Gt2 - GPR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 76.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 175 34x52 G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 T 175 34x52 G.hns1 E 30 G.hns1.01
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23
Polar TM5 I 259 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 259 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 259 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 281 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 174 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 174 34x51 G.S1 V 34 G.S1.02
Ionic TM5 H 255 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 255 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 255 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 255 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 L 170 3x54 G.H5 N 347 G.H5.19
Polar ICL3 Q 262 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 Q 262 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 Q 262 - G.H5 D 337 G.H5.09
Hydrophobic TM6 A 273 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 273 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 L 170 3x54 G.H5 C 351 G.H5.23
Hydrophobic C-term F 354 - G.H3 K 257 G.H3.16
Hydrophobic C-term P 359 - G.H3 H 256 G.H3.15
Hydrophobic TM2 M 107 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 107 2x39 G.H5 D 350 G.H5.22
Polar ICL2 R 180 34x57 G.HN L 23 G.HN.47
Hydrophobic ICL2 R 180 34x57 G.HN L 23 G.HN.47
Van-der-waals ICL2 R 180 34x57 G.HN L 23 G.HN.47
Hydrophobic C-term F 354 - G.h4s6 R 313 G.h4s6.04
Van-der-waals C-term F 354 - G.h4s6 R 313 G.h4s6.04
Hydrophobic ICL3 Q 262 - G.H5 F 334 G.H5.06
Hydrophobic TM3 Y 171 3x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 174 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 H 270 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 266 6x22 G.S6 H 322 G.S6.04
Polar ICL2 L 174 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 L 174 34x51 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 L 174 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM3 N 172 3x56 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 N 172 3x56 G.hns1 K 32 G.hns1.03
Polar ICL3 Q 262 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 Q 262 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 Q 262 - G.H5 A 338 G.H5.10
Hydrophobic TM6 T 274 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 280 6x36 G.H5 G 352 G.H5.24
Hydrophobic H8 R 338 8x52 G.h4s6 V 316 G.h4s6.10
Hydrophobic TM5 H 255 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 255 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 N 172 3x56 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 N 172 3x56 G.hns1 A 31 G.hns1.02
Ionic TM5 R 254 5x67 G.s2s3 D 193 G.s2s3.02
Polar ICL3 Q 262 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 Q 262 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 C 265 - G.H5 F 334 G.H5.06
Hydrophobic TM6 L 266 6x22 G.H5 F 334 G.H5.06
Hydrophobic ICL2 T 175 34x52 G.S1 T 33 G.S1.01
Van-der-waals ICL2 T 175 34x52 G.S1 T 33 G.S1.01
Polar TM5 Q 258 5x71 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 Q 258 5x71 G.s2s3 K 192 G.s2s3.01
Van-der-waals TM5 Q 258 5x71 G.s2s3 K 192 G.s2s3.01
Hydrophobic C-term V 362 - G.H3 H 248 G.H3.07
Van-der-waals C-term V 362 - G.H3 H 248 G.H3.07
Hydrophobic ICL2 L 174 34x51 G.S1 T 33 G.S1.01
Van-der-waals ICL2 L 174 34x51 G.S1 T 33 G.S1.01
Hydrophobic TM3 L 170 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 170 3x54 G.H5 L 348 G.H5.20
Polar ICL2 Y 177 34x54 G.H5 D 350 G.H5.22
Van-der-waals ICL2 Y 177 34x54 G.H5 D 350 G.H5.22
Polar TM3 S 169 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 169 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 169 3x53 G.H5 C 351 G.H5.23
Polar TM6 K 276 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 276 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 276 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 174 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 V 252 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 252 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 G 277 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 259 5x72 G.H5 K 345 G.H5.17
Hydrophobic ICL2 R 180 34x57 G.HN A 27 G.HN.51
Van-der-waals ICL2 R 180 34x57 G.HN A 27 G.HN.51
Polar ICL2 T 175 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 175 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 175 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 Q 258 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 258 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM3 L 170 3x54 G.H5 L 353 G.H5.25
Polar C-term S 356 - G.H3 K 257 G.H3.16
Hydrophobic C-term S 356 - G.H3 K 257 G.H3.16
Van-der-waals C-term S 356 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 L 174 34x51 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 174 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 H 255 5x68 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 H 270 6x26 G.S6 Y 320 G.S6.02
Polar TM6 G 277 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 G 277 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 G 277 6x33 G.H5 L 353 G.H5.25
Ionic ICL2 R 180 34x57 G.hns1 E 30 G.hns1.01
Ionic H8 R 338 8x52 G.h4s6 D 315 G.h4s6.09
Polar H8 R 338 8x52 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 R 338 8x52 G.h4s6 D 315 G.h4s6.09
Polar ICL2 A 173 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 173 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 A 173 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 166 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 248 5x61 G.H5 L 353 G.H5.25
Ionic TM6 H 270 6x26 G.h4s6 E 318 G.h4s6.12