term | E | 420 | - | G.hfs2 | L | 190 | G.hfs2.04 |
Hydrophobic | C-term | I | 418 | - | H.HA | T | 92 | H.HA.21 |
Van-der-waals | C-term | I | 418 | - | H.HA | T | 92 | H.HA.21 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | M | 231 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Polar | TM6 | A | 285 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | A | 285 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 285 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | I | 414 | - | H.hdhe | Y | 156 | H.hdhe.01 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL3 | M | 249 | - | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | ICL3 | M | 249 | - | G.H4 | R | 334 | G.H4.17 |
Polar | C-term | Q | 417 | - | G.s4h3 | R | 245 | G.s4h3.09 |
Polar | H8 | N | 345 | 8x47 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | H8 | N | 345 | 8x47 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | H8 | N | 345 | 8x47 | G.H5 | Q | 377 | G.H5.22 |
Polar | C-term | F | 384 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | C-term | F | 384 | - | G.H3 | S | 262 | G.H3.11 |
Van-der-waals | C-term | F | 384 | - | G.H3 | S | 262 | G.H3.11 |
Ionic | TM6 | K | 284 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Polar | TM6 | K | 284 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 284 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Ionic | C-term | E | 420 | - | G.s4h3 | R | 245 | G.s4h3.09 |
Hydrophobic | C-term | E | 420 | - | G.s4h3 | R | 245 | G.s4h3.09 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | TM5 | P | 246 | 5x76 | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | C-term | I | 414 | - | H.HD | E | 155 | H.HD.12 |
Hydrophobic | ICL2 | R | 149 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Polar | TM5 | A | 238 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | A | 238 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | A | 238 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | E | 378 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | C-term | L | 385 | - | G.H2 | R | 218 | G.H2.04 |
Van-der-waals | C-term | L | 385 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | C-term | F | 381 | - | G.H2 | W | 221 | G.H2.07 |
Hydrophobic | TM5 | A | 235 | 5x65 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | C-term | F | 381 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | C-term | F | 384 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | ICL3 | W | 248 | - | G.H4 | F | 327 | G.H4.10 |
Hydrophobic | C-term | I | 377 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | I | 377 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | TM5 | A | 238 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Polar | H8 | R | 346 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | H8 | R | 346 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | H8 | R | 346 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | V | 234 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | L | 385 | - | G.H3 | L | 259 | G.H3.08 |
Polar | TM5 | H | 242 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Aromatic | TM5 | H | 242 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | V | 288 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | A | 235 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | TM6 | K | 284 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 284 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Polar | ICL3 | W | 248 | - | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | ICL3 | W | 248 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | ICL3 | W | 248 | - | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | ICL2 | E | 151 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | E | 151 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | E | 421 | - | H.hbhc | T | 125 | H.hbhc.02 |
Van-der-waals | C-term | E | 421 | - | H.hbhc | T | 125 | H.hbhc.02 |
Hydrophobic | C-term | F | 381 | - | G.H2 | I | 222 | G.H2.08 |
Polar | C-term | Q | 417 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Hydrophobic | C-term | Q | 417 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Van-der-waals | C-term | Q | 417 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Polar | C-term | E | 420 | - | G.s3h2 | Q | 214 | G.s3h2.03 |
Van-der-waals | C-term | E | 420 | - | G.s3h2 | Q | 214 | G.s3h2.03 |
Ionic | H8 | R | 346 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 346 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | R | 346 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | R | 346 | 8x48 | G.H5 | E | 379 | G.H5.24 |