GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM5 | R | 236 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 236 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 236 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | S | 307 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | TM6 | K | 315 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | C | 323 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | N | 232 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | N | 232 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | A | 319 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | Q | 151 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 151 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | N | 153 | - | G.HN | I | 28 | G.HN.52 |
Hydrophobic | ICL2 | N | 153 | - | G.HN | I | 28 | G.HN.52 |
Van-der-waals | ICL2 | N | 153 | - | G.HN | I | 28 | G.HN.52 |
Van-der-waals | ICL2 | N | 153 | - | G.HN | K | 24 | G.HN.48 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 147 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | N | 153 | - | G.HN | G | 27 | G.HN.51 |
Van-der-waals | ICL2 | N | 153 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | TM6 | L | 311 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | L | 311 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | R | 154 | - | G.HN | K | 24 | G.HN.48 |
Van-der-waals | ICL2 | R | 154 | - | G.HN | K | 24 | G.HN.48 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | A | 319 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Polar | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Hydrophobic | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Van-der-waals | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Polar | TM6 | S | 312 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | Q | 304 | - | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | ICL3 | Q | 304 | - | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | ICL3 | Q | 304 | - | G.S6 | C | 321 | G.S6.03 |
Polar | ICL2 | R | 154 | - | G.HN | K | 21 | G.HN.45 |
Hydrophobic | ICL2 | R | 154 | - | G.HN | K | 21 | G.HN.45 |
Van-der-waals | ICL2 | R | 154 | - | G.HN | K | 21 | G.HN.45 |
Polar | ICL3 | Q | 304 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | Q | 304 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | Q | 304 | - | G.S6 | H | 322 | G.S6.04 |
Polar | ICL3 | S | 307 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL3 | Q | 304 | - | G.S6 | M | 323 | G.S6.05 |
Hydrophobic | ICL3 | Q | 304 | - | G.S6 | M | 323 | G.S6.05 |
Van-der-waals | ICL3 | Q | 304 | - | G.S6 | M | 323 | G.S6.05 |
Polar | TM6 | K | 315 | 6x29 | G.h4s6 | N | 316 | G.h4s6.10 |
Polar | TM6 | K | 318 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 318 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 318 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM6 | K | 315 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | TM3 | M | 146 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | Q | 304 | - | G.S5 | L | 269 | G.S5.06 |
Hydrophobic | ICL3 | L | 305 | - | G.H5 | V | 334 | G.H5.06 |
Hydrophobic | ICL3 | A | 308 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | A | 308 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | C-term | Y | 483 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | C-term | Y | 483 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | Y | 483 | - | G.H2 | K | 211 | G.H2.06 |
Polar | C-term | S | 484 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | C-term | S | 484 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | S | 484 | - | G.H2 | K | 211 | G.H2.06 |
Aromatic | C-term | Y | 517 | - | G.HN | R | 15 | G.HN.39 |
Hydrophobic | C-term | V | 540 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | V | 540 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | I | 485 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | I | 485 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | TM6 | T | 322 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | I | 326 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | P | 538 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | P | 538 | - | H.hbhc | T | 117 | H.hbhc.05 |
Polar | ICL2 | Q | 151 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Q | 151 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | Q | 151 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | P | 538 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | Q | 304 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL3 | Q | 304 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | G | 352 | G.H5.24 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM5 | I | 225 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | S | 312 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | S | 312 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | S | 312 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | I | 535 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | Y | 222 | 5x58 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 79 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM4 | S | 157 | 4x38 | G.HN | K | 24 | G.HN.48 |